pH-Sensitive nanoparticles based on amphiphilic imidazole/cholesterol modified hydroxyethyl starch for tumor chemotherapy

Xu, Zhilang; Yang, Die; Long, Tao; Long, Yuan; Qiu, Shi; Li, Defu; Mu, Changdao; Ge, Liming

doi:10.1016/j.carbpol.2021.118827

Cited by 38 publications

(19 citation statements)

References 66 publications

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“…PEG modification on the surface of nanocarriers can effectively reduce the adsorption of nonspecific proteins, prolong the circulation time, and increase the biocompatibility of the drug carriers in vivo , which is also known as the “invisibility” effect of PEG . Moreover, the hemolysis rate of blood contacting biomaterials must be low, so as to protect the life and health of patients from higher risk . Hemocompatibility of Cur@CPC NMs was evaluated in terms of both anti-protein-adsorption performance and hemolysis rate.…”

Section: Resultsmentioning

confidence: 99%

Multifunctional β-Cyclodextrin–Poly(ethylene glycol)–Cholesterol Nanomicelle for Anticancer Drug Delivery

Yang

et al. 2022

ACS Appl. Bio Mater.

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Nanoparticle drug delivery systems have drawn considerable attention worldwide due to their unique characteristics and advantages in anticancer drug delivery. Herein, the curcumin (Cur) loaded nanomicelles with two-stage drug release behavior were developed. β-Cyclodextrin (β-CD) and cholesterol were conjugated onto both ends of the poly(ethylene glycol) (PEG) chain to obtain an amphiphilic β-CD-PEG-Chol. The Cur was loaded into the cavities of β-CD and nanomicelle when the β-CD-PEG-Chol self-assembled to the Cur@β-CD-PEG-Chol nanomicelles (Cur@CPC NMs). These Cur@CPC NMs are spherical particles with a particle size of 120.9 nm. The Cur drug loading capacity of Cur@CPC NMs are 61.6 ± 6.9 mg/g. The release behavior of Cur from Cur@CPC NMs conformed to a two-stage mode of "burst-release followed by sustained-release". The prepared Cur@CPC NMs possess high storage stability and excellent hemocompatibility. Moreover, these Cur@CPC NMs exhibit satisfactory antioxidant activity and anticancer activity, resulting in significant reduction in intracellular H 2 O 2 -induced ROS and a nearly 50% lethality rate of HepG-2 cells. Meanwhile, the Cur@CPC NMs show good anti-inflammatory activity, by which the secretion of inflammatory factors of IL-6 and TNF-α are inhibited. Overall, the developed Cur@CPC NMs show application prospects in anticancer drug delivery systems.

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Section: Resultsmentioning

confidence: 99%

Multifunctional β-Cyclodextrin–Poly(ethylene glycol)–Cholesterol Nanomicelle for Anticancer Drug Delivery

Yang

et al. 2022

ACS Appl. Bio Mater.

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“…Additionally, tumor cell, lysosomes and endosomes also have a lower pH (endosomal pH (pHen)) in comparison to pHex [ 203 , 204 ]. Therefore, pH-responsive nanoplatforms have been developed as an effective tumor treatment tool, greatly enhancing the tumor accumulation of the loaded therapeutic agents and facilitating the release of cargoes in the acidic tumoral microenvironment [ 205 ]. Currently, researchers typically use changes in chemical structure (such as changes in hydrophilicity through deprotonation and protonation) and acid-sensitive chemical bonds to design pH-responsive nanoplatforms (Fig.…”

Section: Stimuli-responsive Targeting Strategiesmentioning

confidence: 99%

Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies

et al. 2022

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Poor targeting of therapeutics leading to severe adverse effects on normal tissues is considered one of the obstacles in cancer therapy. To help overcome this, nanoscale drug delivery systems have provided an alternative avenue for improving the therapeutic potential of various agents and bioactive molecules through the enhanced permeability and retention (EPR) effect. Nanosystems with cancer-targeted ligands can achieve effective delivery to the tumor cells utilizing cell surface-specific receptors, the tumor vasculature and antigens with high accuracy and affinity. Additionally, stimuli-responsive nanoplatforms have also been considered as a promising and effective targeting strategy against tumors, as these nanoplatforms maintain their stealth feature under normal conditions, but upon homing in on cancerous lesions or their microenvironment, are responsive and release their cargoes. In this review, we comprehensively summarize the field of active targeting drug delivery systems and a number of stimuli-responsive release studies in the context of emerging nanoplatform development, and also discuss how this knowledge can contribute to further improvements in clinical practice.

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“…The loading capacity of DOX was 55.89%, which was higher than traditional drug delivery systems. 32–34 As shown in Fig. S21a and b (ESI†), compared with the DOX (absorption peak at 490 nm) and GluC (absorption peak at 450 nm), GluCCD showed two characteristic absorption peaks of DOX + Cu 2+ at 565 nm and GluCC at 470 nm.…”

mentioning

confidence: 95%

A glycol nanomedicine via a metal-coordination supramolecular self-assembly strategy for drug release monitoring and chemo-chemodynamic therapy

Li¹,

Wang²,

Pei³

et al. 2022

Chem. Commun.

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pH-Sensitive nanoparticles based on amphiphilic imidazole/cholesterol modified hydroxyethyl starch for tumor chemotherapy

Cited by 38 publications

References 66 publications

Multifunctional β-Cyclodextrin–Poly(ethylene glycol)–Cholesterol Nanomicelle for Anticancer Drug Delivery

Multifunctional β-Cyclodextrin–Poly(ethylene glycol)–Cholesterol Nanomicelle for Anticancer Drug Delivery

Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies

A glycol nanomedicine via a metal-coordination supramolecular self-assembly strategy for drug release monitoring and chemo-chemodynamic therapy

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