pH-sensitive interpenetrating network hydrogels based on chitosan derivatives and alginate for oral drug delivery

Yang, Junhong; Chen, Jie; Dan, Pan; Wan, Ying; Wang, Zheng

doi:10.1016/j.carbpol.2012.09.036

Cited by 154 publications

(68 citation statements)

References 30 publications

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“…Due to the presence of chemical or physical crosslinking, they can make conventional change of volume in response with different pH values, namely swelling or deswelling in solvents of different pH values (Gupta et al, 2002;Kim & Peppas, 2003;Ranjha et al, 2008;Nguyen et al, 2009;Wang et al, 2010a). Therefore, they have more potential applications in drug delivery systems, especially oral drug delivery systems owning to the particularity of the physiological structure of the digestive tract (the pH in the upper gastrointestinal tract is relatively low, while in the lower gastrointestinal tract is higher) (Peppas et al, 2004;Sande, 2005;Guo & Gao, 2007;Wong, 2010;Chaturvedi et al, 2012;Yang et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Assessment of the drug loading, in vitro and in vivo release behavior of novel pH-sensitive hydrogel

Dong

You

et al. 2014

Drug Delivery

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, then mixing them together to prepare hydrogel through the heat-initiated free radical polymerization method. Differential scanning calorimetry and X-ray diffraction methods were used to verify whether dexamethasone was loaded into hydrogels. In vitro drug release behavior and in vivo pharmacokinetic study were also investigated in detail.Results: Dexamethasone was successfully loaded into hydrogel, and its loading capacity was improved (5 mg/g). Both the in vitro release study and the in vivo pharmacokinetic study showed the good colon-targeting character of the pH-sensitive P(LE-IA-MEG) hydrogel (T max ¼ 1.0 h, C max ¼ 2.16 mg/ml of dexamethasone; T max ¼ 3.9 h, C max ¼ 0.43 mg/ml of dexamethasone hydrogel). Discussion: Dexamethasone could be targeted to the colon site by P(LE-IA-MEG) hydrogel, thereby improving its therapeutic effect and reduce its side effects. Conclusion: P(LE-IA-MEG) hydrogel might have great potential application in colon-targeted drug delivery systems. KeywordsDexamethasone, drug-loading, in vitro drug release study, in vivo pharmacokinetic study, pH-sensitive History

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Section: Introductionmentioning

confidence: 99%

Assessment of the drug loading, in vitro and in vivo release behavior of novel pH-sensitive hydrogel

Dong

You

et al. 2014

Drug Delivery

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“…In Fig.13, it was observed that the cumulative release of BSA were lower than 10 % for the gel beads crosslinked by 0.10 g β-GP and 0.12 g β-GP. The results were greatly improved compared to the pure SA/Ca 2+ beads and other composite SA/Ca 2+ system reported before [35]. Due to the dual physical crosslinking methods within the two nature polymers, the phenomenon of burst release in SA/Ca 2+ system was effectively inhibited.…”

Section: In Vitro Release Of Bsamentioning

confidence: 68%

Alginate/carboxymethyl chitosan composite gel beads for oral drug delivery

Peng

et al. 2016

J Polym Res

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This paper reports the synthesis of pH-sensitive gel beads derived from alginate (SA) and carboxymethyl chitosan (CMCS) for drug delivery. The composite SA/CMCS gel beads were prepared by dual ionic gelation: one ionic gelation between SA and Ca 2+ and another one between CMCS and β-Sodium glycerophosphate (β-GP). The structure properties of hydrogel beads were characterized by SEM, IR and TG technique. The influence of the polymer composition and crosslinkers on the gel swelling property was investigated. When the concentration of CMCS and SA were 3 % and the volume ratio was 1:2, the swelling rate of gel beads crosslinked by β-GP and CaCl 2 solution can increase up to 31.2 and the swelling time can reach 10.5 h. In the drug release study, bovine serum albumin (BSA) was chosen as model drugs. The results indicated that BSA released slowly from the gel beads at pH 1.2 and the release ratio was about 10 %. At pH 7.4, the amounts of BSA released increased significantly as compared to those released at pH 1.2 and the total release time was extended to 11 h. The composite gel system demonstrates sustained release profile and pH sensitivity, which can be considered as good candidates for oral drug delivery systems.

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“…gel beads, which could be contribute to the dual cross-linking effect leading to the compact structure in the gel network. As is well known, many drugs were very sensitive to the harsh acidic condition, hence, the lower swelling ratio of the gel beads in acidic condition was very important feature for the drug delivery application to protect the drugs in case of being destroyed [30].…”

Section: Effect Osa On Gel Swelling Propertiesmentioning

confidence: 99%

Preparation and characterization of composite hydrogel beads based on sodium alginate

Chen

Dong

et al. 2015

Polym. Bull.

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In this report, novel biopolymer hydrogels composed of sodium alginate (SA) and the oxidized sodium alginate (OSA) with an interpenetrating polymer network (IPN) structure were prepared by a combination of chemical and ionic cross-linking approaches. By using SA as the main raw material, OSA was obtained using sodium periodate. The gelation process of the IPN hydrogels was the formation of dual network: one gelatin network cross-linked by OSA with dihydrazide and another SA network cross-linked by Ca 2? . The factors which affect its swelling properties were discussed. The best swelling ratio of the beads was 2300, and the swelling property was greatly affected by pH and preparation condition. The stability and swelling behavior of OSA/SA gel beads were better improved than the pure SA/Ca 2? system. The OSA/SA hydrogel beads with the pH sensitivity and stability will be a good candidate for site-specific controlled drug release carrier.

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pH-sensitive interpenetrating network hydrogels based on chitosan derivatives and alginate for oral drug delivery

Cited by 154 publications

References 30 publications

Assessment of the drug loading, in vitro and in vivo release behavior of novel pH-sensitive hydrogel

Assessment of the drug loading, in vitro and in vivo release behavior of novel pH-sensitive hydrogel

Alginate/carboxymethyl chitosan composite gel beads for oral drug delivery

Preparation and characterization of composite hydrogel beads based on sodium alginate

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