pH-Responsive wound dressings: advances and prospects

Abstract

This review focuses on the design strategies and advanced functions of pH-responsive wound dressings, and makes a systematic discussion of the challenges and future development trends in this field.

Ag+-Adsorbing Semiconducting Polymer Nanosponge for Smart Local Treatment of Wound Infection

“…During the process of wound healing, the injured site presents a weakly acidic environment with a pH range of 5.0–6.5. – Previous research has reported that carboxyl and aliphatic hydroxyl groups exhibit weak binding affinity toward Ag + , which is more favorable for its release in acidic environments. , In addition, PTT effect can also accelerate the release of Ag + . , To verify the responsive Ag + release kinetics of PDPP3T NPe@Ag + , the cumulative amount of Ag + release at different time points was monitored by ICP–MS. As shown in Figure a,b, PDPP3T NPe@Ag + showed relatively high Ag + release at pH 6.3 than that at pH 7.4.…”

pH-Responsive Wound Dressing Based on Biodegradable CuP Nanozymes for Treating Infected and Diabetic Wounds

“…During this period, bacteria in the wound site tend to secrete significant amounts of lactic acid and carbonic acid, rendering the wound's pH slightly acidic. 24,65 As time progresses, diabetic wounds transition into a state of persistent chronic inflammatory response, leading to the accumulation of pro-inflammatory alkaline cytokines within the wound area, resulting in an alkaline shift in the wound microenvironment. 65 Notably, the Alg/CuP hydrogel designed in this study exhibits versatility in addressing skin wounds within complex pH environments.…”

“…24,65 As time progresses, diabetic wounds transition into a state of persistent chronic inflammatory response, leading to the accumulation of pro-inflammatory alkaline cytokines within the wound area, resulting in an alkaline shift in the wound microenvironment. 65 Notably, the Alg/CuP hydrogel designed in this study exhibits versatility in addressing skin wounds within complex pH environments. For patients with early-stage diabetic wounds (where the primary need is rapid wound healing and infection control), Alg/CuP can demonstrate POD-like enzyme activity to swiftly eradicate bacteria in the wound area.…”

MXene and Xene: promising frontier beyond graphene in tissue engineering and regenerative medicine

“…Skin tissue engineering involves preparing artificial substitutes that replicate human skin, primarily driven by the crucial role of the skin as a protective barrier against various environmental threats. 143 This field employs advanced tissue engineering techniques to develop skin substitutes for use as sophisticated models in research and in applications such as wound healing. A key challenge is the ex vivo expansion of cells, while preserving their normal properties, for use in transplantation or in vitro studies.…”