pH responsive controlled release of anti-cancer hydrophobic drugs from sodium alginate and hydroxyapatite bi-coated iron oxide nanoparticles

Manatunga, Danushika C.; Silva, Rohini M. de; Silva, K.M. Nalin de; Silva, Nuwan De; Bhandari, Shiva; Yap, Yoke Khin; Costha, N. Pabakara

doi:10.1016/j.ejpb.2017.03.014

Cited by 102 publications

(54 citation statements)

References 57 publications

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“…[30][31][32] A novel drug carrier composed of sodium alginate, hydroxyapatite bilayer-coated iron oxide nanoparticle composite (IONP/HAp-NaAlg) was synthetized via the co-precipitation approach and used to delivery CUR over 7 days. 33 CUR encapsulated in polymeric nanoparticles showed higher solubility and enhanced bioavailability. 34 CUR was encapsulated into bovine serum albumin nanoparticles by co-precipitation method and showed higher cytotoxicity on A549 cells, HepG2 cells and RAW264.7 cells compared with the free CUR at the same drug concentration.…”

Section: Introductionmentioning

confidence: 99%

Liposomal curcumin and its application in cancer

Feng¹,

Wei²,

Lee³

et al. 2017

IJN

314

208

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Curcumin (CUR) is a yellow polyphenolic compound derived from the plant turmeric. It is widely used to treat many types of diseases, including cancers such as those of lung, cervices, prostate, breast, bone and liver. However, its effectiveness has been limited due to poor aqueous solubility, low bioavailability and rapid metabolism and systemic elimination. To solve these problems, researchers have tried to explore novel drug delivery systems such as liposomes, solid dispersion, microemulsion, micelles, nanogels and dendrimers. Among these, liposomes have been the most extensively studied. Liposomal CUR formulation has greater growth inhibitory and pro-apoptotic effects on cancer cells. This review mainly focuses on the preparation of liposomes containing CUR and its use in cancer therapy.

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Section: Introductionmentioning

confidence: 99%

Liposomal curcumin and its application in cancer

Feng¹,

Wei²,

Lee³

et al. 2017

IJN

314

208

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“…However, there is a great potential with the limited number of scientists who are actively associated with research in nano-drug carriers, antibacterial agents, and bone prostheses. These include development of bone prostheses (Rajapakse et al, 2016), drug encapsulation, for example, Vitamin C (Samantha Dissanayake et al, 2015), targeted cancer treatment (Katuwavila et al, 2016a;Weerasuriya et al, 2017;Nwokwu et al, 2017;Manatunga et al, 2017;Manatunga et al, 2018a), and developing antimicrobial agents (Peiris et al, 2017;Rathnayake et al, 2018). Rajapakse et al have actively engaged in nano hydroxyapatite-based biomaterials ( Fig.…”

Section: State Of Nanomedicine Research In Sri Lankamentioning

confidence: 99%

“…In addition, in vitro studies on successful biocompatible nanocarriers with magnetic targeting properties ( Fig. 2) have been well explored for many naturally available anticancer agents (Manatunga et al, 2017;Manatunga et al, 2018a) towards breast and liver cancer cells.…”

Section: State Of Nanomedicine Research In Sri Lankamentioning

confidence: 99%

“…The study carried out byManatunga et al (2017) involved the development of curcumin and 6-gingerol loaded sodium alginate and hydroxyapatite (HAp) bi-coated iron oxide nanoparticles for the purpose of pH responsive controlled drug release to treat cancer (reprinted from European Journal of Pharmaceutics and Biopharmaceutics, 117, Manatunga, D.C. et al, pH responsive controlled release of anti-cancer hydrophobic drugs from sodium alginate and hydroxyapatite bi-coated iron oxide nanoparticles, 29-38, Copyright (2018), with permission from Elsevier). 1 CERTKiD -Centre for Education, Research and Training on Kidney Diseaseshttps://www.pressreader.com/sri-lanka/sunday-timessri-lanka/20170312/283940292478123 (Accessed on 07/03/2018).…”

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confidence: 99%

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The state of nanomedicine in Sri Lanka: challenges and opportunities

Manatunga

Silva

2018

J of Interdiscip Nanomed

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Nanomedicine is rapidly expanding in the world due to its potential impact in alleviating various critical problems related to health. In this short review, we highlight the developments in nanomedicine in Sri Lanka through the work carried out by various scientists within the country. Potential challenges in the field and obstacles for conversion to clinical products will also be discussed. Even though there are limited contributions in relation to nano-drug carriers, antibacterial agents, and bone prostheses, the research focused on vaccine development, diagnosis, and imaging tools, and high-throughput screening platforms have not been developed. The main emphasis has been on therapeutic applications and anticancer drug delivery. Many hybrid biocompatible materials have been developed for drug delivery applications; however, work has been limited to in vitro studies due to various reasons. These findings can be extended to in vivo studies by strengthening the collaboration between nanotechnologists and health-related scientists, whose contribution at the clinical stages is paramount. Because of the slow pace of infrastructure development and related policies for clinical trials, many discoveries are terminated at the publication stage. Therefore, product development and commercialization are very challenging in the Sri Lankan context. The attraction of venture capitalists, investors, and government commitment represent current challenges for the product development and implementation of nanomedicine applications within the country.

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“…20,21 Therefore, fluorescent CQDs show great potential in the fields of photocatalysis, 22 biological imaging, 23 and drug delivery. 24 Sodium alginate is a naturally occurring linear polymer with good biocompatibility and stability, [25][26][27] which is widely used in the food industry, 28 tissue engineering medical field, 29 wound treatment, 30 drug release field, 31,32 etc. The moderately oxidized sodium alginate can form a C═N bond with a group such as an amino group due to the introduction of an aldehyde group, thus becoming a relatively friendly crosslinker.…”

Section: Introductionmentioning

confidence: 99%

pH‐sensitive carbon quantum dots−doxorubicin nanoparticles for tumor cellular targeted drug delivery

Bao

Hollywood

Wang

et al. 2019

Polymers for Advanced Techs

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A kind of pH‐responsive carbon quantum dots−doxorubicin nanoparticles drug delivery platform (D‐Biotin/DOX‐loaded mPEG‐OAL/N‐CQDs) was designed and synthesized. The system consists of fluorescent carbon dots as cross‐linkers, and D‐Biotin worked as targeting groups, which made the system have a pH correspondence, doxorubicin hydrochloride (DOX) as the target drug, oxidized sodium alginate (OAL) as carrier materials. Ultraviolet (UV)‐Vis spectrum showed that the drug‐loading rate of DOX is 10.5%, and the drug release in vitro suggested that the system had a pH response and tumor cellular targeted, the drug release rate is 65.6% at the value of pH is 5.0, which is much higher than that at the value of pH is 7.4. The cytotoxicity test and laser confocal fluorescence imaging showed that the synthesized drug delivery system has high cytotoxicity to cancer cells, and the drug‐loaded nanoparticles could enter the cells through endocytosis.

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pH responsive controlled release of anti-cancer hydrophobic drugs from sodium alginate and hydroxyapatite bi-coated iron oxide nanoparticles

Cited by 102 publications

References 57 publications

Liposomal curcumin and its application in cancer

Liposomal curcumin and its application in cancer

The state of nanomedicine in Sri Lanka: challenges and opportunities

pH‐sensitive carbon quantum dots−doxorubicin nanoparticles for tumor cellular targeted drug delivery

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