Perubahan Berat Organ Hati, Ginjal, Limfa, Otak, Lambung, Testis, Jantung dan Paru-paru Mencit yang Diberi Ekstrak Batang Sipatah-patah (Cissus quadrangula Salisb.)

Ceriana, Ria; Fitri, Saslina; Sari, Widya

doi:10.33143/jhtm.v4i1.201

Cited by 3 publications

(3 citation statements)

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“…A comparable investigation utilizing sipatah-patah stem extract containing flavonoids found no significant variation in the liver weight of mice [21]. Another study utilizing nano herbs from Phaleria macrocarpa in rats with doses up to 1608.1 mg/kg BW/day found no significant variation in the hepatic weight of mice [16].…”

Section: Discussionmentioning

confidence: 95%

“…This is conceivable because the liver is a critical organ in the body's homeostatic processes, metabolism, and toxin detoxification, as well as its involvement in regulating endogenous and external xenobiotics [24]. The liver contains Kupferr cells, which phagocytize poisons and other foreign substances/objects [21,25]. Subchronic toxicity tests on rats using flavonoids in Parkinson's therapy evaluating body weight, haematology, clinical biochemistry, and histopathology found that using flavonoids from Safflower at doses of 100, 300, and 500 mg/kgBW/day did not create toxic consequences [26].…”

Section: Discussionmentioning

confidence: 99%

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Hepatotoxicity Oral Administration of Flavonoids Rich Extract from Phaleria Macrocarpha in Mice

Siskanita Fitriana,

Sri Andarini,

Sutrisno

et al. 2023

a-jhr

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Introduction : Herbal medications are increasingly being used to treat a wide range of illnesses. Phaleria macrocarpa, often known as the crown of the gods, is a plant rich in flavonoids that is frequently used in herbal therapy. The goal of this study was to see what effect a flavonoid-rich extract from phaleria macrocarpa has on the livers of mice. Material and Methode : This study used adult female mice aged 6-8 weeks and weighing 20-30 gr as experimental animals, which were divided into four groups: the control group was given distilled water, group 2 was given a flavonoid dose of 500 mg/kg/day, group 3 was given a flavonoid dose of 1000 mg/kg/day, and group 4 was given a flavonoid dose of 2000 mg/kg/day. The flavonoid-rich extract of Phaleria macrocarpa was administered for 28 days. On the 29th day, the mice were necropsied, followed by surgery and examination of the mice's livers. Result : The flavonoid-rich extract of phaleria macrocarpa at a dose of 500 mg/kg body weight/day resulted in no changes in the weight or histological structure of the liver (p>0.05). Hydropic degeneration and necrosis were observed in the group administered the flavonoid-rich extract of phaleria macrocarpa at doses of 1000 and 2000 mg/kg body weight/day. Conclusion : The administration of a flavonoid-rich extract from Phaleria macrocarpa at a level of 500 mg/kg body weight/day caused no harm in the liver of mice. The use of more than 500 mg/kg body weight/day over an extended period of time has hazardous effects and is not recommended.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Hepatotoxicity Oral Administration of Flavonoids Rich Extract from Phaleria Macrocarpha in Mice

Siskanita Fitriana,

Sri Andarini,

Sutrisno

et al. 2023

a-jhr

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“…In the P3 group, the average dose of allopurinol 30mg/kg BW was 1.16 gr, a difference of 0.18 gr from the control group (Table 3). The liver is an important organ in the detoxification process or defense against various foreign substances, bacterial invasion, and toxins, so the liver weight can change due to substance intake (Ceriana et al, 2018). Liver weight can decrease may be due to exposure to allopurinol, which can liver cells undergo necrosis.…”

Section: Resultsmentioning

confidence: 99%

Allopurinol Induction on Histopathological Structure of the Liver in Male Mice (Mus musculus)

et al. 2022

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Allopurinol is used to reduce total uric acid levels in the body into oxypurinol which can inhibit xanthine oxidase. Allopurinol inhibits the precursors of uric acid formation, xanthine, and hypoxanthine. However, consumption of the drugs can cause side effects on the liver. The aim of the research was to determine the effect of allopurinol induction on the liver histopathology of male mice (Mus musculus) DDY strain. The method used in this research was an experimental design used post-test only that was divided into 4 groups of 4 mice per group. The control group (P0) was given 0.5% Na-CMC, and groups I, II, and III (P1, P2, and P3) were induced by allopurinol at 10 mg/kg BW, 20 mg/kg BW, and 30 mg/kg BW for 14 days. Allopurinol induction was performed by oral gavage. The results of the research showed that treatment with allopurinol caused changes in the mice’s body weight, liver index, liver morphology, and histological structure of the liver tissue, including necrosis, steatosis, leukocyte infiltration, binuclear hepatocytes, hepatocyte swelling, congestion, sinusoid dilatation, and hemorrhage. The level of liver damage increased in line with the dose used. This research indicated that the higher the allopurinol level, the higher the level of alteration in the liver section structure. Long-term use of allopurinol can cause damage to the structure of mice liver (liver toxicity).

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High Dose Sesbania Grandiflora Extract Alters Rat Kidney Electrolytes based on Insights from Indonesia

Hidayat,

Rohmah

2024

acopen

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This study investigates the acute toxicity of white turi flower extract (Sesbania grandiflora) on kidney electrolyte levels in rats (Rattus norvegicus). Conducted at Muhammadiyah University of Sidoarjo, male Wistar rats were divided into control and treatment groups, receiving 10,000, 15,000, and 20,000 mg/kgBW doses. Symptoms of toxicity included lethargy and hair loss, but no deaths occurred. Despite normal macroscopic kidney observations, sodium and potassium levels significantly increased with higher doses (p=0.000). These findings suggest that high doses of white turi flower extract can affect kidney electrolytes, indicating potential toxicity. Further research is needed to assess long-term safety for medicinal use. Highlights: 1. High doses increase sodium and potassium in rat kidneys.2. Symptoms: lethargy, hair loss, no fatalities.3. Requires further research for long-term safety. Keywords: Sesbania grandiflora, acute toxicity, kidney electrolytes, sodium, potassium

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Perubahan Berat Organ Hati, Ginjal, Limfa, Otak, Lambung, Testis, Jantung dan Paru-paru Mencit yang Diberi Ekstrak Batang Sipatah-patah (Cissus quadrangula Salisb.)

Cited by 3 publications

References 0 publications

Hepatotoxicity Oral Administration of Flavonoids Rich Extract from Phaleria Macrocarpha in Mice

Hepatotoxicity Oral Administration of Flavonoids Rich Extract from Phaleria Macrocarpha in Mice

Allopurinol Induction on Histopathological Structure of the Liver in Male Mice (Mus musculus)

High Dose Sesbania Grandiflora Extract Alters Rat Kidney Electrolytes based on Insights from Indonesia

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