Pertussis in Afghanistan, 2007–2008

Kakar, Rishtya; Mojadidi, Mohammad K.; Jawad, Mofleh

doi:10.3201/eid1503.080982

Cited by 7 publications

(1 citation statement)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When the relative coverage rates of pertussis among male and female children were considered, there was a slight increase of the rate among males (81%) compared with females (75.7%), but this result was not statistically significant (Table 1). It is reminiscent of the findings of Kakar et al [28] in Afghanistan, where the pertussis vaccine coverage rate among male infants and children (75%) was, however, considerably higher than that for females (50%). These results reflect continuing sex discrimination against females in 3 rd world countries, particularly in Islamic countries.…”

Section: Discussionmentioning

confidence: 52%

Bordetella pertussis: Vaccine Coverage and Immune Status among Children Under Five Years Old in Sana’a City, Yemen

Al-Shamahy

Al-Wafi

2019

IJTDH

View full text Add to dashboard Cite

Aims:This study was made to evaluate the immune response to pertussis among children under five years old by measuring the level of circulating Immunoglobulin G (IgG) antibodies against pertussis toxin (IgG-PT) after immunization with the primary series of DPT (DPT1-3) and then determining the coverage rates of universal childhood vaccines. Study Design: Cross-sectional laboratory study. Place and Duration of Study: Methodology: A total of 345 children were randomly selected and investigated for universal childhood vaccination coverage rates; of these, 273 children who had received 3 full doses of DPT were studied for their pertussis immunological status. Blood samples were collected from the latter group and then tested for levels of IgG-PT by ELISA method. For assessment IgG-PT levels more than 24 units/ml were considered protected against pertussis. Data were analyzed according to Al-Shamahy and Al-Wafi; IJTDH, 35(3): 1-7, 2019; Article no.IJTDH.8143 2 gender and age groups. Results: The coverage rate of pertussis vaccine was 79.1%; only 71.4% of vaccinated children responded to the vaccine with mean level of 33 U/ml. A statistically significant difference was observed with respect to sero-protective IgG-PT between males and females (63.8% and 84.8% respectively, with χ 2 =15, p=0.0001). Also, a statistically significant difference was observed with respect to sero-protective IgG-PT in different age groups, with older children (>48 months) having a higher rate of antibodies than younger (13-24 months) (90% and 59.1% respectively, with χ 2 =3.87, p=.04). Original Research Article Conclusion:We conclude that a considerable proportion of vaccinated children with a normal immune status were not serologically immune to pertussis. They remain to be reconsidered for either revaccination or booster doses due to lack of or inadequate response. Also, the rates of vaccine coverage for the main universal childhood vaccines are low.

show abstract

Section: Discussionmentioning

confidence: 52%