Peyer’s Patches and the Early Development of B Lymphocytes

Reynolds, John D.

doi:10.1007/978-3-642-71851-9_3

Cited by 46 publications

(29 citation statements)

References 43 publications

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“…Peyer's patches, which occur principally in the ileum, play an important role in the induction and propagation of immune responses in the intestinal mucosa. According to Reynolds, Peyer's patches in pigs may also play the role of primary lymphoid organs for B cells (Reynolds 1987).…”

Section: Discussionmentioning

confidence: 99%

The effect of T-2 toxin on percentages of CD4+, CD8+, CD4+CD8+ and CD21+ lymphocytes, and mRNA expression levels of selected cytokines in porcine ileal Peyer’s patches

Obremski

Podlasz²,

Żmigrodzka³

et al. 2013

Polish Journal of Veterinary Sciences

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The immune system is one of the main toxicity targets of the T-2 toxin. In view of scant research data demonstrating the effect of T-2 on cellular and humoral responses in gut-associated lymphoid tissue (GALT), this study set out to investigate the effects of chronic exposure to low doses of the T-2 toxin (200 μg T-2 toxin kg -1 feed) on percentages of CD4 + and CD8 + T lymphocytes, CD4 + /CD8 + double-positive T lymphocytes, CD21 + B cells, and IL-2, IFN-γ, IL-4 and IL-10 mRNA expression levels in porcine ileal Peyer's patches. The investigated material comprised ileum sections sampled from piglets (aged 8-10 weeks, body weight of 15-18 kg) on days 14, 28 and 42 of the experiment.After 42 days of exposure to T-2, a significant drop in the quantity of the IL-10 product was observed (R=0.94; S.E. 0.49-0.79; p<0.001). A gradual decrease in the amount of IL-4 and IFN-γ cytokine transcripts was found throughout the experiment, but the reported trend was not significant. On experimental days 14 and 42, a significant increase in the percentage of CD8 + T lymphocytes was observed in comparison with the control (p=0.04 and p=0.05, respectively), whereas on day 28, a significant decrease in the percentage of the above subpopulation was noted (p=0.00). The percentage of CD21 + B cells in the experimental group decreased steadily in comparison with the control, and the observed drop was significant on days 28 and 42 (p=0.06 and p=0.00, respectively). On days 14 and 28, the percentages of CD4 + and CD8 + T lymphocytes were lower in the experimental animals than in the control group, and the drop reported on day 28 was statistically significant (p=0.03).

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Section: Discussionmentioning

confidence: 99%

The effect of T-2 toxin on percentages of CD4+, CD8+, CD4+CD8+ and CD21+ lymphocytes, and mRNA expression levels of selected cytokines in porcine ileal Peyer’s patches

Obremski

Podlasz²,

Żmigrodzka³

et al. 2013

Polish Journal of Veterinary Sciences

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“…At birth 25 to 40 JPP are found and one IPP which may reach a length of 3 m in 2 month old lambs [19]. Vigorous lymphopoiesis occurs prenatally and reaches a maximum in 2 to 3 month old lambs [100]. Thereafter the IPP involutes and disappears at about 15 month.…”

Section: Distribution Ontogeny and Amountmentioning

confidence: 98%

MALT structure and function in farm animals

2006

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-Mucosa-associated lymphoid tissue (MALT) is defined as an organized lymphoid tissue in the mucosa that samples antigens. The morphological characteristics that distinguish MALT from lymphoid infiltrates are discussed. MALT has been extensively investigated in laboratory animals, while knowledge in cattle, sheep, goats, pigs and horses that are summarized under the term farm animals in this review is fragmentary. Literature data about the distribution, morphology, function and involvement in infectious diseases of MALT in farm animals are described. The understanding of specific features of MALT in other species than laboratory animals is important for comparative research, in order to understand pathological and immunological processes in the respective species and as a potential route of vaccination of mucosal surfaces.

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“…Even though ileal and jejunal Peyer's patches are morphologically similar, Pabst et al (1988) concluded that there is a greater lymphocyte production rate, a greater number of total germinal follicles, and a greater mean follicle diameter in ileal Peyer's patches compared with jejunal Peyer's patches. In addition, although human and mouse ileal Peyer's patches have been established as secondary lymphoid organs, there is evidence to suggest that ileal Peyer's patches in sheep, cattle, and swine exhibit properties consistent with a function as primary B-cell lymphoid organs (Reynolds, 1987;Parng et al, 1996;Andersen et al, 1999). Considering the species differences, differences in B and T lymphocyte distribution, quantity, and function, the Peyer's patch is a complex lymphoid aggregate that has multiple functions.…”

Section: Galt Inductive Sitesmentioning

confidence: 99%

BOARD-INVITED REVIEW: Porcine mucosal immunity of the gastrointestinal tract1

Burkey

Skjolaas²,

Minton

2009

Journal of Animal Science

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ABSTRACT:The gastrointestinal tract (GIT) constitutes one of the largest immunological organs of the body. The GIT must permit absorption of nutrients while also maintaining the ability to respond appropriately to a diverse milieu of dietary and microbial antigenic components. Because of the diverse population of antigenic components within the GIT, a sophisticated mucosal immune system has evolved that relies on collaboration between the innate and adaptive arms of immunity. The collaborative, mucosal immune effort offers protection from harmful pathogens while also being tolerant of dietary antigens and normal microbial flora. Knowledge with respect to porcine mucosal immunity is important as we strive to understand the interrelationships among GIT physiology, immunology, and the resident microbiota. The aim of this review is to provide a descriptive overview of GIT immunity and components of the mucosal immune system and to highlight differences that exist between the porcine species and other mammals.

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Peyer’s Patches and the Early Development of B Lymphocytes

Cited by 46 publications

References 43 publications

The effect of T-2 toxin on percentages of CD4+, CD8+, CD4+CD8+ and CD21+ lymphocytes, and mRNA expression levels of selected cytokines in porcine ileal Peyer’s patches

The effect of T-2 toxin on percentages of CD4+, CD8+, CD4+CD8+ and CD21+ lymphocytes, and mRNA expression levels of selected cytokines in porcine ileal Peyer’s patches

MALT structure and function in farm animals

BOARD-INVITED REVIEW: Porcine mucosal immunity of the gastrointestinal tract1

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