Pesticides Exposure by Air in Vineyard Rural Area and Respiratory Health in Children: A pilot study

Rahérison, Chantal; Baldi, Isabelle; Pouquet, Marie; Berteaud, Émilie; Mœsch, Christian; Bouvier, Ghislaine; Canal-Raffin, Mireille

doi:10.1016/j.envres.2018.11.002

Cited by 85 publications

(51 citation statements)

References 31 publications

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“…Significantly higher odds of allergies and hay fever were observed among children who lived on farms with pesticide use during pregnancy, compared to children living on farms with no pesticide use, but no relation was observed for cough, bronchitis and asthma [36]. Urinary ETU levels (as biomarkers for CM) were significantly associated with an increased risk of asthma and rhinitis, after adjustment, but no significant associations were found between lung function changes [44].…”

Section: Resultsmentioning

confidence: 89%

“…CM exposure (measured through urinary ETU) in a school located in a vineyard area with high pesticide use was significantly associated with an increased risk of asthma and rhinitis, but not of lung function changes [44].…”

Section: Resultsmentioning

confidence: 93%

“…Childhood respiratory symptoms, asthma prevalence and pulmonary function changes were associated with elemental sulfur applications within 0.5 and 1 km radii of the residence [42], but non-significant associations were observed for residential proximity to fumigants used in the same cohort [43]. Furthermore, one study explored the children's school proximity to the cultivation areas with pesticide use and respiratory effects, and found that urinary CM metabolite levels (by ETU concentration) were significantly associated with an increased risk of asthma and rhinitis [44].…”

Section: Resultsmentioning

confidence: 99%

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Respiratory and Allergic Effects in Children Exposed to Pesticides—A Systematic Review

Buralli

Dultra

Ribeiro

2020

IJERPH

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Pesticide exposure may affect children’s respiratory and allergic health, although results from epidemiological studies have not reached consensus. This review aims to analyze the scientific evidence on respiratory and allergic effects of exposure to agricultural pesticides in children aged up to 12 years old. The databases PubMed, Web of Science, Scielo, and Lilacs were screened to select articles published in English, Spanish, or Portuguese, and 21 articles were included in this review. Most investigations were conducted in North America (mostly in the United States), while no studies conducted in Latin America or Africa were found, despite their intensive use of pesticides. Children are exposed to pesticides through multiple pathways from the prenatal period throughout later developmental stages and may experience several respiratory effects. Most studies (79%) found positive associations with pesticide exposure and children’s respiratory and allergic effects such as asthma, wheezing, coughs, acute respiratory infections, hay fever, rhinitis, eczema, chronic phlegm, and lung function impairments. Contrastingly, 21% of the studies found no associations between pesticide exposure and children’s respiratory health. The vast differences among the characteristics of the studies hamper any comparison of the results. Exposure to pesticides may have several impacts on childhood respiratory health. More studies must be conducted, especially in low- and middle-income countries, preferably with comparable research protocols adapted to local realities. Efforts should be made to develop comprehensive risk mitigation strategies and behavioral interventions to reduce children’s exposure to pesticides used in agriculture and respiratory health effects, and to ensure healthy childhood growth.

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Section: Resultsmentioning

confidence: 89%

Section: Resultsmentioning

confidence: 93%

Section: Resultsmentioning

confidence: 99%

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Respiratory and Allergic Effects in Children Exposed to Pesticides—A Systematic Review

Buralli

Dultra

Ribeiro

2020

IJERPH

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“…Some EDCs are components of synthetic food products like food coloring additives, while others migrate into food from packaging [31,32]. Air can also bring EDCs to the respiratory system as air pollutants such as waste smoke from factories, household dust and aerosol sprays (pesticides and insecticides) [33]. Contaminated water bodies contribute to a wider dispersal.…”

Section: Introductionmentioning

confidence: 99%

Endocrine Disruptors Acting on Estrogen and Androgen Pathways Cause Reproductive Disorders through Multiple Mechanisms: A Review

Amir

Shah

Mamoulakis

et al. 2021

IJERPH

105

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Increasing contamination of the environment by toxic compounds such as endocrine disrupting chemicals (EDCs) is one of the major causes of reproductive defects in both sexes. Estrogen/androgen pathways are of utmost importance in gonadal development, determination of secondary sex characteristics and gametogenesis. Most of the EDCs mediate their action through respective receptors and/or downstream signaling. The purpose of this review is to highlight the mechanism by which EDCs can trigger antagonistic or agonistic response, acting through estrogen/androgen receptors causing reproductive defects that lead to infertility. In vitro, in vivo and in silico studies focusing on the impact of EDCs on estrogen/androgen pathways and related proteins published in the last decade were considered for the review. PUBMED and PUBCHEM were used for literature search. EDCs can bind to estrogen receptors (ERα and ERβ) and androgen receptors or activate alternative receptors such as G protein-coupled receptors (GPCR), GPR30, estrogen-related receptor (ERRγ) to activate estrogen signaling via downstream kinases. Bisphenol A, dichlorodiphenyltrichloroethane, dichlorodiphenyldichloroethylene, polychlorinated biphenyls and phthalates are major toxicants that interfere with the normal estrogen/androgen pathways leading to infertility in both sexes through many ways, including DNA damage in spermatozoids, altered methylation pattern, histone modifications and miRNA expression.

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“…One study among grape farmers in Greece reported a higher prevalence of AR among those who used pesticides 9 . Another study in France found that children living in areas surrounding vineyards had a higher rate of rhinitis symptoms (OR=3.56; 95% CI 1.04-12.12) 10 . In an occupational setting, a study found number of hours working in the greenhouse per day to be associated with rhinitis (OR, 1.85; 95% CI, 1.05-3.23) 11 .…”

Section: Introductionmentioning

confidence: 98%

Pesticide exposure and rhinitis: A cross-sectional study among farmers in Pitsanulok, Thailand

Juntarawijit

2021

F1000Res

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Background: Pesticide exposure has been suspected to cause rhinitis, a common disease that affects the health and wellbeing of millions of people around the world. The objective of this cross-sectional study was to examine the association between pesticide use and rhinitis prevalence among farmers in Phitsanulok province, Thailand. Methods: Data on pesticide use and rhinitis use were collected by an in-person interview questionnaire. Data from 9,649 participants were included in the analysis. The association between pesticide exposure and rhinitis was determined by multiple variable logistic regression, adjusted for potential confounding factors. Results: It was found that 6.3% of study participants had rhinitis, which was defined as having one or more of the following symptoms: sneezing, runny nose, and nasal congestion, within the past year. The study found each type of pesticide (insecticides, herbicides, fungicides, rodenticides, molluscicides) to be significantly associated with rhinitis, with the odds ratio ranging from 1.67 (95% CI 1.41-1.99) for the fungicide group to 7.19 (95% CI 4.67-11.06) for insecticide. For individual pesticides, the study found 33 out of 35 to be significantly associated with rhinitis with the OR values ranging from 1.30 (95% CI 1.00-1.69) for alachlor to 5.67 (95% CI 3.16-10.16) for Bordeaux mixture. Conclusions: This study found a prevalence of rhinitis among farmers in Phitsanulok, Thailand to be associated with the long-term exposure of many individual pesticides. This finding was consistent with other literature. Effects of pesticide on rhinitis should receive more attention from the public health and other organizations responsible for the farmers’ health.

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Pesticides Exposure by Air in Vineyard Rural Area and Respiratory Health in Children: A pilot study

Cited by 85 publications

References 31 publications

Respiratory and Allergic Effects in Children Exposed to Pesticides—A Systematic Review

Respiratory and Allergic Effects in Children Exposed to Pesticides—A Systematic Review

Endocrine Disruptors Acting on Estrogen and Androgen Pathways Cause Reproductive Disorders through Multiple Mechanisms: A Review

Pesticide exposure and rhinitis: A cross-sectional study among farmers in Pitsanulok, Thailand

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