Peyronie’s disease: a literature review on epidemiology, genetics, pathophysiology, diagnosis and work-up

Althakafi, Sultan; Alhathal, Naif

doi:10.21037/tau.2016.04.05

Cited by 93 publications

(53 citation statements)

References 67 publications

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“…İleri yaşın yanı sıra ED'li diabetik hastalar ya da radikal prostatektomili hastalarda olduğu gibi bazı subpopülasyonlarda prevalans artabilmektedir. [6,14] Etiyolojisi tam olarak bilinmese de PH'nin genetik olarak iletildiği ve tekrarlayan penil travmaya sekonder geliştiği konusunda genel bir fikir birliği vardır. [15,16] TUNIKA ALBUGINEA'NIN YAPISI Peyronie hastalığının etiyolojisinin incelenmesinde ve anlaşılmasında korpora kavernosa (KK) ve TA anatomi ve histolojisine ilişkin bazı bilgileri gözden geçirmek önem kazanmaktadır.…”

Section: öZunclassified

Peyronie hastalığı patofizyolojisi

Ateş¹,

Gökçe²

2019

Androl Bul

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Peyronie hastalığı'nın (PH) uzun tarihi boyunca birçok faktör bu hastalığın potansiyel nedeni olarak öne sürülmüştür. Yedinci yüzyılda yaşamış bir Bizans imparatoru olan Heraklius'un epispadik bir meaya ve dorsal kurvatürü olan bir penise sahip olduğu ve yüzüne doğru işeyip, boşaldığı bilinmektedir. Onun bu durumu dönemin insanları tarafından öz yeğeni ile yapmış olduğu ensest evlilik ile ilişkilendirilmiş ve tanrının bir gazabı olarak görülmüştür. [1,2] Theodoric isimli bir araştırmacı 1267 yılında penis ABSTRACT Peyronie's disease (PD) is a progressive localized fibrotic disease of tunica albuginea (TA) in the penis. It is also considered as a wound healing disorder with fibrous and non-elastic scar formation and calcified plaque formation. Clinically, these plaques can cause deformities such as curvature, shortening and contraction of the penis and pain. Although the complete spectrum of etiologic factors for PD is unknown, multiple mechanisms have been proposed including trauma, impaired fibrin clearance, autoimmune and genetic factors. It is thought that delamination of bilaminar TA in the penis with repetitive microtrauma and subsequent inflammatory process may cause the development of the Peyronie plaques. The post-traumatic inflammatory process causes myofibroblast persistence and subsequent abnormal collagen accumulation. Accompanying abnormal fibrin accumulation and irregular form of elastic fibers, characteristic tunical fibrous plaque and scar formation occur and the inflammatory process is completed. Pathogenesis of PD has been tried to be demonstrated in animal models, cell cultures and clinical studies. A better understanding of the etiopathology of this disease is important for the development of treatment strategies.

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Section: öZunclassified

Peyronie hastalığı patofizyolojisi

Ateş¹,

Gökçe²

2019

Androl Bul

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“…Peyronie’s “plaque” (scar) results from abnormal extracellular matrix production through upregulation of myofibroblast activity and tissue inhibitors of matrix metalloproteinases, among other mechanisms 8,9 . There is a link between personal or family history of PD and Dupuytren’s contractures, suggesting a genetic predisposition 10,11 …”

Section: Introductionmentioning

confidence: 99%

Peyronie’s disease: Contemporary evaluation and management

2020

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Peyronie's disease is a common yet poorly understood condition characterized by penile pain, curvature, sexual dysfunction and psychological bother. Peyronie's disease represents a penile wound healing disorder, and is thought to arise from exuberant scarring in response to penile trauma in genetically predisposed men. In the absence of active treatment, the majority of men experience stable or worsening symptoms, with few reporting spontaneous resolution in penile curvature or other deformity. In contrast, penile pain improves or resolves in the majority of men. Treatment options vary based on symptom severity and stability. Several oral therapies are commonly prescribed, although to date there are no strong data to support any oral agents as monotherapy for Peyronie's disease. Other options including penile traction therapy and intralesional injections result in modest improvements for many patients, particularly when used early after symptom onset. Penile straightening through approaches, such as penile plication and plaque incision or partial excision and grafting, represent the most rapid and reliable approach to correct penile curvature once the symptoms have stabilized. Side-effects vary based on the type of surgery carried out, and include penile shortening, sensation changes and erectile dysfunction in the minority of men. In patients with drug refractory erectile dysfunction and Peyronie's disease, placement of a penile prosthesis will address both issues, and is associated with high levels of patient satisfaction. The current review provides a practical approach to the modern evaluation and management of patients presenting with Peyronie's disease.

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“…An increasing knowledge of the pathophysiology [3] of the disease has urged clinical researchers to propose intralesional treatments [4] such as verapamil [5] and interferon alpha 2B [6] which remain off label, or collagenase clostridium histolycum (CCH) ( Xiapex ® ) which obtained an FDA approval [7] for Peyronie's disease (PD). The interesting improvement rates observed with these treatments are challenged by side effects such as corporeal ruptures for CCH, flu-like symptoms for interferon alpha 2B, or penile bruising, dizziness and nausea for verapamil.…”

Section: Introductionmentioning

confidence: 99%