Perturbation of 11-eicosenoate metabolism in female diabetic rats

Malaisse, Willy; Portois, Laurence; Sener, Abdullah; Carpentier, Yvon

doi:10.3892/ijmm.22.1.133

Cited by 3 publications

(4 citation statements)

References 6 publications

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“…However, the amount of other fatty acids is also important as it may indicate the direction of metabolic changes. The nervonic acid (NA; C 24:1), being a monounsaturated derivative of lignoceric acid, has been claimed to have beneficial effects on risk factors connected with obesity and diabetes [11,12]. As reported earlier, the content of this fatty acid was affected in peroxisomal disorders, diabetes, and undernourishment [13,14,15].…”

Section: Introductionmentioning

confidence: 99%

High-Fat Feeding in Time-Dependent Manner Affects Metabolic Routes Leading to Nervonic Acid Synthesis in NAFLD

Konstantynowicz-Nowicka

Berk

Chabowski

et al. 2019

IJMS

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Nonalcoholic fatty liver disease (NAFLD) is characterized by excessive lipid accumulation in the liver. The disturbances in the fatty acid composition of stored lipids are more important than the lipid species itself, which may influence the overall effect caused by these molecules. Thus, uncovering time-dependent changes in the fatty acid composition of accumulated lipid fractions after a high fat diet seems to be a new marker of NAFLD occurrence. The experiments were conducted on high fat fed Wistar rats. The blood and liver samples were collected at the end of each experimental week and used to assess the content of lipid fractions and their fatty acid composition by gas liquid chromatography. The expression of proteins from lipid metabolism pathways and of fatty acid exporting proteins were detected by Western blotting. In the same high fat feeding period, decreased de novo lipogenesis, increased β-oxidation and lipid efflux were demonstrated. The observed effects may be the first liver protective mechanisms against lipotoxicity. Nevertheless, such effects were still not sufficient to prevent the liver from proinflammatory lipid accumulation. Moreover, the changes in liver metabolic pathways caused the plasma nervonic acid concentration in sphingomyelin to decrease simultaneously with NAFLD development, which may be a steatosis occurrence prognostic marker.

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Section: Introductionmentioning

confidence: 99%

High-Fat Feeding in Time-Dependent Manner Affects Metabolic Routes Leading to Nervonic Acid Synthesis in NAFLD

Konstantynowicz-Nowicka

Berk

Chabowski

et al. 2019

IJMS

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“…It can be a marker of neurodegeneration, and its intake improves brain development [40,41]. Moreover, the latest publication confirms that NA also has beneficial effects on risk factors connected with adrenoleukodystrophy (ALD) [42], obesity and diabetes [43,44] or inflammatory bowel disease (IBD) [45], and understanding critical mechanisms should become a therapeutic approach [46]. It is noteworthy that the enzymes of n-3 fatty acid interconversion are shared with the analogous n-6 fatty acid biosynthetic pathway of conversion of LA to AA.…”

Section: Substrates For Na Synthesis Proved To Be Crucial In the Remy...mentioning

confidence: 98%

Nervonic Acid Synthesis Substrates as Essential Components in Profiled Lipid Supplementation for More Effective Central Nervous System Regeneration

Namiecinska,

Piatek,

Lewkowicz

2024

IJMS

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Central nervous system (CNS) damage leads to severe neurological dysfunction as a result of neuronal cell death and axonal degeneration. As, in the mature CNS, neurons have little ability to regenerate their axons and reconstruct neural loss, demyelination is one of the hallmarks of neurological disorders such as multiple sclerosis (MS). Unfortunately, remyelination, as a regenerative process, is often insufficient to prevent axonal loss and improve neurological deficits after demyelination. Currently, there are still no effective therapeutic tools to restore neurological function, but interestingly, emerging studies prove the beneficial effects of lipid supplementation in a wide variety of pathological processes in the human body. In the future, available lipids with a proven beneficial effect on CNS regeneration could be included in supportive therapy, but this topic still requires further studies. Based on our and others’ research, we review the role of exogenous lipids, pointing to substrates that are crucial in the remyelination process but are omitted in available studies, justifying the properly profiled supply of lipids in the human diet as a supportive therapy during CNS regeneration.

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“…C22:5x3 relative content (%) ND 1.15 ± 0.14 (2) 1.74 ± 0.05 (3) heparinized tubes. After centrifugation the plasma was removed and stored at -20°C for further determination of plasma glucose by the glucose oxidase method [23] using glucose analyzer (Beckman instruments) and plasma insulin by radioimmunoassay [24].…”

Section: Blood Collection and Preparation Of Pancreatic Isletsmentioning

confidence: 99%

“…Recent reports have drawn attention to the perturbation of the fatty acid content and pattern in epididymal or parametrial adipose tissue lipids, as well as plasma, liver, spleen, and brain phospholipids and triglycerides in animals models of both type 1 and type 2 diabetes [1][2][3][4][5][6][7]. To our knowledge, however, the fatty acid pattern of phospholipids and of triglycerides was so far never examined separately in each of these two lipid fractions in pancreatic islets of either normal or diabetic rats.…”

Section: Introductionmentioning

confidence: 99%

Fatty acid pattern of pancreatic islet lipids in Goto-Kakizaki rats

Giroix

Louchami

Carpentier

et al. 2009

Endocr

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Perturbations of fatty acid content and pattern were recently documented in epididymal and parametrial lipids, as well as plasma, liver, spleen, and brain phospholipids and triglycerides of Goto-Kakizaki rats (GK). This study extends such an investigation to pancreatic islets from both control and GK rats. Groups of 5,500-14,560 islets were obtained from either control or GK rats (n = 3 in each case) and examined for their lipid fatty acid content. In the islet triglycerides, the major difference between control and GK rats, i.e., a higher C18:2ω6 content in GK rats, was similar to that found in liver triglycerides. In the islet phospholipids, however, a number of differences between control and GK rats, concerning saturated, monodesaturated, and long-chain polyunsaturated ω3 and ω6 fatty acids, were often not similar to those found in liver phospholipids. The present study reveals a number of anomalies in the fatty acid pattern of islet phospholipids in GK rats, often differing from those encountered in liver phospholipids. Such a tissue specificity was borne out by the finding that, even in control animals, the situation found in islet phospholipids differed from that recorded in liver phospholipids.

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Perturbation of 11-eicosenoate metabolism in female diabetic rats

Cited by 3 publications

References 6 publications

High-Fat Feeding in Time-Dependent Manner Affects Metabolic Routes Leading to Nervonic Acid Synthesis in NAFLD

High-Fat Feeding in Time-Dependent Manner Affects Metabolic Routes Leading to Nervonic Acid Synthesis in NAFLD

Nervonic Acid Synthesis Substrates as Essential Components in Profiled Lipid Supplementation for More Effective Central Nervous System Regeneration

Fatty acid pattern of pancreatic islet lipids in Goto-Kakizaki rats

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