Pesticide mixture toxicity assessment through in situ and laboratory approaches using embryo-larval stages of the pacific oyster (Magallana gigas)

Kuchovská, Eliška; Gonzalez, Patrice; Bláhová, Lucie; Barré, Mathilde; Gouffier, Corentin; Cachot, Jérôme; Romero-Ramirez, Alicia; Bláha, Luděk; Morin, Bénédicte

doi:10.1016/j.marenvres.2021.105390

Cited by 6 publications

(1 citation statement)

References 61 publications

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“…However, two great challenges are emerging: (i) the study of complex mixtures to better fit environmentally relevant conditions and (ii) the integration of intergenerational and evolutionary perspectives . If a growing body of literature investigates binary and ternary mixtures, the issue of complex cocktails remains less addressed, notably in molluscs where the few existing studies do not allow a satisfactory risk assessment. − On the other hand, intergenerational ecotoxicological studies mostly focus on shorter generation-time species, i.e., zebrafish or daphnia, which are less ecologically relevant. Considering longer generation-time species like molluscs, the available studies usually investigated the parental effects of exposure during parental gametogenesis, , and to our knowledge, the multigenerational effects of early exposures in the Pacific oyster have only been addressed once, in the case of a microbiota study …”

Section: Introductionmentioning

confidence: 99%

Ancestors’ Gift: Parental Early Exposure to the Environmentally Realistic Pesticide Mixture Drives Offspring Phenotype in a Larger Extent Than Direct Exposure in the Pacific Oyster, Crassostrea gigas

Sol Dourdin,

Guyomard,

Rabiller

et al. 2024

Environ. Sci. Technol.

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Marine organisms are threatened by the presence of pesticides in coastal waters. Among them, the Pacific oyster is one of the most studied invertebrates in marine ecotoxicology where numerous studies highlighted the multiscale impacts of pesticides. In the past few years, a growing body of literature has reported the epigenetic outcomes of xenobiotics. Because DNA methylation is an epigenetic mark implicated in organism development and is meiotically heritable, it raises the question of the multigenerational implications of xenobioticinduced epigenetic alterations. Therefore, we performed a multigenerational exposure to an environmentally relevant mixture of 18 pesticides (nominal sum concentration: 2.85 μg•L −1 ) during embryo−larval stages (0−48 hpf) of a second generation (F1) for which parents where already exposed or not in F0. Gene expression, DNA methylation, and physiological end points were assessed throughout the life cycle of individuals. Overall, the multigenerational effect has a greater influence on the phenotype than the exposure itself. Thus, multigenerational phenotypic effects were observed: individuals descending from exposed parents exhibited lower epinephrine-induced metamorphosis and field survival rates. At the molecular level, RNA-seq and Methyl-seq data analyses performed in gastrula embryos and metamorphosis-competent pediveliger (MCP) larvae revealed a clear F0 treatment-dependent discrimination. Some genes implicated into shell secretion and immunity exhibited F1:F0 treatment interaction patterns (e.g., Calm and Myd88). Those results suggest that low chronic environmental pesticide contamination can alter organisms beyond the individual scale level and have long-term adaptive implications.

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Section: Introductionmentioning

confidence: 99%

Ancestors’ Gift: Parental Early Exposure to the Environmentally Realistic Pesticide Mixture Drives Offspring Phenotype in a Larger Extent Than Direct Exposure in the Pacific Oyster, Crassostrea gigas

Sol Dourdin,

Guyomard,

Rabiller

et al. 2024

Environ. Sci. Technol.

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Assessment of phytosanitary practices on the environment: case study potato of Loukkos (northwest Morocco)

Abbou

Chabbi

Benicha³

2023

Environ Monit Assess

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Loukkos perimeter is among the most important irrigated agricultural areas in Morocco. It covers horticulture and market garden production, including potato. This crop is characterized by the intensive use of pesticides that could lead to health and ecological risks, via the food chain and contamination of natural resources, including groundwater. This study aims to assess the use of pesticides in potato cultivation and their impacts on the environment and human health. Here, pesticide use was characterized by the number of treatments (NT), quantity of active substances indicator (QASI) and the treatment frequency indicator (TFI), through eld surveys carried out on 50 Loukkos potato producers. The results showed that farmers use heavy pesticide treatments, mainly against late blight. We determined NT = 19 treatments, total TFI = 28.10 and QASI = 14.86 kg/ha. These values re ect a massive use of pesticides on this crop, which could therefore constitute a challenge and a major constraint for the development of sustainable agriculture in this zone, due to their negative environmental and health effects. It is, therefore, necessary to react quickly to make changes in phytosanitary practices with the aim to monitoring pesticide use via the agro-environmental indicators to reduce health and environmental impact of intensive pesticide use.

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Assessment of pesticide use by determination of environmental indicators: case study of watermelon from Loukkos (Northwest Morocco)

Abbou,

Chabbi,

Benicha

2023

Euro-Mediterr J Environ Integr

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Pesticide mixture toxicity assessment through in situ and laboratory approaches using embryo-larval stages of the pacific oyster (Magallana gigas)

Cited by 6 publications

References 61 publications

Ancestors’ Gift: Parental Early Exposure to the Environmentally Realistic Pesticide Mixture Drives Offspring Phenotype in a Larger Extent Than Direct Exposure in the Pacific Oyster, Crassostrea gigas

Ancestors’ Gift: Parental Early Exposure to the Environmentally Realistic Pesticide Mixture Drives Offspring Phenotype in a Larger Extent Than Direct Exposure in the Pacific Oyster, Crassostrea gigas

Assessment of phytosanitary practices on the environment: case study potato of Loukkos (northwest Morocco)

Assessment of pesticide use by determination of environmental indicators: case study of watermelon from Loukkos (Northwest Morocco)

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