PET-CMR in heart failure - synergistic or redundant imaging?

Quail, Michael A.; Sinusas, Albert J.

doi:10.1007/s10741-017-9607-6

Cited by 12 publications

(9 citation statements)

References 81 publications

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“…Nonetheless, given a potential partial volume effect on PET, the larger size of a rat heart may be more suitable in the present study design 37 . In addition, such examinations in ZDF/ZL rats could also be conducted in recently introduced imaging modalities, such as (PET/)MRI or with the more commonly used TTE 38 . In particular, the latter imaging technique could also serve as a gold standard, in a manner similar to left-sided heart catherization 22 , 23 .…”

Section: Discussionmentioning

confidence: 99%

Left Ventricular Diastolic Dysfunction in a Rat Model of Diabetic Cardiomyopathy using ECG-gated 18F-FDG PET

Werner

Eissler

Hayakawa

et al. 2018

Sci Rep

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In diabetic cardiomyopathy, left ventricular (LV) diastolic dysfunction is one of the earliest signs of cardiac involvement prior to the definitive development of heart failure (HF). We aimed to explore the LV diastolic function using electrocardiography (ECG)-gated 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) imaging beyond the assessment of cardiac glucose utilization in a diabetic rat model. ECG-gated 18F-FDG PET imaging was performed in a rat model of type 2 diabetes (ZDF fa/fa) and ZL control rats at age of 13 weeks (n = 6, respectively). Under hyperinsulinemic-euglycemic clamp to enhance cardiac activity, 18F-FDG was administered and subsequently, list-mode imaging using a dedicated small animal PET system with ECG signal recording was performed. List-mode data were sorted and reconstructed into tomographic images of 16 frames per cardiac cycle. Left ventricular functional parameters (systolic: LV ejection fraction (EF), heart rate (HR) vs. diastolic: peak filling rate (PFR)) were obtained using an automatic ventricular edge detection software. No significant difference in systolic function could be obtained (ZL controls vs. ZDF rats: LVEF, 62.5 ± 4.2 vs. 59.4 ± 4.5%; HR: 331 ± 35 vs. 309 ± 24 bpm; n.s., respectively). On the contrary, ECG-gated PET imaging showed a mild but significant decrease of PFR in the diabetic rats (ZL controls vs. ZDF rats: 12.1 ± 0.8 vs. 10.2 ± 1 Enddiastolic Volume/sec, P < 0.01). Investigating a diabetic rat model, ECG-gated 18F-FDG PET imaging detected LV diastolic dysfunction while systolic function was still preserved. This might open avenues for an early detection of HF onset in high-risk type 2 diabetes before cardiac symptoms become apparent.

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Section: Discussionmentioning

confidence: 99%

Left Ventricular Diastolic Dysfunction in a Rat Model of Diabetic Cardiomyopathy using ECG-gated 18F-FDG PET

Werner

Eissler

Hayakawa

et al. 2018

Sci Rep

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“…Newer techniques for imaging and localization of HF, such as the use of Positron Emission Tomography -Cardiac Magnetic Resonance (PET-CMR), has a promising utility but is restricted due to its availability and economic feasibility [50]. It is necessary to develop diagnostic modalities that are economically viable and widely available.…”

Section: Discussionmentioning

confidence: 99%

A Beat Too Short: A Narrative Review of Heart Failure

Acharya¹,

Anoshina²,

Azike³

et al. 2018

Cardiol Cardiovascmed

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Background: Heart failure (HF) is one of the most common global public health concerns and a leading cause of death with the steadily increasing prevalence and substantial impact on quality of life. The objective of the article is to analyze various components of HF and discuss its determinants. Materials and Methods:A total of 50 articles was chosen for this literature review from sources such as EBSCO, PUBMED and Google Scholar.Results: Risk of developing HF is highest with coronary artery disease, diabetes, obesity, hypertension, and smoking respectively. Regardless of the precipitating factors, many compensatory mechanisms in our body serve only as a temporary fix. Most patients present with volume overload and normal or reduced cardiac output. Evaluation begins with a comprehensive history and examination, supported by the laboratory test. The major goals of treatment are to improve quality of life, alleviate symptoms, and reduce morbidity and mortality by reversing or slowing the cardiac and other vital organ dysfunction. Atrial fibrillation and ventricular arrhythmias are the most dreaded complications, and the prognosis is interlinked with associated comorbidities. Discussion: Currently, prescribed medications can improve the signs and symptoms HF. But it is necessary to develop and validate newer treatments, and early diagnostic modalities to enhance the quality of life. More research is needed to better organize and formulate patient-oriented plans when it comes to non-pharmacological treatment approach. A holistic approach is necessary to curb its growing incidence and address comorbidities, starting with health education and general screening.

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“…A positron is a positively charged nuclear particle that has the same mass as an electron. When an emitted positron collides with an electron, an annihilation reaction occurs, producing two gamma photons in opposite directions (Figure 1) [2]. PET detectors only register photon pairs that hit opposing detectors simultaneously.…”

Section: Introductionmentioning

confidence: 99%

“…PET detectors only register photon pairs that hit opposing detectors simultaneously. PET radionuclides generally have much shorter half-lives than those used in single photon emission computed tomography (SPECT), thus having less radiation exposure [2,3]. Furthermore, there is an advantage in terms of the spatial resolution of PET compared to SPECT [3].…”

Section: Introductionmentioning

confidence: 99%

Positron Emission Tomography in Heart Failure: From Pathophysiology to Clinical Application

Tersalvi

Beltrani

Grübler

et al. 2023

JCDD

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Imaging modalities are increasingly being used to evaluate the underlying pathophysiology of heart failure. Positron emission tomography (PET) is a non-invasive imaging technique that uses radioactive tracers to visualize and measure biological processes in vivo. PET imaging of the heart uses different radiopharmaceuticals to provide information on myocardial metabolism, perfusion, inflammation, fibrosis, and sympathetic nervous system activity, which are all important contributors to the development and progression of heart failure. This narrative review provides an overview of the use of PET imaging in heart failure, highlighting the different PET tracers and modalities, and discussing fields of present and future clinical application.

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PET-CMR in heart failure - synergistic or redundant imaging?

Cited by 12 publications

References 81 publications

Left Ventricular Diastolic Dysfunction in a Rat Model of Diabetic Cardiomyopathy using ECG-gated 18F-FDG PET

Left Ventricular Diastolic Dysfunction in a Rat Model of Diabetic Cardiomyopathy using ECG-gated 18F-FDG PET

A Beat Too Short: A Narrative Review of Heart Failure

Positron Emission Tomography in Heart Failure: From Pathophysiology to Clinical Application

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