Peyer’s Patch: Targeted Drug Delivery for Therapeutics Benefits

Patel, Rakesh P.; Shah, Pranav; Barve, Kalyani; Patel, Nikunjana A.; Gandhi, Jaimini

doi:10.1007/978-981-13-3642-3_5

Cited by 4 publications

(9 citation statements)

References 104 publications

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“…As already described above, polymeric nanoparticles trap hydrophobic bioactive agents inside a 3D network structure, preventing enzymatic degradation occurring over the GI tract and delivering the intact drug with unchanged PP levels [137,138]. Size, shape, surface properties, and surface charge deeply influence the rate and length of PP absorption.…”

Section: Peyer's Patchesmentioning

confidence: 99%

“…This fact allows not only the active agent to be presented in a solution form in the gut, but also, since SMEDDSs do not need biliary salts and enzymes to be digested, limits possible absorption alterations due to individual variability. Lastly, enhancing drug solubilization and improving lymphatic target efficiency of SMEDDSs increases membrane permeability in the GI tract and lymphatic uptake of drugs, thus lowering the drug amount required to have a clinical effect and reducing the systemic side effects, thereby improving patient compliance and cost of therapy [137]. Several studies conducted on animals have agreed, finding a meaningful increase in absorption and bioavailability when curcumin SMEDDS formulation is compared to unformulated curcumin [147][148][149][150][151].…”

Section: Peyer's Patchesmentioning

confidence: 99%

“…Peryer's patches (PPs) are lymphoid nodules that aggregate in follicular structures that cover the ileum portion of the small intestine, giving birth to the gut-associated lymphoid tissue (GALT). PP follicles consist of a core containing B lymphocytes, dendritic cells, and macrophages that are detached from the intestinal lumen by a specific layer, the follicle-associated epithelium (FAE), which incorporates enterocytes, goblet cells, and modified epithelial cells termed microfold cells (M cells) [136,137]. M cells are specialized enterocytes whose role is to bind and transfer xenobiotics from the lumen to the underlying immune cells, which then ignore or trigger the immune response depending on the antigen being processed [137].…”

Section: Peyer's Patchesmentioning

confidence: 99%

“…PP follicles consist of a core containing B lymphocytes, dendritic cells, and macrophages that are detached from the intestinal lumen by a specific layer, the follicle-associated epithelium (FAE), which incorporates enterocytes, goblet cells, and modified epithelial cells termed microfold cells (M cells) [136,137]. M cells are specialized enterocytes whose role is to bind and transfer xenobiotics from the lumen to the underlying immune cells, which then ignore or trigger the immune response depending on the antigen being processed [137]. Although several studies have already taken PPs into consideration for drug-targeting purposes [138][139][140], most of the orally administered drugs still get metabolized before reaching the systemic circulation, unless selective uptake occurs in lymph.…”

Section: Peyer's Patchesmentioning

confidence: 99%

“…In consequence, non-ionized, hydrophobic nanoparticles, sized below 1 µm (more precisely below 200 nm) are easily transcytosed by M cells. Furthermore, surface functionalization with specific M cells ligands, such as lecithin, IgA, or antibodies, enables more specific targeting [136,137]. Despite these characteristics, the main issue with M cells uptake remains the integrity of the substance reaching the intestinal wall, thanks to carriers specifically tailored for the purpose.…”

Section: Peyer's Patchesmentioning

confidence: 99%

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Improving Curcumin Bioavailability: Current Strategies and Future Perspectives

2021

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Curcumin possesses a plethora of interesting pharmacological effects. Unfortunately, it is also characterized by problematic drug delivery and scarce bioavailability, representing the main problem related to the use of this compound. Poor absorption, fast metabolism, and rapid systemic clearance are the most important factors contributing to low curcumin levels in plasma and tissues. Accordingly, to overcome these issues, numerous strategies have been proposed and are investigated in this article. Due to advances in the drug delivery field, we describe here the most promising strategies for increasing curcumin bioavailability, including the use of adjuvant, complexed/encapsulated curcumin, specific curcumin formulations, and curcumin nanoparticles. We analyze current strategies, already available in the market, and the most advanced technologies that can offer a future perspective for effective curcumin formulations. We focus the attention on the effectiveness of curcumin-based formulations in clinical trials, providing a comprehensive summary. Clinical trial results, employing various delivery methods for curcumin, showed that improved bioavailability corresponds to increased therapeutic efficacy. Furthermore, advances in the field of nanoparticles hold great promise for developing curcumin-based complexes as effective therapeutic agents. Summarizing, suitable delivery methods for this polyphenol will ensure the possibility of using curcumin-derived formulations in clinical practice as preventive and disease-modifying therapeutics.

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Section: Peyer's Patchesmentioning

confidence: 99%

Section: Peyer's Patchesmentioning

confidence: 99%

Section: Peyer's Patchesmentioning

confidence: 99%

Section: Peyer's Patchesmentioning

confidence: 99%

Section: Peyer's Patchesmentioning

confidence: 99%

See 3 more Smart Citations

Improving Curcumin Bioavailability: Current Strategies and Future Perspectives

2021

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Understanding lymphatic drug delivery through chylomicron blockade: A retrospective and prospective analysis

Yousef,

Bou-Chacra,

Löbenberg

et al. 2024

Journal of Pharmacological and Toxicological Methods

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Synthesis of selenium nanoparticles with the use of "green" technologies

Цехмістренко

Bityutskyy

Tsekhmistrenko

et al. 2022

Tehnologìâ virobnictva ì pererobki produktìv tvarinnictva

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Traditional selenium supplements are usually highly toxic and have low levels of absorption, so developing systems that are using selenium compounds as a carrier to increase the bioavailability of the element and control its release in the body is extremely important. Nano-sized selenium is of great interest as a dietary supplement, especially in selenium-deficient states, as well as as a therapeutic agent without significant adverse effects. Emphasis is placed on the incorporation of nanotechnologi cal applications, the study of an effective route of administration, and generalized knowledge about selenium nanoparticles, their biological effects and advantages, and mechanisms of absorption. Nanotechnical modifications of nanoparticles, the use of SeNPs as a nutritional supplement, and the effects they exert on the body are considered. Various methods for the synthesis of SeNPs are considered. The study focuses on the problems of traditional forms of dietary selenium and the benefits of SeNPs. The mechanisms of nanoparticles passage through the intestinal mucosa and the features of their oral administration are elucidated. The presented materials prove that the importance of Selenium lays on regulation in the composition of selenoproteins of many physiological processes, influence on the productive and reproductive properties. Correction of selenium content in the diet prevents a number of selenium deficiency diseases, and selenium in nano form is most appropriate for use because of its high bioavailability and low toxicity, which is especially relevant for ruminants. Further preclinical and clinical studies in vitro and in vivo will enable the development of novel nanopreparative systems for transport in selenium, alter the physicochemical properties of SeNPs, increase their stability in the gastrointestinal tract for controlled release of the element to provide dietary and therapeutic benefits. Key words: nanoparticles, selenium, biomedicine, oxidative stress, biomedical application of nanoparticles.

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Peyer’s Patch: Targeted Drug Delivery for Therapeutics Benefits

Cited by 4 publications

References 104 publications

Improving Curcumin Bioavailability: Current Strategies and Future Perspectives

Improving Curcumin Bioavailability: Current Strategies and Future Perspectives

Understanding lymphatic drug delivery through chylomicron blockade: A retrospective and prospective analysis

Synthesis of selenium nanoparticles with the use of "green" technologies

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