Pestalachlorides A–C, antifungal metabolites from the plant endophytic fungus Pestalotiopsis adusta

Li, Erwei; Jiang, Lihua; Guo, Liangdong; Zhang, Hua; Che, Yongsheng

doi:10.1016/j.bmc.2008.07.075

Cited by 224 publications

(124 citation statements)

References 22 publications

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“…More than 200 species of endophytic fungi have been isolated and identified from mangrove plants and several reports on the isolation of antibiotic compounds from endophytic fungi have been reported. To mention a few griseofulvin, [7], chaetomugilin A and D [8], cytosporone B and C [9], 3-O-methylalaternin and altersolanol A [10], phomoenamide [11], phomodione [12], ambuic acid [13], isopestacin [14], munumbicin A, B, C, and D [15], pestalachlorides A and B, [16], brefeldin A [17], coronamycin, [18], pumilacidin [19], cytochalasin D [20], polyketide citrinin [21,22], fumigaclavine C, fumitremorgin C, physcion [23], and several others.…”

Section: Introductionmentioning

confidence: 99%

Isolation and Characterization of Antibacterial Compound from a Mangrove-Endophytic Fungus, Penicillium chrysogenum MTCC 5108

et al. 2012

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Microorganisms, especially endophytic fungi that reside in the tissue of living mangrove plants, seem to play a major role in meeting the general demand for new biologically active substances. During the course of screening for biologically active secondary metabolites from marine microorganisms, an antibiotic compound containing an indole and a diketopiperazine moiety was isolated from the culture medium of Penicillium chrysogenum, (MTCC 5108), an endophytic fungus on the mangrove plant Porteresia coarctata (Roxb.). The cell free culture medium of P. chrysogenum showed significant activity against Vibrio cholerae, (MCM B-322), a pathogen causing cholera in humans. Bioassay guided chemical characterization of the crude extract led to the isolation of a secondary metabolite possessing a molecular formula C 19 H 21 O 2 N 3 . Its antibacterial activity was comparable with standard antibiotic, streptomycin. This compound (1) was found to be (3,1 0 -didehydro-3[2 00 (3 000 ,3 000 -dimethyl-prop-2-enyl)-3 00 -indolylmethylene]-6-methyl pipera-zine-2,5-dione) on the basis of mass spectrometry, infrared spectroscopy and one and two-dimensional nuclear magnetic resonance analysis.

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Section: Introductionmentioning

confidence: 99%

Isolation and Characterization of Antibacterial Compound from a Mangrove-Endophytic Fungus, Penicillium chrysogenum MTCC 5108

et al. 2012

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“…Up to now, about nine isopentenyl dibenzo[b,e] oxepinones had been reported from fungi in Nature, including arugosins A-D from Aspergillus rugulosus [1,2] and A. variecolor [3], arugosin G from Emericella nidulans var. acristata [4], pestalachloride B from Pestalotiopsis adusta [5], cephalanones D-E from Graphiopsis chlorocephala [6], and 1,6,10-trihydroxy-8-methyl-2-(3-methyl-2-butenyl)-dibenz[b,e]oxepin-11(6H)-one (CAS: 160585-91-1, 5) from Penicilium sp. [7].…”

Section: Introductionmentioning

confidence: 99%

Three Pairs of New Isopentenyl Dibenzo[b,e]oxepinone Enantiomers from Talaromyces flavus, a Wetland Soil-Derived Fungus

et al. 2016

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Three pairs of new isopentenyl dibenzo[b,e]oxepinone enantiomers, (+)-(5S, and a new isopentenyl dibenzo [b,e]oxepinone, arugosin N (4), were isolated from a wetland soil-derived fungus Talaromyces flavus, along with two known biosyntheticallyrelated compounds 5 and 6. Among them, arugosin N (4) and 1,6,10-trihydroxy-8-methyl-2-(3-methyl-2-butenyl)-dibenz[b,e]oxepin-11(6H)-one (CAS: 160585-91-1, 5) were obtained as the tautomeric mixtures. The structures of isolated compounds were determined by detailed spectroscopic analysis. In addition, the absolute configurations of these three pairs of new enantiomers were determined by quantum chemical ECD calculations.

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“…Kapang endofit diketahui dapat melakukan mekanisme pertahanan diri dari serangan patogen dengan memproduksi senyawa yang bersifat antimikroba (Yu et al, 2010). Isolat kapang endofit yang memiliki aktivitas antimikroba menandakan bahwa kapang endofit tersebut juga memungkinkan memiliki potensi yang bagus untuk diuji kembali aktivitas antimikrobanya terhadap jenis mikroba patogen lainnya (Li, Jiang, Guo, Zhang, & Che, 2008). Senyawa bioaktif dari metabolit sekunder kapang endofit memiliki kemampuan sebagai agen biokontrol yang dapat dimanfaatkan untuk industri medis, pertanian dan lain-lain (Sudha, Govindaraj, Baskar, & Al-dhabi, 2016).…”

Section: Aktivitas Antimikroba Isolat Kapang Endofitunclassified

Isolasi dan Uji Aktivitas Antimikroba Kapang Endofit dari Kayu Ulin (Eusideroxylon zwageri Teijsm & Binn.) (Isolation and Antimicrobial Activity of Endophytic Fungi from Ulin (Eusideroxylon zwageri Teijsm & Binn.))

Khairiah¹,

Nintasari²

2017

J. Ris. Ind. Has. Hutan

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ABSTRAKKapang endofit berpotensi sebagai antibakteri, antifungi, antioksidan, antikanker dan antivirus. Salah satu sumber isolat kapang endofit adalah kayu ulin (Eusideroxylon zwageri Teijsm & Binn.) yang menghasilkan senyawa antimikroba yang sama dengan kayu ulin itu sendiri. Tujuan penelitian ini adalah mengisolasi kapang endofit dari ranting kayu ulin, menguji aktivitas antimikroba dan antioksidannya. Isolat yang didapatkan difermentasi pada media PDB (Potato Dextrose Broth), diuji aktivitas antimikroba pada tiga jenis mikroba uji (Eschericiacoli, Pseudomonas aeruginosa, Enterococcus aerogenes) dan diuji antioksidannya. Pada penelitian ini didapatkan dua isolat kapang endofit (putih/PT dan hitam kehijauan/HT). Kapang endofit HT memiliki zona hambat tertinggi terhadap bakteri E. coli dan P. aeruginosa masing-masing sebesar 12 mm, sedangkan pada bakteri E. aerogenes hanya memiliki zona hambat 11,5 mm. Kapang endofit PT hanya menghambat pertumbuhan bakteri E.coli saja dengan zona hambat 11,5 mm, sedangkan aktivitas antioksidan tertinggi terdapat pada kapang endofit HT sebesar 47,47 %.

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Pestalachlorides A–C, antifungal metabolites from the plant endophytic fungus Pestalotiopsis adusta

Cited by 224 publications

References 22 publications

Isolation and Characterization of Antibacterial Compound from a Mangrove-Endophytic Fungus, Penicillium chrysogenum MTCC 5108

Isolation and Characterization of Antibacterial Compound from a Mangrove-Endophytic Fungus, Penicillium chrysogenum MTCC 5108

Three Pairs of New Isopentenyl Dibenzo[b,e]oxepinone Enantiomers from Talaromyces flavus, a Wetland Soil-Derived Fungus

Isolasi dan Uji Aktivitas Antimikroba Kapang Endofit dari Kayu Ulin (Eusideroxylon zwageri Teijsm & Binn.) (Isolation and Antimicrobial Activity of Endophytic Fungi from Ulin (Eusideroxylon zwageri Teijsm & Binn.))

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