Petroleum ether extract of Cnidium monnieri ameliorated scopolamine-induced amnesia through adrenal gland-mediated mechanism in male rats

Wu, Chi‐Rei; Li, Lin; Hsieh, Chia Ling; Wang, Wen Hsin; Lin, Yung Ta; Hsieh, Μing-Tsuen

doi:10.1016/j.jep.2008.02.013

Cited by 12 publications

(14 citation statements)

References 15 publications

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“…Each animal was placed individually at the apparatus and observed for 10 min to record the movement time, length and velocity (locomotor activity), entries into the hole and time spent (exploratory activity) by TruScan software v 2.07 (Coulbourn Instruments L.L.C., PA, USA) [15]. …”

Section: Methodsmentioning

confidence: 99%

“…Twenty-four hours later, the retention trial (day 9) was conducted. The rat was again placed in the light compartment, the door was opened and the step-through latency was recorded as a measure of memory retention [15]. An upper cut-off time of 300 sec was set.…”

Section: Methodsmentioning

confidence: 99%

“…If unsuccessful within the aborted time period, the rat was given a score of 120 sec and then physically placed on the platform and allowed the 30-sec rest period. In either case, the rat was immediately given the next trial after the rest period [15]. The day following four daily sessions (day 14), the probe test was performed as a measure of reference memory.…”

Section: Methodsmentioning

confidence: 99%

“…The Plexiglass platform was removed from the pool, and each rat was released from the quadrant opposite to where the platform had been located. The parameters measured from probe test during 60 s were time and distance in each quadrant especial spent searching for the platform in the training quadrant, and swimming speed [15]. …”

Section: Methodsmentioning

confidence: 99%

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Reversal by aqueous extracts of Cistanche tubulosa from behavioral deficits in Alzheimer’s disease-like rat model: relevance for amyloid deposition and central neurotransmitter function

Lin

2014

BMC Complement Altern Med

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BackgroundCistanche tubulosa (Schenk) R. Wight (CT) is commonly used to treat forgetfulness by traditional Chinese physicians. This study presents the ameliorating effects of CT extract which was quantified with three phenylpropanoid glycosides in Alzheimer’s disease (AD)-like rat model.MethodsAmyloid β peptide 1-42 (Aβ 1-42) intracisternally infused to rats by osmotic pump (Alzet 2002) was used as an AD-like rat model. The major pathological makers were measured including Aβ 1-42 immunohistochemical stain, behavioral tests (inhibitory avoidance task and Morris water maze) and central neurotransmitter functions.ResultsAβ 1-42 caused the cognitive deficits, the increase in the amyloid deposition and acetylcholinesterase activities, and the decrease in the levels of brain’s acetylcholine and dopamine. Daily administration of CT extract throughout Aβ 1-42 infusion periods ameliorated the cognitive deficits, decreased amyloid deposition and reversed cholinergic and hippocampal dopaminergic dysfunction caused by Aβ 1-42. Donepezil also ameliorated the cognitive dysfunction, but only blocked the amyloid deposition and cholinergic dysfunction caused by Aβ 1-42.ConclusionsWe suggest that CT extract, containing enough echinacoside and acteoside, ameliorated the cognitive dysfunction caused by Aβ 1-42 via blocking amyloid deposition, reversing cholinergic and hippocampal dopaminergic neuronal function.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Reversal by aqueous extracts of Cistanche tubulosa from behavioral deficits in Alzheimer’s disease-like rat model: relevance for amyloid deposition and central neurotransmitter function

Lin

2014

BMC Complement Altern Med

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“…Osthole (7-methoxy-8-(3-methylpent-2-enyl) coumarin, Ost) (Figure 1) is extracted from Cnidium monnieri (L.), Cusson and Angelica pubescens maxin. To date, the antitumor [22], anticonvulsant [23] and memory-enhancing [24] activities of Ost have been demonstrated. Recently, this herbal compound has also been found to exhibit potent anti-inflammatory properties through the inhibition of cyclooxygenase (COX), inducible-nitric oxide synthase (iNOS) and tumor necrosis factor-α (TNF-α) [25].…”

Section: Introductionmentioning

confidence: 99%

Osthole, a herbal compound, alleviates nucleus pulposus-evoked nociceptive responses through the suppression of overexpression of acid-sensing ion channel 3 (ASIC3) in rat dorsal root ganglion

Chen

Qin

et al. 2012

Med Sci Monit

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SummaryBackgroundOsthole (Ost), a natural coumarin derivative, has been shown to inhibit many pro-inflammatory mediators and block voltage-gated Na+ channels. During inflammation, acidosis is an important pain inducer which activates nociceptors by gating depolarizing cationic channels, such as acid-sensing ion channel 3 (ASIC3). The aim of this study was to examine the effects of Ost on nucleus pulposus-evoked nociceptive responses and ASIC3 over-expression in the rat dorsal root ganglion, and to investigate the possible mechanism.Material/MethodsRadicular pain was generated with application of nucleus pulposus (NP) to nerve root. Mechanical allodynia was evaluated using von Frey filaments with logarithmically incremental rigidity to calculate the 50% probability thresholds for mechanical paw withdrawal. ASIC3 protein expression in dorsal root ganglions (DRGs) was assessed with Western blot and immunohistochemistry. Membrane potential (MP) shift of DRG neurons induced by ASIC3-sensitive acid (pH6.5) was determined by DiBAC4 (3) fluorescence intensity (F.I.).ResultsThe NP-evoked mechanical hyperalgesia model showed allodynia for 3 weeks, and ASIC3 expression was up-regulated in DRG neurons, reaching peak on Day 7. Epidural administration of Ost induced a remarkable and prolonged antinociceptive effect, accompanied by an inhibition of over-expressed ASIC3 protein and of abnormal shift of MP. Amiloride (Ami), an antagonist of ASIC3, strengthened the antinociceptive effect of Ost.ConclusionsUp-regulation of ASIC3 expression may be associated with NP-evoked mechanical hyperalgesia. A single epidural injection of Ost decreased ASIC3 expression in DGR neurons and the pain in the NP-evoked mechanical hyperalgesia model. Osthole may be of great benefit for preventing chronic pain status often seen in lumbar disc herniation (LDH).

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Osthole improves chronic cerebral hypoperfusion induced cognitive deficits and neuronal damage in hippocampus

Wang

et al. 2010

European Journal of Pharmacology

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Petroleum ether extract of Cnidium monnieri ameliorated scopolamine-induced amnesia through adrenal gland-mediated mechanism in male rats

Cited by 12 publications

References 15 publications

Reversal by aqueous extracts of Cistanche tubulosa from behavioral deficits in Alzheimer’s disease-like rat model: relevance for amyloid deposition and central neurotransmitter function

Reversal by aqueous extracts of Cistanche tubulosa from behavioral deficits in Alzheimer’s disease-like rat model: relevance for amyloid deposition and central neurotransmitter function

Osthole, a herbal compound, alleviates nucleus pulposus-evoked nociceptive responses through the suppression of overexpression of acid-sensing ion channel 3 (ASIC3) in rat dorsal root ganglion

Osthole improves chronic cerebral hypoperfusion induced cognitive deficits and neuronal damage in hippocampus

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