Pesticides used in Europe and autism spectrum disorder risk: can novel exposure hypotheses be formulated beyond organophosphates, organochlorines, pyrethroids and carbamates? - A systematic review

Ongono, Jeanne Sandrine; Béranger, Rémi; Baghdadli, Amaria; Mortamais, Marion

doi:10.1016/j.envres.2020.109646

Cited by 48 publications

(29 citation statements)

References 76 publications

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“…Although epidemiological evidence supports a link between pesticides exposure and neurodevelopmental disorders (Hernández et al, 2016;Roberts et al, 2019;Von Ehrenstein et al, 2019), whether glyphosate may directly contribute to neurological sequel in humans needs further and significant investigation. A recent study points to a moderate level of evidence when associating glyphosate with autism spectrum disorders in humans (Ongono et al, 2020). One study indicates that prenatal or infant exposure to glyphosate, due to proximity to pesticides environmental sources, was associated with increased risk for autism spectrum disorders (Von Ehrenstein et al, 2019).…”

Section: Glyphosate and Neurological Risks: Environmental Experimental And Clinical Cluesmentioning

confidence: 99%

“…Currently, glyphosate can be detected in environmental and biological matrices, including water and human fluids (Myers et al, 2016;Niemann et al, 2015;Van Bruggen et al, 2018). Epidemiological studies have suggested a potential association between exposure to glyphosate and neurodevelopmental disorders, including autism (Garry et al, 2002;Ongono et al, 2020;Sealey et al, 2016;Von Ehrenstein et al, 2019). Experimentally, the neurotoxic effects of glyphosate were reported, although using high concentrations.…”

Section: Introductionmentioning

confidence: 99%

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Differential impact of dose-range glyphosate on locomotor behavior, neuronal activity, glio-cerebrovascular structures, and transcript regulations in zebrafish larvae

et al. 2021

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Highlights1. In zebrafish larvae, behavioral and brain electrophysiological defects elicit at high glyphosate concentrations.2. Neurological outcomes are not associated with structural neuro-vascular or muscular malformations.3. Morphological signs of microglia activation are reported after exposure to low and high glyphosate concentrations.4. Transcriptomic analysis reveals the deregulation of candidate pathways, possibly extending to neuronal vulnerability.

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Section: Glyphosate and Neurological Risks: Environmental Experimental And Clinical Cluesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Differential impact of dose-range glyphosate on locomotor behavior, neuronal activity, glio-cerebrovascular structures, and transcript regulations in zebrafish larvae

et al. 2021

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“…A population-based study in California of the United State (US) demonstrated that the risk of ASD might be associated with exposure of glyphosate during pregnancy and early childhood [ 8 ], suggesting a possible relationship between maternal glyphosate exposure and ASD in offspring [ 9 , 10 ]. A recent systemic review shows that glyphosate showed a “moderate level of evidence” in their association with ASD in children [ 11 ]. In a rodent study, we recently reported that maternal exposure to high dose of formulated glyphosate (Roundup Ⓡ Maxload) caused ASD-like behavioral abnormalities in male juvenile offspring [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Autism-like Behaviors in Male Juvenile Offspring after Maternal Glyphosate Exposure

Shan

et al. 2021

Clin Psychopharmacol Neurosci

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Objective: Exposure to the herbicide glyphosate during pregnancy and lactation may increase the risk for autism spectrum disorder (ASD) in offspring. Recently, we reported that maternal exposure of formulated glyphosate caused ASD-like behaviors in juvenile offspring. Here, we investigated whether maternal exposure of pure glyphosate could cause ASD-like behaviors in juvenile offspring. Methods: Water or 0.098% glyphosate was administered as drinking water from E5 to P21 (weaning). Behavioral tests such as grooming test and three-chamber social interaction test in male offspring were performed from P28 to P35. Results: Male offspring showed ASD-like behavioral abnormalities (i.e., increasing grooming behavior and social interaction deficit) after maternal exposure of glyphosate. Conclusion: The findings suggest that the exposure of glyphosate during pregnancy and lactation may cause ASD-like behavioral abnormalities in male juvenile offspring. It is likely that glyphosate itself, but not the other ingredients, may contribute to ASD-like behavioral abnormalities in juvenile offspring.

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“…If morphological and structural disorders of foetal development are developmental defects, which in most cases are incompatible with life, the functional disorders can occur at different stages of ontogenesis [1-6]. Analysis of many epidemiological studies indicates that there is a relationship between the effects of xenobiotics and the occurrence of NS pathology in children whose mothers were exposed to neurotoxicants during pregnancy [7][8][9]. The most common manifestations of such functional changes in children are autism, behavioural disorders, hyperactivity, inability to learn and various emotional problems [2,3,[7][8][9].Based on this, an important problem of modern preventive toxicology is the study of the possible impact of xenobiotics on the development of the nervous system in the pre-and postnatal periods.…”

mentioning

confidence: 99%

“…Analysis of many epidemiological studies indicates that there is a relationship between the effects of xenobiotics and the occurrence of NS pathology in children whose mothers were exposed to neurotoxicants during pregnancy [7][8][9]. The most common manifestations of such functional changes in children are autism, behavioural disorders, hyperactivity, inability to learn and various emotional problems [2,3,[7][8][9].…”

mentioning

confidence: 99%

Testing methods for the assessment of chemical neurotoxic effects on the developing organisms in pre- and postnatal period

Rashkivska

Nedopytanska

Zhminko

et al. 2021

OHNPU

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Aim of the research. Analysis of approaches to the assessment of neurotoxic effects of chemicals during ontogenesis. The dangerous tendency of the increase in the incidence of pathology of the nervous system in the child and the mother, who during pregnancy was exposed to neurotoxicants, necessitates the protection of the child’s body from such a negative effect of chemicals. One of the possible preventive ways to solve this problem is screening of xenobiotics before their widespread application, as well as identification of their ability to cause neurotoxic effects on the body during its development, and banning substances, neurotoxic effects of which on the development of progeny are proven. Materials and Methods. Detection of adverse effects at the stage of foetal development and then at the beginning of the functioning of a nervous system in the postnatal period requires complex experimental studies in laboratory animals, which are described in the recommendations of OECD guideline 426 (OECD Guideline for Testing of Chemicals; Guideline 426: Developmental Neurotoxicity Study, 2007). The OECD guideline 426 protocol provides for a wide range of methods for assessing sensory, motor, behavioural and cognitive functions. Conclusions. Analysis of data given in publications and methodological approaches to research and evaluation of neurotoxic effects of chemicals on the developing organism showed that to obtain representative results it is important to take into account all factors that may affect the result, select adequate informative tests and comply with all requirements. In Ukraine, international methodological approaches to the study of neurotoxic effects of pesticides on the body at the stage of development in the process of ontogenesis are applied at the L.I. Medved’s Research Center of Preventive Toxicology, Food and Chemical Safety, Ministry of Health, Ukraine (State Enterprise), Kyiv, Ukraine. Key Words: nervous system, neurotoxic effects, OECD guideline 426, neurobehavioral tests.

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Pesticides used in Europe and autism spectrum disorder risk: can novel exposure hypotheses be formulated beyond organophosphates, organochlorines, pyrethroids and carbamates? - A systematic review

Cited by 48 publications

References 76 publications

Differential impact of dose-range glyphosate on locomotor behavior, neuronal activity, glio-cerebrovascular structures, and transcript regulations in zebrafish larvae

Differential impact of dose-range glyphosate on locomotor behavior, neuronal activity, glio-cerebrovascular structures, and transcript regulations in zebrafish larvae

Autism-like Behaviors in Male Juvenile Offspring after Maternal Glyphosate Exposure

Testing methods for the assessment of chemical neurotoxic effects on the developing organisms in pre- and postnatal period

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