Identification of Novel Acetylenic Alcohols and a New Dihydrothiopyranone from the Tropical Sponge <i>Reniochalina</i> sp.

Lee, Hyi‐Seung; Lee, Ji Hye; Won, Hoshik; Park, Song‐Kyu; Kim, Hwan Mook; Shin, Hee Jae; Park, Heung Sik; Sim, Chung Ja; Kim, Hyekyeong

doi:10.1007/s11745-008-3249-3

Cited by 16 publications

(9 citation statements)

References 24 publications

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“…Furthermore, highlights about the therapeutic lead potential of such structures have been discussed in recent reviews, 13,25 including the outcome that one compound (see I in Figure S10) exhibited a small in vivo T/C = 130% against IGROV-1 (human ovarian) cancer cells in athymic mice. 26 Based on previous findings (see structures II , 27 IV , 26 VI 19 and VIII , 28 Figure S10), compounds containing substructure A , present in all of our isolates ( 1–9 ), would be expected to exhibit low to sub-micromolar in vitro cytotoxicity to a range of solid tumor cancer cells. Unknown from the literature were the responses to be expected for these compounds against non-proliferating normal cells.…”

Section: Resultssupporting

confidence: 57%

“…13 At this juncture the prospects for further therapeutic lead development of the active pharmacophore associated with substructure A continues to be a challenge. The major issues include: (a) potent but indiscriminant cytotoxicity, demonstrated above, accompanied by broad toxicity to mammalian cells, (b) contradictory patterns of structure-related cytotoxicity (as shown by three sets of entries in Figure S10: see II vs. III , 27 IV vs. V , 26 and VIII vs. IX 28 ), (c) general compound instability, and (d) incomplete understanding about the molecular target associated with their cytotoxicity. 13 …”

Section: Resultsmentioning

confidence: 99%

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Structures and Cytotoxic Evaluation of New and Known Acyclic Ene-Ynes from an American Samoa Petrosia sp. Sponge

et al. 2013

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Four new compounds, (−)-petrosynoic acids A–D (1–4), and five known congeners, pellynols A (5), C (6), D (7), F (8), and I (9) were isolated from a Petrosia sp. marine sponge collected in American Samoa. Isolation work was guided by cytotoxicity against human lung cancer cells (H460). The structures of the C31-C33 polyacetylenes (1–9) were determined on the basis of 1D- and 2D-NMR analysis, mass spectrometry, and comparison of specific rotation values. Compounds 1–9 were found to be broadly cytotoxic with limited selectivity for cancer cells as they were all moderately active against the A2058 (melanoma), H522-T1 (lung), and H460 (lung) human cancer cell lines as well as IMR-90 quiescent human fibroblast cells.

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Section: Resultssupporting

confidence: 57%

Section: Resultsmentioning

confidence: 99%

Structures and Cytotoxic Evaluation of New and Known Acyclic Ene-Ynes from an American Samoa Petrosia sp. Sponge

et al. 2013

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“…The four heptapeptides (A–D) were inactive against the tested cell lines. This report has drawn attention to the marine secondary metabolites from the sponges of the genus Reniochalina , which was previously dominated by dihydrothiopyranone, fatty acids, and acetylenic alcohols [ 89 , 90 , 91 ]. Recently isolated anticancer cyclic peptides were listed in Figure 4 .…”

Section: Recently Reported Naturally Occurring Bioactive Cyclopeptmentioning

confidence: 99%

Natural Cyclic Peptides as an Attractive Modality for Therapeutics: A Mini Review

2018

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Peptides are important biomolecules which facilitate the understanding of complex biological processes, which in turn could be serendipitous biological targets for future drugs. They are classified as a unique therapeutic niche and will play an important role as fascinating agents in the pharmaceutical landscape. Until now, more than 40 cyclic peptide drugs are currently in the market, and approximately one new cyclopeptide drug enters the market annually on average. Interestingly, the majority of clinically approved cyclic peptides are derived from natural sources, such as peptide antibiotics and human peptide hormones. In this report, the importance of cyclic peptides is discussed, and their role in drug discovery as interesting therapeutic biomolecules will be highlighted. Recently isolated naturally occurring cyclic peptides from microorganisms, sponges, and other sources with a wide range of pharmacological properties are reviewed herein.

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“…(Lee et al, 2009). These exhibited a significant growth inhibiting effect against human tumor cell lines.…”

Section: Alcohols With Both Double and Triple Bondsmentioning

confidence: 99%

Toxic Alcohols: Aliphatic Unsaturated Alcohols

Patočka¹,

Nepovímová²,

Kuča³

2016

MMSL

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SummaryShort-chain unsaturated aliphatic alcohols exist as volatile liquids, some of them are used in both industrial and non-industrial environments, and some of them are natural products of different organisms. These alcohols very often work as semiochemicals, including acting as pheromones, attractants, repellents, etc.. Long-chain poly-unsaturated alcohols are often toxic principals of certain plants, thereby presenting a risk to humans.

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Identification of Novel Acetylenic Alcohols and a New Dihydrothiopyranone from the Tropical Sponge Reniochalina sp.

Cited by 16 publications

References 24 publications

Structures and Cytotoxic Evaluation of New and Known Acyclic Ene-Ynes from an American Samoa Petrosia sp. Sponge

Structures and Cytotoxic Evaluation of New and Known Acyclic Ene-Ynes from an American Samoa Petrosia sp. Sponge

Natural Cyclic Peptides as an Attractive Modality for Therapeutics: A Mini Review

Toxic Alcohols: Aliphatic Unsaturated Alcohols

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