pH-responsive mesoporous ZSM-5 zeolites/chitosan core-shell nanodisks loaded with doxorubicin against osteosarcoma

Yang, Fan; Wen, Xi; Ke, Qinfei; Xie, Xuetao; Guo, Ya‐Jun

doi:10.1016/j.msec.2017.12.024

Cited by 50 publications

(26 citation statements)

References 72 publications

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“…Figure 4a,b illustrated the surface morphology of new CTS-ZMS adsorbent and after running 3 months adsorbed with ammonium nitrogen from the filter column at 1000 magnification, respectively. The surface of CTS-ZMS adsorbent was composed of cubic crystals with regular morphology, which conformed to the morphology of the zeolite NaA type [37]. According to the detection result of BET, the surface area, the average pore diameter and pore volume of CTS-ZMS were 20.782 m 2 /g, 3.56 nm and 0.097 cm 3 /g, respectively.…”

Section: Dynamic Adsorption Modelmentioning

confidence: 64%

“…When the solution was an acidic environment (Ph = 4.5), the column adsorption capacity was lower than Ph = 6.5, which was attributed to the positively charged amine groups (-NH 2 ) of chitosan that became protonated at acidic pH (-NH 3 + ). The -NH 3 + exerted repulsive forces to the approaching NH 4 + -N that hindered adsorption of the approaching ions onto the CTS-ZMS surface [37]. In an alkaline environment, the OH − and the ammonium nitrogen formed NH 3 , about 10% of NH 4 + was converted to NH 3 at basic pH [38].…”

Section: Effect Of Initial Ph Valuementioning

confidence: 99%

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Chitosan Modified Zeolite Molecular Sieve Particles as a Filter for Ammonium Nitrogen Removal from Water

Gao

Zhang

2020

IJMS

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Drinking water containing a high amount of ammonium-nitrogen (NH4+-N) is not effectively removed by conventional treatment processes and can cause eutrophication. In this research, a composite adsorbent based on chitosan crosslink with zeolite molecular sieve (CTS-ZMS) was prepared for NH4+-N removal through dynamic adsorption filter experiments. Effect of bed depth (30, 50 and 70 cm), flow rate (32, 49 and 65 mL/min), initial pH value (4.5, 6.5 and 8.5) and influent NH4+-N concentration (3, 5 and 7 mg/L) was examined by using a filter column packed with CTS-ZMS particles. The Thomas model was applied to study the breakthrough curves and adsorption capacity. The optimal process parameters of the aforementioned factors were obtained at bed depth of 70 cm, flow rate of 32 mL/min, pH of 6.5 and initial NH4+-N concentration of 7 mg/L. Scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS) and Fourier Transform Infrared Spectroscopy (FTIR) were investigated to analyze the structure and morphology of the CTS-ZMS adsorbents before and after 3 months running. The EDS and FTIR results showed Na+ and the active functional groups of -OH, -NH2 and -COO− on CTS-ZMS adsorbent particles reacted with ammonium nitrogen. The results of this study supported the use of CTS-ZMS to improve drinking water filtration processes by increasing ammonium nitrogen reductions.

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Section: Dynamic Adsorption Modelmentioning

confidence: 64%

Section: Effect Of Initial Ph Valuementioning

confidence: 99%

Chitosan Modified Zeolite Molecular Sieve Particles as a Filter for Ammonium Nitrogen Removal from Water

Gao

Zhang

2020

IJMS

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“…For the LaPO 4 /CS scaffolds and CS powders (Fig. 3 a, c), the bands at 1662, 1595 and 894 cm −1 corresponded to the amide-I vibration, N–H deformation vibration and N–H wagging vibration in amino groups, respectively [ 33 ]. The C-O stretching vibration bands were located at 1072/1034 cm −1 , and the bridge oxygen stretching vibration bands were located at 1152 cm −1 [ 34 ].…”

Section: Resultsmentioning

confidence: 99%

Lanthanum phosphate/chitosan scaffolds enhance cytocompatibility and osteogenic efficiency via the Wnt/β-catenin pathway

Zhao

Liu

et al. 2018

J Nanobiotechnol

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BackgroundFabrication of porous scaffolds with great biocompatibility and osteoinductivity to promote bone defect healing has attracted extensive attention.MethodsIn a previous study, novel lanthanum phosphate (LaPO4)/chitosan (CS) scaffolds were prepared by distributing 40- to 60-nm LaPO4 nanoparticles throughout plate-like CS films.ResultsInterconnected three dimensional (3D) macropores within the scaffolds increased the scaffold osteoconductivity, thereby promoting cell adhesion and bone tissue in-growth. The LaPO4/CS scaffolds showed no obvious toxicity and accelerated bone generation in a rat cranial defect model. Notably, the element La in the scaffolds was found to promote osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) through the Wnt/β-catenin signalling pathway and induced high expression of the osteogenesis-related genes alkaline phosphatase, osteocalcin and Collagen I (Col-I). Moreover, the LaPO4/CS scaffolds enhanced bone regeneration and collagen fibre deposition in rat critical-sized calvarial defect sites.ConclusionThe novel LaPO4/CS scaffolds provide an admirable and promising platform for the repair of bone defects.Electronic supplementary materialThe online version of this article (10.1186/s12951-018-0411-9) contains supplementary material, which is available to authorized users.

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“…The pH in the subcellular compartments decreases to 5.0-6.0 in endosomes and 4.0-5.0 in lysosomes 100. Through the introduction of acid-sensitive linkers, such as acetal, hydrazone, and glycerol ester groups, these pH-sensitive nanocarriers could store and stabilize antitumor drugs at physiological pH, but rapidly release the drugs at an acidic environment 100, 130, 131. In a recent study, mesoporous zinc hydroxyapatite (ZnHAP) decorated with pluronic block copolymer, F127, was synthesized and used as a carrier for drug delivery 132.…”

Section: Controlled Release Of Loaded Drugsmentioning

confidence: 99%

“…The drug release rate at PH 5.3 was much higher than PH 7.4 in both protein-free phosphate buffered saline (PBS) and protein-containing cell culture medium. Chitosan have been used to functionalize drug carriers, enabling the composite carriers to possess pH-responsive performances and show high drug release rate in the slightly acidic environment than in the neutral environment 131.…”

Section: Controlled Release Of Loaded Drugsmentioning

confidence: 99%

Recent advances of drug delivery nanocarriers in osteosarcoma treatment

Wang¹,

Hu²,

Qing³

et al. 2020

J. Cancer

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Osteosarcoma is the most common primary malignant bone tumor mainly occurred in children and adolescence, and chemotherapy is limited for the side effects and development of drug resistance. Advances in nanotechnology and knowledge of cancer biology have led to significant improvements in developing tumor-targeted drug delivery nanocarriers, and some have even entered clinically application. Delivery of chemotherapeutic agents by functionalized smart nanocarriers could protect the drugs from rapid clearance, prolong the circulating time, and increase the drug concentration at tumor sites, thus enhancing the therapeutic efficacy and reducing side effects. Various drug delivery nanocarriers have been designed and tested for osteosarcoma treatment, but most of them are still at experimental stage, and more further studies are needed before clinical application. In this present review, we briefly describe the types of commonly used nanocarriers in osteosarcoma treatment, and discuss the strategies for osteosarcoma-targeted delivery and controlled release of drugs. The application of nanoparticles in the management of metastatic osteosarcoma is also briefly discussed. The purpose of this article is to present an overview of recent progress of nanoscale drug delivery platforms in osteosarcoma, and inspire new ideas to develop more effective therapeutic options.

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pH-responsive mesoporous ZSM-5 zeolites/chitosan core-shell nanodisks loaded with doxorubicin against osteosarcoma

Cited by 50 publications

References 72 publications

Chitosan Modified Zeolite Molecular Sieve Particles as a Filter for Ammonium Nitrogen Removal from Water

Chitosan Modified Zeolite Molecular Sieve Particles as a Filter for Ammonium Nitrogen Removal from Water

Lanthanum phosphate/chitosan scaffolds enhance cytocompatibility and osteogenic efficiency via the Wnt/β-catenin pathway

Recent advances of drug delivery nanocarriers in osteosarcoma treatment

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