pH-Sensitive Chitosan Hydrogel with Instant Gelation for Myocardial Regeneration

Alimirzaei, F; Vasheghani‐Farahani, Ebrahim; Ghiaseddin, Ali; Soleimani, Mansooreh; Pouri,; Najafi-Gharavi, Zeinab

doi:10.4172/2157-7552.1000212

Cited by 6 publications

(2 citation statements)

References 44 publications

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“…After reaching equilibrium, the swelling ratio is maintained at around 15% for all samples incubated in PBS with pH 6.0. For other hydrogels for the same application, reaching a swelling equilibrium might take 8 h for a gelatin methacrylate and oxidized dextran hydrogel or even 12 h for a chitosan-based hydrogel . On the one hand, to reach a faster equilibrium, this more rapid swelling observed on the samples containing LNFs or AuNPs@LNFs might allow a swifter release of components incorporated within these hydrogels ( e.g.…”

Section: Results and Discussionmentioning

confidence: 99%

“…For other hydrogels for the same application, reaching a swelling equilibrium might take 8 h for a gelatin methacrylate and oxidized dextran hydrogel 15 or even 12 h for a chitosan-based hydrogel. 65 On the one hand, to reach a faster equilibrium, this more rapid swelling observed on the samples containing LNFs or AuNPs@LNFs might allow a swifter release of components incorporated within these hydrogels (e.g., drugs or growth factors). 64 On the other hand, when incubated in PBS with pH 7.4, these hydrogels swell much faster, reaching around 32% (GHA-0LNFs hydrogel) and 27% swelling (hydrogels containing LNFs or AuNPs@LNFs) after 8 h of incubation.…”

Section: Antioxidant Activitymentioning

confidence: 99%

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Injectable Nanocomposite Hydrogels of Gelatin-Hyaluronic Acid Reinforced with Hybrid Lysozyme Nanofibrils-Gold Nanoparticles for the Regeneration of Damaged Myocardium

Carvalho

Bártolo

Pedro

et al. 2023

ACS Appl. Mater. Interfaces

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Biopolymeric injectable hydrogels are promising biomaterials for myocardial regeneration applications. Besides being biocompatible, they adjust themselves, perfectly fitting the surrounding tissue. However, due to their nature, biopolymeric hydrogels usually lack desirable functionalities, such as antioxidant activity and electrical conductivity, and in some cases, mechanical performance. Protein nanofibrils (NFs), such as lysozyme nanofibrils (LNFs), are proteic nanostructures with excellent mechanical performance and antioxidant activity, which can work as nanotemplates to produce metallic nanoparticles. Here, gold nanoparticles (AuNPs) were synthesized in situ in the presence of LNFs, and the obtained hybrid AuNPs@LNFs were incorporated into gelatin-hyaluronic acid (HA) hydrogels for myocardial regeneration applications. The resulting nanocomposite hydrogels showed improved rheological properties, mechanical resilience, antioxidant activity, and electrical conductivity, especially for the hydrogels containing AuNPs@LNFs. The swelling and bioresorbability ratios of these hydrogels are favorably adjusted at lower pH levels, which correspond to the ones in inflamed tissues. These improvements were observed while maintaining important properties, namely, injectability, biocompatibility, and the ability to release a model drug. Additionally, the presence of AuNPs allowed the hydrogels to be monitorable through computer tomography. This work demonstrates that LNFs and AuNPs@LNFs are excellent functional nanostructures to formulate injectable biopolymeric nanocomposite hydrogels for myocardial regeneration applications.

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Section: Results and Discussionmentioning

confidence: 99%