2010
DOI: 10.1590/s1678-77572010000400002
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pH-cycling models for in vitro evaluation of the efficacy of fluoridated dentifrices for caries control: strengths and limitations

Abstract: Despite a plethora of in situ studies and clinical trials evaluating the efficacy of fluoridated dentifrices on caries control, in vitro pH cycling models are still broadly used because they mimic the dynamics of mineral loss and gain involved in caries formation. This paper critically reviews the current literature on existing pH-cycling models for the in vitro evaluation of the efficacy of fluoridated dentifrices for caries control, focusing on their strengths and limitations. A search was undertaken in th… Show more

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Cited by 168 publications
(178 citation statements)
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“…25 However, this in vitro protocol has important limitations, as it is not able to completely simulate the complex intraoral conditions leading to caries development such as bacterial biofilms and saliva, nor is it able to simulate clearance of the products from the oral cavity. 26 These limitations should be kept in mind when evaluating the results. Nonetheless, previous in vitro investigations of an experimental glass ionomer cement that contained BAG found the bonding agent inhibited growth of cariogenic bacteria.…”
Section: Discussionmentioning
confidence: 99%
“…25 However, this in vitro protocol has important limitations, as it is not able to completely simulate the complex intraoral conditions leading to caries development such as bacterial biofilms and saliva, nor is it able to simulate clearance of the products from the oral cavity. 26 These limitations should be kept in mind when evaluating the results. Nonetheless, previous in vitro investigations of an experimental glass ionomer cement that contained BAG found the bonding agent inhibited growth of cariogenic bacteria.…”
Section: Discussionmentioning
confidence: 99%
“…The use of a pHcycling method for inducing artificial caries lesions in human teeth is a good and reliable choice for simulating a carious lesion when compared with other methods, since the hardness values obtained with this cycling model are similar to those obtained from natural caries lesions 9 . Moreover, among in vitro protocols, this type of pH-cycling involves the combinations of demineralization and remineralization 21 , as the development of caries lesions represents the imbalance in the cycle of demineralization and remineralization 22 .…”
Section: Discussionmentioning
confidence: 99%
“…Every day, in our mouth, a dental substrates as enamel, dentin and cement are exposed to two processesdemineralization and reminerazation. It is related to the influence of fluoridated dentifrices on hard dental tissues [21]. Generally, in vitro pH-cycling models can be classified into models: -progression -remineralizing -reversal -remineralizing.…”
Section: Ph-cycling Modelmentioning
confidence: 99%
“…Substrates with artifical caries lesion can also be employed to measure the further demineralization (or remineralization) in demineralizing (or remineralizing) models [21].…”
Section: Ph-cycling Modelmentioning
confidence: 99%
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