pH-responsive perylenediimide nanoparticles for cancer trimodality imaging and photothermal therapy

Zhang

2021

Polymer Composites

Ag nanoparticle filled thermoplastic polyurethane (AgNPs/TPU) composites are widely used in medical, energy, packaging, electronic devices, additive manufacturing and many other fields, where the service temperature fluctuates easily, making it necessary to study the temperature effect on the properties of composites. In this work, multifunctional AgNPs/TPU composites with different AgNP contents were prepared by a mixing and hot‐pressing method. The results show that the phase change property of TPU is not affected by the addition of AgNPs, but the thermal diffusivity is improved. As the content of AgNPs increases, the thermal conductivities of AgNPs/TPU composites increase significantly, whereas the temperature has an opposite effect. The results of elongation at break and tensile strength show a decreased trend with the increase in the AgNP content and a trend of first increasing and then decreasing with the increase in temperature. As the temperature increases, the tensile moduli of AgNPs/TPU composites decrease significantly. For the temperature higher than 50°C, the electrical percolation thresholds of composites decrease from 5.5 vol% to a lower content. The results prove that the temperature has a significant influence on the thermal, mechanical, and electrical properties of AgNPs/TPU composites.

“…Compared with the darker color of AgNPs/TPU composites, the photothermal effect on the lighter color of TPU would also decrease the heating rate. [ 26–29 ]…”

Section: Resultsmentioning

confidence: 99%

Temperature effect on thermal, mechanical, and electrical properties of Ag nanoparticle filled thermoplastic polyurethane composites

Zhang

2021

Polymer Composites

“…These pH‐responsive PDI NPs with simple synthesis procedures and high stability showed excellent multifunctional phototheranostic effect in cancer. [ 134 ] Li et al. developed a biodegradable PTT agent based on π‐conjugated oligomer NPs (F8‐PEG NPs) with D‐A structure, which showed excellent NIR absorption and high photothermal conversion efficiency (η ≈ 82%).…”

Section: Organic Npsmentioning

confidence: 99%

All‐in‐One Nanomedicine: Multifunctional Single‐Component Nanoparticles for Cancer Theranostics

Cai

et al. 2021

Small

The development of cancer diagnostic imaging and treatment is a major concern worldwide. By integrating imaging and therapy into one theranostic nanoplatform for simultaneously detecting tumors, evaluating the targeting ability and timely monitoring therapeutic responses provide more opportunities for precision medicine. Among various theranostic nanosystems, a series of single‐component nanoparticles (NPs) have been developed for “all‐in‐one” theranostics, which presents the unique properties of facile preparation, simple composition, defined structure, high reproducibility, and excellent biocompatibility. Specifically, utilizing single‐component NPs for both diagnostics and therapeutics can reduce the possible numerous untoward side effects and risks to the living body. In this review, the recent progress of multifunctional single‐component NPs in the applications of cancer theranostics is systematically summarized. Notably, the structure design, categories of NPs, targeted strategies, biomedical applications, potential barriers, challenges, and prospects for the future clinical practice of this rapidly growing field are discussed.

“…However, the single treatment mode and limited penetration depth of excitation light make current diagnosis and treatment efficiency of organic chromophores not satisfactory. Thus, designing multimodal imaging agents is highly needed, which will provide more specific and precise cancer information 89,90 . A new type of multimodel phototheranostic agent (PPDI‐NPs) incorporating piperazine ring at the bay regions of PDI was prepared to realize NIR absorption (Figure 8C).…”

Section: Imaging‐guided Cancer Therapymentioning

confidence: 99%

Functional organic dyes for health‐related applications

Cheng

Liu

et al. 2020

VIEW

Self Cite

Nowadays, photo-based diagnosis and treatment techniques have been the focus in health-related fields. Organic dyes with delicately designed structures and tunable optical properties were used for fluorescence and photoacoustic imaging as well as phototherapy including photodynamic and photothermal therapy. The theranostic agents exhibit better treatment efficacy with minimized invasiveness, which have shown great potential for disease treatment. To suit health-related application, regulating the photophysical properties of functional organic dyes and improving their biocompatibility is the prerequisite for designing efficient optical diagnostic reagents. This review summarizes recent advances in the design, fabrication, and applications of functional organic dye-based material in health-related fields. The design and preparation strategies of these dyes mainly include tuning the absorption, emission, photodynamic and photothermal properties of dyes through chemical modification of chromophore scaffold, obtaining water-soluble macromolecules through peripheral functional modification, constructing nanotheranostic reagents through self-assembly process or preparing fluorescent detection devices. Based on these materials, functional organic dyes have been used in a variety of cancer treatment methods for bacterial detection and antibacterial fields, in vitro and in vivo disease detection, as well as fluorescence/photoacoustic imaging-guided cancer therapy, which were summarized in this review. Finally, possible functionalization directions of organic dyes are also proposed to meet the needs of advanced health-related applications.