pH-Sensitive Liposomes as Adjuvants for Peptide Antigens

Elastic vesicles as topical/transdermal drug delivery systems

“…One possibility for increasing the penetration of drugs is the use of vesicular systems such as liposomes. Due to their biocompatibility and capability of incorporating both hydrophilic and lipophilic drugs, liposomes have been investigated as parenteral drug and antigen carrier systems and more recently as TT drug delivery systems [9–18]. Mezei and Gulasekharam [5, 19] first reported their potential use of liposomes in topical applications for skin.…”

Particulate Systems as Adjuvants and Carriers for Peptide and Protein Antigens

“…One approach involves the use of pH-sensitive lipids such as phosphatidyl-β-oleoyl-γ-palmitoyl ethanolamine (POPE). The slightly acidic pH of early endosomes can trigger the destabilization of the liposomal membrane containing these lipids, resulting in their fusion with the endosomal membrane and the release of peptide [80] and protein antigens [81]. These liposomes have been shown to promote CTL responses both in vitro and in vivo [82].…”

Liposomes

“…One possibility for increasing the penetration of drugs is the use of vesicular systems such as liposomes. Due to their biocompatibility and capability of incorporating both hydrophilic and lipophilic drugs, liposomes have been investigated as parenteral drug and antigen carrier systems and more recently as TT drug delivery systems [9][10][11][12][13][14][15][16][17][18]. Mezei and Gulasekharam [5,19] first reported their potential use of liposomes in topical applications for skin.…”