Petrocortynes and petrosiacetylenes, novel polyacetylenes from a sponge of the genus Petrosia

Biosynthesis and function of polyacetylenes and allied natural products

“…The petrocortynes A-F (30A-C, 30I, 30K-L,Fig. 34) from the Korean South Sea are distinguished from the petroformynes by the presence of a 1,4-dialkyn-3-ol functionality in mid-chain and, with the exception of 30B, bear (R)-configurations at all assigned asymmetric centers [334,335]. The identification of the dideoxypetrosynols, petrotetrynols (30H, 30R-U, 30W), petrotriyndiol (30V), and the homologous and epimeric petrocortynes (30D-G, 30J, 30M, 30O, 30Q) greatly expanded the number of observed alcohol configurations, chain lengths, and levels of desaturation (Fig.…”

Identification of Novel Acetylenic Alcohols and a New Dihydrothiopyranone from the Tropical Sponge Reniochalina sp.

“…Acetylenic alcohols, a group of sponge metabolites, exhibit great structural variations in chain length and functional groups [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18]. Most of these compounds have shown various interesting bioactivities such as brine shrimp lethality [1], cytotoxicity [2][3][4][5][6][9][10][11][12][13][14], a-glucosidase inhibition [15] and HIV-1 integrase inhibition [16].…”

“…Most of these compounds have shown various interesting bioactivities such as brine shrimp lethality [1], cytotoxicity [2][3][4][5][6][9][10][11][12][13][14], a-glucosidase inhibition [15] and HIV-1 integrase inhibition [16].…”

Structure Elucidation and Cytotoxic Evaluation of New Polyacetylenes from a Marine Sponge Petrosia sp.

“…In recent years, a series of new polyacetylenes was isolated from a marine sponge of the Petrosia sp [5,7,8,9,10,11,12,13,14,15,16,20,21,22,23,24,25]. Some of these polyacetylenic compounds have been found to possess significant cytotoxicity [5,7,9,14,15,20,21,24].…”