Despite the growing deployment of network representation throughout psychological sciences, the question of whether and how networks can systematically describe the effects of psychological interventions remains elusive. Towards this end, we capitalize on recent breakthrough in network control theory, the engineering study of networked interventions, to investigate a representative psychological attitude modification experiment. This study examined 30 healthy participants who answered 11 questions about their attitude toward eating meat. They then received 11 arguments to challenge their attitude on the questions, after which they were asked again the same set of questions. Using this data, we constructed networks that quantify the connections between the responses and tested: 1) if the observed psychological effect, in terms of sensitivity and specificity, relates to the regional network topology as described by control theory, 2) if the size of change in responses relates to whole-network topology that quantifies the “ease” of change as described by control theory, and 3) if responses after intervention could be predicted based on formal results from control theory. We found that 1) the interventions that had higher regional topological relevance (the so-called controllability scores) had stronger effect (r > 0.5), the intervention sensitivities were systematically lower for the interventions that were “easier to control” (r = -0.49), and that the model offered substantial prediction accuracy (r = 0.36). Finally, we compared results based on subjective as well as data-driven models and found that, across all tests, the results from the data-driven approach explained a larger size of effect. Taken together, our results suggest that psychological interventions can be studied using network control theory and that data-driven models provide a reliable medium.