Perspectives on the membrane fatty acid unsaturation/pacemaker hypotheses of metabolism and aging

Calhoon, Elisabeth A.; Ro, Jennifer; Williams, Joseph B.

doi:10.1016/j.chemphyslip.2015.08.008

Cited by 15 publications

(26 citation statements)

References 166 publications

(292 reference statements)

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“…An alternative, but mutually non-exclusive, explanation for dietand temperature-dependent variation in BMR is that the dominating MUFA oleic acid disproportionally affects lipid phase behaviour in membranes (Calhoon et al, 2015;Epand et al, 1991). In line with this hypothesis, the diet×temperature interaction for oleic acid follows the same direction as the interaction for BMR.…”

Section: Discussionmentioning

confidence: 90%

“…In addition, the FA composition of the diet can also affect metabolic rate through differences between FAs in their rate of oxidation (Leyton et al, 1987;Price et al, 2011), through FAspecific effects on cell membrane leakiness (Hulbert, 2008) and possibly through lipid phase behaviour (Calhoon et al, 2015;Epand et al, 1991). For instance, chickens feeding from diets rich in polyunsaturated fatty acids (PUFAs) tended to have higher resting metabolic rates (RMRs) than those feeding from SFA-enriched diets (Newman et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

“…An extended version of the oxidative stress theory of ageing is the 'membrane pacemaker theory of ageing' (Calhoon et al, 2015;Hulbert, 2005Hulbert, , 2008. This theory emphasizes that the FA composition of membranes influences their sensitivity to oxidative stress, with a higher degree of unsaturation increasing lipid peroxidation and consequently the rate of ageing (Hulbert, 2005).…”

Section: Introductionmentioning

confidence: 99%

“…In addition, an increased proportion of polyunsaturated fatty acids [PUFAs, especially docosahexaenoic acid (DHA)] in phospholipid bilayers is thought to result in leakier membranes, increasing metabolic rate through upregulated activity of membrane pumps to maintain electrochemical gradients (Hulbert, 2008). Hence, diet and ambient temperatures are likely to affect the links between metabolic rate and oxidative stress, both directly and indirectly, with potential consequences for longevity, although support for the membrane pacemaker theory is mixed (Calhoon et al, 2015;Price et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

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Diet and ambient temperature interact to shape plasma fatty acid composition, basal metabolic rate, and oxidative stress in great tits

Andersson

Nilsson

Isaksson

2018

Journal of Experimental Biology

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Diet and ambient temperature affect animal physiology, survival and reproductive success. However, knowledge of how these environmental factors interact to shape physiological processes and life-history traits of birds and other animals is largely lacking. By exposing adult great tits (Parus major) to two contrasting diets (saturated or unsaturated fatty acids; SFAs and UFAs, respectively) and ambient temperatures (3°C versus 20°C) that the birds encounter in nature, we investigated the effects of these two factors on several physiological parameters. Our results show that diet and ambient temperature interact to affect the composition of plasma fatty acids, basal metabolic rate (BMR) and oxidative stress, which are thought to affect the life-history and survival of individuals. Specifically, birds provided the SFA-rich diet had higher mass-specific BMR and oxidative stress (levels of lipid peroxidation) after exposure to low compared with high ambient temperature, whereas the opposite pattern was evident for birds with a UFA-rich diet. Surprisingly, birds on the SFA diet had higher relative levels of monounsaturated fatty acids compared with the UFA-fed birds at low ambient temperature, whereas the opposite, and expected, pattern was found at the high temperature. Although the present study focuses on the physiological implications of the diet×temperature interaction, our results might also be important for the leading theories of ageing, which currently do not take interactions between environmental factors into account. In addition, the present results are important for wildlife management, especially with regards to anthropogenic feeding of wild animals across variable and changing climatic conditions.

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Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Diet and ambient temperature interact to shape plasma fatty acid composition, basal metabolic rate, and oxidative stress in great tits

Andersson

Nilsson

Isaksson

2018

Journal of Experimental Biology

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“…Support for the membrane pacemaker hypothesis has been mixed (Calhoon et al, 2015). Primary support comes from cross-species correlations of membrane fatty acid composition, particularly in mammals and birds (Hulbert et al, 2002a,b;Turner et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

The membrane pacemaker hypothesis: novel tests during the ontogeny of endothermy

Price

Sirsat

et al. 2018

Journal of Experimental Biology

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The 'membrane pacemaker' hypothesis proposes a biochemical explanation for among-species variation in resting metabolism, based on the positive correlation between membrane docosahexaenoic acid (DHA) and metabolic rate. We tested this hypothesis using a novel model, altricial red-winged blackbird nestlings, predicting that the proportion of DHA in muscle and liver membranes should increase with the increasing metabolic rate of the nestling as it develops endothermy. We also used a dietary manipulation, supplementing the natural diet with fish oil (high DHA) or sunflower oil (high linoleic acid) to alter membrane composition and then assessed metabolic rate. In support of the membrane pacemaker hypothesis, DHA proportions increased in membranes from pectoralis muscle, muscle mitochondria and liver during post-hatch development. By contrast, elevated dietary DHA had no effect on resting metabolic rate, despite causing significant changes to membrane lipid composition. During cold challenges, higher metabolic rates were achieved by birds that had lower DHA and higher linoleic acid in membrane phospholipids. Given the mixed support for this hypothesis, we conclude that correlations between membrane DHA and metabolic rate are likely spurious, and should be attributed to a still-unidentified confounding variable.

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Hypoxia-induced remodelling of goldfish membranes

Farhat

Turenne

Choi

et al. 2019

Comparative Biochemistry and Physiology Part B: Biochemistry an

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Perspectives on the membrane fatty acid unsaturation/pacemaker hypotheses of metabolism and aging

Cited by 15 publications

References 166 publications

Diet and ambient temperature interact to shape plasma fatty acid composition, basal metabolic rate, and oxidative stress in great tits

Diet and ambient temperature interact to shape plasma fatty acid composition, basal metabolic rate, and oxidative stress in great tits

The membrane pacemaker hypothesis: novel tests during the ontogeny of endothermy

Hypoxia-induced remodelling of goldfish membranes

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