pH-Responsive charge switchable PEGylated ε-poly-l-lysine polymeric nanoparticles-assisted combination therapy for improving breast cancer treatment

Guo, Zhihao; Sui, Junhui; Ma, Mengcheng; Hu, Jianshe; Sun, Yong; Yang, Liqun; Fan, Yujiang; Zhang, Xingdong

doi:10.1016/j.jconrel.2020.07.030

Cited by 89 publications

(37 citation statements)

References 53 publications

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“…As a result of confirming the antitumor effect in vivo, the tumor was more suppressed in the group treated with DOX and LAP nanoparticles compared to the group treated with only free DOX, free LAP, and DOX nanoparticles. In addition, it was confirmed that tumor volume in the DMMA-P-DOX/LAP nanoparticle group decreased more rapidly than that in the DMMA-P-DOX nanoparticle group, and the tumor was completely removed after chemotherapy [29].…”

Section: Release Of Co-loaded Drugs Through Ph Controlmentioning

confidence: 81%

“…Nanoparticles can accumulate in tumors through the EPR effect, but inefficient intracellular release results in inefficient treatment [46][47][48][49]. To solve this problem, Guo et al studied positively charged polymer nanoparticles to improve drug bioavailability through strong adsorption of negatively charged cell membranes and cationic polymer nanoparticles [29]. The surface of cationic nanoparticles is usually decorated with amino-rich functional groups.…”

Section: Release Of Co-loaded Drugs Through Ph Controlmentioning

confidence: 99%

“…The surface of cationic nanoparticles is usually decorated with amino-rich functional groups. One example is ε-poly-l-lysine (EPLYS), a naturally biodegradable homopoly(amino acid), which demonstrated no cytotoxicity with the resultant nanoparticles [29].…”

Section: Release Of Co-loaded Drugs Through Ph Controlmentioning

confidence: 99%

“…Through these processes, DOX and LAP were simultaneously released. The DMMA-P-DOX/LAP nanoparticle showed that, following intravenous injection, nanoparticles accumulated in the tumor tissue through the EPR effect, and the surface charge reversed from negative to positive, enhancing tumor cell internalization [29,63]. As a result, the low pH of the cells caused the cleavage of residual amino groups, thus rapidly breaking down nanoparticles.…”

Section: Release Of Co-loaded Drugs Through Ph Controlmentioning

confidence: 99%

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Recent Advances and Challenges in Controlling the Spatiotemporal Release of Combinatorial Anticancer Drugs from Nanoparticles

et al. 2020

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To overcome cancer, various chemotherapeutic studies are in progress; among these, studies on nano-formulated combinatorial drugs (NFCDs) are being actively pursued. NFCDs function via a fusion technology that includes a drug delivery system using nanoparticles as a carrier and a combinatorial drug therapy using two or more drugs. It not only includes the advantages of these two technologies, such as ensuring stability of drugs, selectively transporting drugs to cancer cells, and synergistic effects of two or more drugs, but also has the additional benefit of enabling the spatiotemporal and controlled release of drugs. This spatial and temporal drug release from NFCDs depends on the application of nanotechnology and the composition of the combination drug. In this review, recent advances and challenges in the control of spatiotemporal drug release from NFCDs are provided. To this end, the types of combinatorial drug release for various NFCDs are classified in terms of time and space, and the detailed programming techniques used for this are described. In addition, the advantages of the time and space differences in drug release in terms of anticancer efficacy are introduced in depth.

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Section: Release Of Co-loaded Drugs Through Ph Controlmentioning

confidence: 81%

Section: Release Of Co-loaded Drugs Through Ph Controlmentioning

confidence: 99%

Section: Release Of Co-loaded Drugs Through Ph Controlmentioning

confidence: 99%

Section: Release Of Co-loaded Drugs Through Ph Controlmentioning

confidence: 99%

See 2 more Smart Citations

Recent Advances and Challenges in Controlling the Spatiotemporal Release of Combinatorial Anticancer Drugs from Nanoparticles

et al. 2020

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“…PPT prodrug designed and self-assembly (Lv et al, 2014;Luan et al, 2019;Xu et al, 2020). The polyamine acid chain can be decomposed by enzymatic hydrolysis of the peptide bond, and the degradation product can be applied to the life cycle of the organism (Guo et al, 2020).…”

Section: Resultsmentioning

confidence: 99%

pH and ROS sequentially responsive podophyllotoxin prodrug micelles with surface charge-switchable and self-amplification drug release for combating multidrug resistance cancer

Wang

Zhang

et al. 2021

Drug Delivery

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Multidrug resistance (MDR) is one of the main reasons for tumor chemotherapy failure. Podophyllotoxin (PPT) has been reported that can suppress MDR cancer cell growth; however, effective delivery of PPT to MDR cancer cells is challenged by cascaded bio-barriers. To effectively deliver PPT to MDR cancer cells, a PPT polymeric prodrug micelle (PCDMA) with the charge-conversion capability and self-acceleration drug release function are fabricated, which is composed of a pH and reactive oxygen species (ROS) sequentially responsive PPT-polymeric prodrug and an ROS generation agent, cucurbitacin B (CuB). After reach to tumor tissue, the surface charge of PCDMA could rapidly reverse to positive in the tumor extracellular environment to promote cellular uptake. Subsequently, the PCDMA could be degraded to release PPT and CuB in response to an intracellular high ROS condition. The released CuB is competent for generating ROS, which in turn accelerates the release of PPT and CuB. Eventually, the released PPT could kill MDR cancer cells. The in vitro and in vivo studies demonstrated that PCDMA was effectively internalized by cancer cells and produces massive ROS intracellular, rapid release drug, and effectively overcame MDR compared with the control cells, due to the tumor-specific weakly acidic and ROS-rich environment. Our results suggest that the pH/ROS dual-responsive PCDMA micelles with surface charge-reversal and self-amplifying ROS-response drug release provide an excellent platform for potential MDR cancer treatment.

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Design of Stimuli‐Responsive Peptides and Proteins

Yang

Gerstweiler

et al. 2022

Adv Funct Materials

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Stimuli‐responsive peptides and proteins are an exciting class of smart biomaterials for various applications and have received significant attention over the past decades. A wide variety of stimuli such as temperature, pH, ions, enzymes, magnetic field, redox, etc., are explored. This article provides a review of five intensively studied types of stimuli‐responsive peptides and proteins, their design principles and applications, including temperature‐, pH‐, light‐, metal ion‐, and enzyme‐responsive with an emphasis on the key design concepts and switch function. Moreover, typical examples of their applications are discussed to provide a better understanding of the design concept and underlying methodology. This review will facilitate and inspire future innovation toward new peptide‐ and protein‐based materials and their diverse applications.

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pH-Responsive charge switchable PEGylated ε-poly-l-lysine polymeric nanoparticles-assisted combination therapy for improving breast cancer treatment

Cited by 89 publications

References 53 publications

Recent Advances and Challenges in Controlling the Spatiotemporal Release of Combinatorial Anticancer Drugs from Nanoparticles

Recent Advances and Challenges in Controlling the Spatiotemporal Release of Combinatorial Anticancer Drugs from Nanoparticles

pH and ROS sequentially responsive podophyllotoxin prodrug micelles with surface charge-switchable and self-amplification drug release for combating multidrug resistance cancer

Design of Stimuli‐Responsive Peptides and Proteins

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