pH-sensitive core-shell electrospun nanofibers based on polyvinyl alcohol/polycaprolactone as a potential drug delivery system for the chemotherapy against cervical cancer

Yan, Eryun; Jiang, Jinyu; Yang, Xiaojing; Fan, Liquan; Wang, Yuwei; An, Qinglong; Zhang, Zuoyuan; Lu, Borong; Wang, Dianyu; Zhang, Deqing

doi:10.1016/j.jddst.2019.101455

Cited by 67 publications

(35 citation statements)

References 30 publications

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“…In another case, pH-responsive nanofibers were fabricated by the synthesis of poly(4-vinylbenzoic acid-co-(arvinylbenzyl) trimethylammonium chloride) via addition-fragmentation chain transfer (RAFT) polymerization [70]. Similarly, DOX-loaded pH-responsive core-shell nanofibers were fabricated via coaxial electrospinning, with PVA as the core and PCL as the shell layer, which showed sustained and pH-responsive release of DOX and held great potential for the application in cervical cancer treatment [71].…”

Section: Ph-responsive Electrospun Fibersmentioning

confidence: 99%

Functional Electrospun Fibers for Local Therapy of Cancer

2020

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Despite great efforts and advancement in the treatment of cancer, tumor recurrence and metastasis remain significant challenges and demand novel therapy strategies. Recently, advances in biomaterials and drug delivery systems have facilitated the development of the local therapy of cancer, among which electrospun nanofibrous scaffolds show great promise owing to their porous structure, relatively large surface area, high drug loading capacity, similarity with the native extracellular matrix, and possibility of the combination of various therapies. Here, we review this rapidly developing field of electrospun nanofibrous scaffolds as a drug delivery system for cancer local therapy, in particular addressing stimuli-responsive drug release, as well as its combination with stem cell and immune therapy. Challenges and future perspectives are also discussed.

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Section: Ph-responsive Electrospun Fibersmentioning

confidence: 99%

Functional Electrospun Fibers for Local Therapy of Cancer

2020

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“…ity [30], low toxicity [24,[31][32][33], good strength [34,35], and high water content [36][37][38]. Currently, the PVA-based materials are extensively utilized in the medical, industrial, and agricultural industries [39].…”

Section: Abstract a R T I C L E I N F O R M A T I O Nmentioning

confidence: 99%

A review of Polyvinyl alcohol / Carboxiy methyl cellulose (PVA/CMC) composites for various applications

khoramabadi

Arefian

Hojjati

et al. 2020

jcc

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Polyvinyl alcohol/carboxymethyl cellulose (PVA/CMC) composites have attracted considerable attention due to the synergic relation between the two polymers and developing novel blends with improved properties. On one hand, PVA is a versatile polymer with higher mechanical properties compared to CMC. On the other hand, CMC has high biodegradability and biocompatibility, while suffering from poor mechanical properties. Therefore, the blending of the two polymers can help to benefit from the individual component properties. This paper has reviewed the properties and potential applications (e.g. drug delivery, food packaging, and agriculture) of the PVA/ CMC composites.

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“…Therefore, coaxial electrospinning is considered one of the most significant breakthroughs in the field of drug-sustained release [ 81 , 82 ]. Yan et al [ 83 ] successfully prepared PH-sensitive PVA/polycaprolactone (PCL) core–shell nanofibers using coaxial electrospinning technology, achieving sustained PH-responsive release of the anticancer drug doxorubicin (DOX).…”

Section: Electrospinning Technologymentioning

confidence: 99%

Electrospun Medicated Nanofibers for Wound Healing: Review

et al. 2021

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With the increasing demand for wound care and treatment worldwide, traditional dressings have been unable to meet the needs of the existing market due to their limited antibacterial properties and other defects. Electrospinning technology has attracted more and more researchers’ attention as a simple and versatile manufacturing method. The electrospun nanofiber membrane has a unique structure and biological function similar to the extracellular matrix (ECM), and is considered an advanced wound dressing. They have significant potential in encapsulating and delivering active substances that promote wound healing. This article first discusses the common types of wound dressing, and then summarizes the development of electrospun fiber preparation technology. Finally, the polymers and common biologically active substances used in electrospinning wound dressings are summarized, and portable electrospinning equipment is also discussed. Additionally, future research needs are put forward.

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pH-sensitive core-shell electrospun nanofibers based on polyvinyl alcohol/polycaprolactone as a potential drug delivery system for the chemotherapy against cervical cancer

Cited by 67 publications

References 30 publications

Functional Electrospun Fibers for Local Therapy of Cancer

Functional Electrospun Fibers for Local Therapy of Cancer

A review of Polyvinyl alcohol / Carboxiy methyl cellulose (PVA/CMC) composites for various applications

Electrospun Medicated Nanofibers for Wound Healing: Review

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