pH and ultrasound dual-responsive drug delivery system based on PEG–folate-functionalized Iron-based metal–organic framework for targeted doxorubicin delivery

Ahmed, Ahmed; Karami, Abdollah; Sabouni, Rana; Husseini, Ghaleb A.; Paul, Vinod K.

doi:10.1016/j.colsurfa.2021.127062

Cited by 33 publications

(9 citation statements)

References 41 publications

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“…Paul group functionalized PEG and FA on the NH 2 ‐Fe‐BDC MOF, which was constructed from iron metal clusters and 2‐amino‐1,4‐benzenedicarboxylic acid (NH 2 ‐BDC) organic linker. As a result, they improved not only the colloidal stability, but also the targeting ability to MCF‐7 cells, which overexpressed FR on their surface (Ahmed et al, 2021). The MTT result revealed the low cytotoxic activity of this platform at concentrations relevant to their use in vivo and future clinical trials.…”

Section: Mofs Drug Delivery Performancementioning

confidence: 99%

Trend in biodegradable porous nanomaterials for anticancer drug delivery

Đoàn

2023

WIREs Nanomed Nanobiotechnol

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In recent years, biodegradable nanomaterials have exhibited remarkable promise for drug administration to tumors due to their high drug-loading capacity, biocompatibility, biodegradability, and clearance. This review will discuss and summarize the trends in utilizing biodegradable nanomaterials for anticancer drug delivery, including biodegradable periodic mesoporous organosilicas (BPMOs) and metal-organic frameworks (MOFs). The distinct structure and features of BPMOs and MOFs will be initially evaluated, as well as their use as delivery vehicles for anticancer drug delivery applications. Then, the themes for the development of each material will be utilized to illustrate their drug delivery performance. Finally, the current obstacles and potential for future development as efficient drug delivery systems will be thoroughly reviewed.

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Section: Mofs Drug Delivery Performancementioning

confidence: 99%

Trend in biodegradable porous nanomaterials for anticancer drug delivery

Đoàn

2023

WIREs Nanomed Nanobiotechnol

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“…Applied very simple and generally, this hypothesis means that HP molecules are bigger than MSN/MOF pores. However, there is a growing mass of evidence in drug delivery area that doxorubicin drug with higher molecular dimensions in compassion with HP can be successfully loaded in MSNs and MOFs nanoparticles [ 15 , 16 , 49 , 50 , 51 , 52 , 53 , 54 ].…”

Section: Resultsmentioning

confidence: 99%

Hybrid Nanoparticles for Haloperidol Encapsulation: Quid Est Optimum?

et al. 2021

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The choice of drug delivery carrier is of paramount importance for the fate of a drug in a human body. In this study, we have prepared the hybrid nanoparticles composed of FDA-approved Eudragit L100-55 copolymer and polymeric surfactant Brij98 to load haloperidol—an antipsychotic hydrophobic drug used to treat schizophrenia and many other disorders. This platform shows good drug-loading efficiency and stability in comparison to the widely applied platforms of mesoporous silica (MSN) and a metal–organic framework (MOF). ZIF8, a biocompatible MOF, failed to encapsulate haloperidol, whereas MSN only showed limited encapsulation ability. Isothermal titration calorimetry showed that haloperidol has low binding with the surface of ZIF8 and MSN in comparison to Eudragit L100-55/Brij98, thus elucidating the striking difference in haloperidol loading. With further optimization, the haloperidol loading efficiency could reach up to 40% in the hybrid Eudragit L100-55/Brij98 nanoparticles with high stability over several months. Differential scanning calorimetry studies indicate that the encapsulated haloperidol stays in an amorphous state inside the Eudragit L100-55/Brij98 nanoparticles. Using a catalepsy and open field animal tests, we proved the prolongation of haloperidol release in vivo, resulting in later onset of action compared to the free drug.

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“…75 In addition, various physicochemical methods, such as ultrasound, can be used to increase the release in gastric juices. 76…”

Section: In Vitro Release Profiles Of Doxmentioning

confidence: 99%

Synthesis and activation of pH-sensitive metal–organic framework Sr(BDC)_∞ for oral drug delivery

Vodyashkin,

Sergorodceva,

Kezimana

et al. 2024

Dalton Trans.

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pH and ultrasound dual-responsive drug delivery system based on PEG–folate-functionalized Iron-based metal–organic framework for targeted doxorubicin delivery

Cited by 33 publications

References 41 publications

Trend in biodegradable porous nanomaterials for anticancer drug delivery

Trend in biodegradable porous nanomaterials for anticancer drug delivery

Hybrid Nanoparticles for Haloperidol Encapsulation: Quid Est Optimum?

Synthesis and activation of pH-sensitive metal–organic framework Sr(BDC)_∞ for oral drug delivery

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pH and ultrasound dual-responsive drug delivery system based on PEG–folate-functionalized Iron-based metal–organic framework for targeted doxorubicin delivery

Cited by 33 publications

References 41 publications

Trend in biodegradable porous nanomaterials for anticancer drug delivery

Trend in biodegradable porous nanomaterials for anticancer drug delivery

Hybrid Nanoparticles for Haloperidol Encapsulation: Quid Est Optimum?

Synthesis and activation of pH-sensitive metal–organic framework Sr(BDC)∞ for oral drug delivery

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Synthesis and activation of pH-sensitive metal–organic framework Sr(BDC)_∞ for oral drug delivery