Perturbations in different forms of cost/benefit decision making induced by repeated amphetamine exposure

Floresco, Stan; Whelan, Jennifer M.

doi:10.1007/s00213-009-1529-0

Cited by 53 publications

(40 citation statements)

References 46 publications

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“…Previous studies have shown that a history of chronic drug exposure alters discounting of delayed rewards, resulting in impulsivity (23). Similar maladaptive discounting processes resulting from drug exposure may affect choices associated with other costs, such as risk (15). Indeed, the results of Experiment 1 demonstrate that risk preference after a history of adolescent alcohol exposure is associated with altered dopamine signaling to risk.…”

Section: Discussionmentioning

confidence: 79%

“…Phasic increases in dopamine transmission are evoked by rewarding outcomes and associated cues (10,11), both of which have been shown to scale with the magnitude and the probability of reward (12,13). Indeed, it has been suggested that midbrain dopamine neurons specifically encode risk along with reward value (14), and models of probabilistic choice have implicated the ventral striatum in mediating risk-associated decisions (6,7,(15)(16). Similarly, phasic dopamine signaling within the ventral striatum has been previously linked to value-based decision making (13,17).…”

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confidence: 99%

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Risk preference following adolescent alcohol use is associated with corrupted encoding of costs but not rewards by mesolimbic dopamine

Nasrallah¹,

Clark

Collins³

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

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Several emerging theories of addiction have described how abused substances exploit vulnerabilities in decision-making processes. These vulnerabilities have been proposed to result from pharmacologically corrupted neural mechanisms of normal brain valuation systems. High alcohol intake in rats during adolescence has been shown to increase risk preference, leading to suboptimal performance on a decision-making task when tested in adulthood. Understanding how alcohol use corrupts decision making in this way has significant clinical implications. However, the underlying mechanism by which alcohol use increases risk preference remains unclear. To address this central issue, we assessed dopamine neurotransmission with fast-scan cyclic voltammetry during reward valuation and risk-based decision making in rats with and without a history of adolescent alcohol intake. We specifically targeted the mesolimbic dopamine system, the site of action for virtually all abused substances. This system, which continuously develops during the adolescent period, is central to both reward processing and risk-based decision making. We report that a history of adolescent alcohol use alters dopamine signaling to risk but not to reward. Thus, a corruption of cost encoding suggests that adolescent alcohol use leads to long-term changes in decision making by altering the valuation of risk.

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Section: Discussionmentioning

confidence: 79%

mentioning

confidence: 99%

Risk preference following adolescent alcohol use is associated with corrupted encoding of costs but not rewards by mesolimbic dopamine

Nasrallah¹,

Clark

Collins³

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

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“…The primary task used in these studies has been described previously (Floresco and Whelan, 2009;GhodsSharifi et al, 2009;Floresco, 2009, 2010;, and was originally modified from that described by Cardinal and Howes (2005) (Fig. 1).…”

Section: Methodsmentioning

confidence: 99%

Dissociable Contributions by Prefrontal D1 and D2 Receptors to Risk-Based Decision Making

Onge

Abhari²,

Floresco³

2011

Journal of Neuroscience

173

152

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Choices between certain and uncertain rewards of different magnitudes have been proposed to be mediated by both the frontal lobes and the mesocorticolimbic dopamine (DA) system. In rats, systemic manipulations of DA activity or inactivation of the medial prefrontal cortex (PFC) disrupt decision making about risks and rewards. However, it is unclear how PFC DA transmission contributes to these processes. We addressed this issue by examining the effects of pharmacological manipulations of D 1 and D 2 receptors in the medial (prelimbic) PFC on choice between small, certain and large, yet probabilistic rewards. Rats were trained on a probabilistic discounting task where one lever delivered one pellet with 100% probability, and the other delivered four pellets, but the probability of receiving reward decreased across blocks of trials (100, 50, 25, 12.5%). D 1 blockade (SCH23390) in the medial PFC decreased preference for the large/risky option. In contrast, D 2 blockade (eticlopride) reduced probabilistic discounting and increased risky choice. The D 1 agonist SKF81297 caused a slight, nonsignificant increase in preference for the large/risky lever. However, D 2 receptor stimulation (quinpirole) induced a true impairment in decision making, flattening the discounting curve and biasing choice away from or toward the risky option when it was more or less advantageous, respectively. These findings suggest that PFC D 1 and D 2 receptors make dissociable, yet complementary, contributions to risk/reward judgments. By striking a fine balance between D 1 /D 2 receptor activity, DA may help refine these judgments, promoting either exploitation of current favorable circumstances or exploration of more profitable ones when conditions change.

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“…Risk-discounting task The primary task used in these studies has been described previously (Floresco & Whelan, 2009;Ghods-Sharifi et al, 2009;St. Onge, Chiu, & Floresco, 2010;, which was originally modified from that described by Cardinal and Howes (2005) (see Fig.…”

Section: Decision-making Tasksmentioning

confidence: 99%

Contributions of the nucleus accumbens and its subregions to different aspects of risk-based decision making

Stopper

Floresco

2010

Cogn Affect Behav Neurosci

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142

147

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The nucleus accumbens (NAc) has been implicated in mediating different forms of decision making in humans and animals. In the present study, we observed that inactivation of the rat NAc, via infusion of GABA agonists, reduced preference for a large/risky option and increased response latencies on a probabilistic discounting task. Discrete inactivations of the NAc shell and core revealed further differences between these regions in mediating choice and response latencies, respectively. The effect on choice was attributable to reduced win-stay performance (i.e., choosing risky after a being rewarded for a risky choice on a preceding trial). Moreover, NAc inactivation altered choice only when the large/risky option had greater long-term value, in terms of the amount of food that could be obtained over multiple trials relative to the small/certain option. Inactivation of the NAc or the shell subregion also slightly reduced preference for larger rewards on a reward magnitude discrimination. Thus, the NAc seems to play a small role in biasing choice toward larger rewards, but its contribution to behavior is amplified when delivery of these rewards is uncertain, helping to direct response selection toward more favorable outcomes.

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Perturbations in different forms of cost/benefit decision making induced by repeated amphetamine exposure

Cited by 53 publications

References 46 publications

Risk preference following adolescent alcohol use is associated with corrupted encoding of costs but not rewards by mesolimbic dopamine

Risk preference following adolescent alcohol use is associated with corrupted encoding of costs but not rewards by mesolimbic dopamine

Dissociable Contributions by Prefrontal D1 and D2 Receptors to Risk-Based Decision Making

Contributions of the nucleus accumbens and its subregions to different aspects of risk-based decision making

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