Perspectives of Cytokine Treatment in Malignant Skin Tumors

Garbe, Claus

doi:10.1007/978-3-642-78771-3_27

Cited by 15 publications

(3 citation statements)

References 89 publications

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“…This may reflect autocrine stimulation of IL-2 by TNFSF9. The significance of this response is underlined by the effectiveness of interferons and IL-2 in the treatment of skin cancers that include metastatic melanomas (Garbe, 1995).…”

Section: Interleukins and Growth Factorsmentioning

confidence: 99%

A novel microarray to evaluate stress-related genes in skin: effect of ultraviolet light radiation

Pisarchik

Wortsman

Slominski

2004

Gene

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Section: Interleukins and Growth Factorsmentioning

confidence: 99%

A novel microarray to evaluate stress-related genes in skin: effect of ultraviolet light radiation

Pisarchik

Wortsman

Slominski

2004

Gene

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“…The first introduced Intralesional therapy was based on Bacille Calmette-Gué rin (BCG) [30], followed by the use of cytokines such as interferon (IFN) [31], and interleukin-2 (IL-2) [32,33]. Despite measurable autoimmune response, clinical response rates are disappointing.…”

Section: Intralesional Therapymentioning

confidence: 99%

Isolated limb perfusion for melanoma in-transit metastases: developments in recent years and the role of tumor necrosis factor alpha

Deroose

Eggermont

Geel

et al. 2011

Current Opinion in Oncology

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“…[2,5]. Ein Zulassung für das maligne Melanom besteht in Deutschland bis heute jedoch nicht, die Applikation erfolgt wie auch dessen Gabe zur Behandlung kolorektaler Karzinome oder Non-HodgkinLymphome im "off-label-use" [11].Zudem besteht zurzeit kein standardisiertes Behandlungsschema.…”

Section: Zusammenfassungunclassified

Komplette Remission kutaner Satelliten- und In-transit-Filiae nach intral�sionaler Interleukin-2-Applikation bei 2�Patienten mit malignem Melanom

et al. 2004

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Multiple cutaneous satellite and in-transit metastases of melanoma without involvement of lymph nodes or other organs are a challenge especially when they occur in elderly inoperable patients with multiple internal diseases. In this particular situation, intralesional application of interleukin-2 may represent an effective alternative to systemic chemo- or immunotherapy as it can be performed on an out-patient basis and has few side effects. We treated two elderly female patients with multiple cutaneous metastases of malignant melanoma with intra- and perilesional application of interleukin-2 (3 x 6-12 Mio IE) over 12 weeks and achieved a complete remission of these metastases. In follow-up biopsies, no viable tumor cells were found. Despite a slight burning at the injection side and a transient local inflammatory reaction, the therapy was well tolerated in both cases after premedication with paracetamol 500 mg orally and pretreatment of the injection site with a cream containing lidocaine and prilocaine. No systemic side effects were observed.

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Perspectives of Cytokine Treatment in Malignant Skin Tumors

Cited by 15 publications

References 89 publications

A novel microarray to evaluate stress-related genes in skin: effect of ultraviolet light radiation

A novel microarray to evaluate stress-related genes in skin: effect of ultraviolet light radiation

Isolated limb perfusion for melanoma in-transit metastases: developments in recent years and the role of tumor necrosis factor alpha

Komplette Remission kutaner Satelliten- und In-transit-Filiae nach intral�sionaler Interleukin-2-Applikation bei 2�Patienten mit malignem Melanom

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