Perturbations in gut microbiota composition in patients with polycystic ovary syndrome: a systematic review and meta-analysis

Li, Pan; Shuai, Ping; Shen, Sj; Wang, Cong-Yi; Park, Sun; Zhang, Renfang; Lan, Shanwei; Lan, Zixin; Jayawardana, Thisun; Yang, Yanchen; Zhao, Jing; Yu-ping, Liu; Chen, Xia; El‐Omar, Emad; Wan, Zhengwei

doi:10.1186/s12916-023-02975-8

Cited by 23 publications

(8 citation statements)

References 81 publications

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“…30 A recent study demonstrated that several SCFAproducing bacteria decreased significantly in patients with PCOS, including Butyricimonas, Blautia, Coprococcus, and F. prausnitzii. 31 These bacteria are regarded as SCFA producers and have beneficial effects on hosts. F. prausnitzii exhibits anti-inflammatory activity and maintains mucosal immune homeostasis.…”

Section: The Content Of Scfa Affects Insulin Resistance Occurrencementioning

confidence: 99%

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Role of the gut microbiota and innate immunity in polycystic ovary syndrome: Current updates and future prospects

Zhou,

Yu,

et al. 2024

J Cellular Molecular Medi

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Polycystic ovary syndrome (PCOS) is one of the modern intractable reproductive diseases. The female irregular menstruation, infertility, obesity, and so forth caused by PCOS have become a hot issue affecting family harmony and social development. The aetiology of PCOS is complex. In recent years, many scholars have found that its pathogenesis was related to the imbalance of gut microbiota. Gut microbiota can form two‐way communication with the brain through the ‘gut‐brain axis’ and affect the host's metabolism. Current research has confirmed that the gut microbiota can interfere with glucose and lipid metabolism, insulin sensitivity, hormone secretion and follicular development in women by altering intestinal mucosal permeability and secreting metabolites. In addition, the diversity and composition of gut microbiota of PCOS patients changed, which may affect the metabolic function of the gut microbiota and the ability to produce metabolites, and may also directly or indirectly affect the endocrine function. This study reviewed recent research advances about the role of gut microbiota in PCOS. In order to provide basis for prevention and treatment of PCOS based on gut microbiota.

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Section: The Content Of Scfa Affects Insulin Resistance Occurrencementioning

confidence: 99%

“…prausnitzii . 31 These bacteria are regarded as SCFA producers and have beneficial effects on hosts. F .…”

Section: The Role Of Gut Microbiota In the Pathogenesis Of ...mentioning

confidence: 99%

Role of the gut microbiota and innate immunity in polycystic ovary syndrome: Current updates and future prospects

Zhou,

Yu,

et al. 2024

J Cellular Molecular Medi

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“…The contribution of the microbiota in the development and course of various gynecological diseases was studied by a number of scientists [14,[48][49][50]. Nowadays a great attention is to the meaning of vaginal and gut microbiota in PCOS course [51,52]. Gut microbiota influences of the development and course of PCOS and other diseases that can be associated with coronary pathology, obesity, T2DM.…”

Section: г і н е к о л о г і яmentioning

confidence: 99%

“…The researches showed that there is gut dysbiosis in PCOS patients, "which might be characterized by the reduction of short-chain fatty acid-producing and bile-acidmetabolizing bacteria, suggests a shift in balance to favor pro-inflammatory rather than anti-inflammatory bacteria" [51]. P. J. Torres et al found that low α diversity by PCOS which was negatively correlated with hyperandrogenism, total testosterone and hirsutism [61].…”

Section: г і н е к о л о г і яmentioning

confidence: 99%

The modern pathogenetic challenges of polycystic ovary syndrome

Pakharenko,

Zhylka,

Shcherbinska

et al. 2024

RHW

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Polycystic ovary syndrome (PCOS) is one of the neuroendocrine syndromes in women of reproductive age. In the pathogenesis of its development a great importance is paid to the hormonal disbalance, metabolic changes, overweight and obesity, diabetes mellitus, insulin resistance, genetic factors, etc. Very often, PCOS is accompanied by infertility, cardiovascular risks, diabetes mellitus.The article is devoted to a review of modern scientific literature about the last researches devoted to the mechanisms of metabolic disorders which are connected with insulin resistance, overweight and obesity, also, with psychological disturbance and stress. The article describes the specific of psychological conditions in PCOS patients. On the basis of the analyzed scientific publications the connection between hormonal disbalance, psychological disorders, overweight, obesity and lipidogram parameters is presented.Also, the researches about gut and vaginal microbiota are described in this paper. The last studies demonstrate the significant changes of human microbiome in the development and course of polycystic ovary syndrome. The article presents the concepts of the difference in the composition of the gut and vagina microbiota in women with this neuroendocrine syndrome.The pathogenetic mechanisms of the role of the microbiota in the processes of PCOS pathogenesis, namely, the regulation of the immune response and inflammation processes in this pathology, are described. It has been shown that in women with PCOS there are differences in the microflora composition of the intestines, manifested by a decreased concentration of Lactobacillus and the presence of a variety of other microorganisms compared to the healthy women.Thus, the main pathogenetic links of PCOS development are closely connected with each other. That is why multimodal approaches for study of PCOS and for management of the patients with PCOS are extremely important.

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“…Thus, alpha diversity measures the diversity of a particular population within the sample, while beta diversity measures are estimates of similarity between samples [18,19]. A systematic review in adult women with PCOS has demonstrated a significant alteration of the gut microbiota [20].…”

Section: Introductionmentioning

confidence: 99%

The Role of the Gut Microbiome in Youth with Polycystic Ovary Syndrome: A Systematic Review

Tsinopoulou,

Kotanidou,

Athanasiadis

et al. 2023

Children

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Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects women of reproductive age and female adolescents. The diagnosis of PCOS is difficult during puberty due to overlapping of the criteria with normal variations of menstruation during this age period. There are insufficient data on the gut microbiome and PCOS and potential mechanisms linking the two. The present systematic review aimed to detect dysbiosis patterns in youth with PCOS, compared with healthy controls. Methods: One hundred seventy-eight studies were identified by a databases search and sixty-eight by a full-text assessment for eligibility; four were included in the systematic review and underwent quality control. Results: The results of the study were controversial in accordance to findings from the literature. A change in gut microbiome α diversity was found in PCOS adolescents, with no significant alterations in β diversity. Almost all studies found Firmicutes, Bacteroidetes, and Actinobacteria in abundance in both groups, with changes in family composition and fluctuations at the phylum level. A statistically significant association between these changes and clinical or biochemical features of the syndrome was described. Conclusions: This systematic review confirmed gut microbiota dysbiosis in youth with PCOS. However, further data are needed to clarify these changes and to build a strategy to prevent the syndrome.

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Perturbations in gut microbiota composition in patients with polycystic ovary syndrome: a systematic review and meta-analysis

Cited by 23 publications

References 81 publications

Role of the gut microbiota and innate immunity in polycystic ovary syndrome: Current updates and future prospects

Role of the gut microbiota and innate immunity in polycystic ovary syndrome: Current updates and future prospects

The modern pathogenetic challenges of polycystic ovary syndrome

The Role of the Gut Microbiome in Youth with Polycystic Ovary Syndrome: A Systematic Review

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