Trend in biodegradable porous nanomaterials for anticancer drug delivery

Abstract

In recent years, biodegradable nanomaterials have exhibited remarkable promise for drug administration to tumors due to their high drug-loading capacity, biocompatibility, biodegradability, and clearance. This review will discuss and summarize the trends in utilizing biodegradable nanomaterials for anticancer drug delivery, including biodegradable periodic mesoporous organosilicas (BPMOs) and metal-organic frameworks (MOFs). The distinct structure and features of BPMOs and MOFs will be initially evaluated, as well as their use as delivery vehicles for anticancer drug delivery applications. Then, the themes for the development of each material will be utilized to illustrate their drug delivery performance. Finally, the current obstacles and potential for future development as efficient drug delivery systems will be thoroughly reviewed.

Microwave‐Assisted Synthesis of Porous Biomolecule‐Incorporated Metal‐Organic Frameworks as Efficient Nanocarriers for Anti‐Cancer Drugs

“…The particle size was approximately 200 � 15 nm, which is ideal for intravenous administration in in vivo applications as tumor sites can be passively targeted owing to the enhanced permeability and retention effect. [51][52][53] The aforementioned characterization results confirm the successful synthesis of the nanoscale b-MOF.…”

“…Notably, the image demonstrated the that material comprised consistent and homogeneous polyhedral particles, confirming the advantages of the MW method in synthesizing the material. The particle size was approximately 200±15 nm, which is ideal for intravenous administration in in vivo applications as tumor sites can be passively targeted owing to the enhanced permeability and retention effect [51–53] . The aforementioned characterization results confirm the successful synthesis of the nanoscale b‐MOF.…”

Integrating the amino-functionalized MOF-5 film with the silver nanoparticle substrate for a high SERS enhancement effect and long-term stability

“…12–15 Because of their remarkable porosity performance and huge specific surface area, MOFs have been widely used in separation, 16 catalysis, 17 and other applications since their discovery. 18,19 MOFs and SERS technology combination have significantly increased the detection limit and response time of typical SERS substrates. 20,21 MOF-coated Ag NPs may retain high SERS activity in biological analyses, improving the detection efficiency of SERS sensors.…”