pH/thermo-responsive poly(N-isopropylacrylamide-co-maleic acid) hydrogel with a sensor and an actuator for biomedical applications

Fundueanu, Gheorghe; Constantin, Marieta; Bucatariu, Sanda; Ascenzi, Paolo

doi:10.1016/j.polymer.2017.01.003

Cited by 65 publications

(41 citation statements)

References 30 publications

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“…As reported in literature, the transition temperature of the network strictly depends on the hydrophilic/hydrophobic balance within the polymeric network. The insertion of hydrophilic moieties carried out an enhancement of the temperature required for both the disruption of polymer–water interactions and the establishment of hydrophobic interactions among the isopropyl groups within the polymer backbone allowing the hydrogel collapse …”

Section: Resultsmentioning

confidence: 99%

Chitosan–Quercetin Bioconjugate as Multi‐Functional Component of Antioxidants and Dual‐Responsive Hydrogel Networks

Cirillo

Curcio

Spizzirri

et al. 2019

Macro Materials & Eng

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Multifunctional hydrogels based on chitosan–quercetin (CHITQ) conjugate are prepared by a thermo‐induced radical procedure in the presence of N‐isopropylacrylamide (NIPAAm), acrylamide (AAm), and N,N′‐methylenebis(acrylamide) (MEBA). At first, quercetin (Q) is grafted onto chitosan backbone with a functionalization degree of 275 mg of Q per gram of conjugate, as calculated by 1H‐NMR analyses to impart antioxidant properties to the polysaccharide. Then, a pH and temperature sensitive hydrogel was obtained by involving CHITQ and NIPAAm in the polymerization reaction. The accessibility of phenolic moieties is modified in response to the hydrogel swelling/deswelling, as confirmed by antioxidant tests performed at different temperatures. Dual stimuli‐responsive hydrogels are proposed for the delivery of caffeine as model drug. The release profiles of caffeine depict a system particularly performing as on/off device at acidic pH with excellent applicability prospects.

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Section: Resultsmentioning

confidence: 99%

Chitosan–Quercetin Bioconjugate as Multi‐Functional Component of Antioxidants and Dual‐Responsive Hydrogel Networks

Cirillo

Curcio

Spizzirri

et al. 2019

Macro Materials & Eng

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“…Fundueanu et al . used a different strategy to synthesize a pH/temperature‐responsive system by developing a PNIPAAm‐ co ‐maleic acid copolymer and investigating the effect of pH and triggering agents on the polymer network . It was found that the polymer lost thermoresponsive properties at pH 7.4, but when a trigger molecule is introduced, like diphenhydramine (DPH), the negatively charged carboxylic groups in the polymer would interact with the positively charged moieties of the DPH, thereby activating the microgels and causing them to collapse, as depicted in Figure .…”

Section: Synthetic Smart Polymersmentioning

confidence: 99%

Multifunctional temperature‐responsive polymers as advanced biomaterials and beyond

Frazar

Shah

Dziubla

et al. 2019

J of Applied Polymer Sci

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The versatility and applicability of thermoresponsive polymeric systems have led to great interest and a multitude of publications. Of particular significance, multifunctional poly(N‐isopropylacrylamide) (PNIPAAm) systems based on PNIPAAm copolymerized with various functional comonomers or based on PNIPAAm combined with nanomaterials exhibiting unique properties. These multifunctional PNIPAAm systems have revolutionized several biomedical fields such as controlled drug delivery, tissue engineering, self‐healing materials, and beyond (e.g., environmental treatment applications). Here, we review these multifunctional PNIPAAm‐based systems with various cofunctionalities, as well as highlight their unique applications. For instance, addition of hydrophilic or hydrophobic comonomers can allow for polymer lower critical solution temperature modification, which is especially helpful for physiological applications. Natural comonomers with desirable functionalities have also drawn significant attention as pressure surmounts to develop greener, more sustainable materials. Typically, these systems also tend to be more biocompatible and biodegradable and can be advantageous for use in biopharmaceutical and environmental applications. PNIPAAm‐based polymeric nanocomposites are reviewed as well, where incorporation of inorganic or carbon nanomaterials creates synergistic systems that tend to be more robust and widely applicable than the individual components. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48770.

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“…Application of copolymers based on NIPMAM and NIPAM Polymers that have the capacity to alter their chemical and physical properties when exposed to various external stimuli [89] such as pH [90], temperature [91], mechanical force [92], ionic strength, magnetic and electric field are called 'intelligent' or 'smart' polymers. Hydrogels sensitive to environmental changes have immense potential in various applications [93].…”

Section: (1) (2018) 79-91mentioning

confidence: 99%

“…After 4 repeated uses of this system, the specific enzyme activity slightly diminishes [109]. Hydrogels obtained through copolymerization of NIPAM and N-hydroxysuccinimide, and later cross-linked with polylizine can be used as membrane 7(1) (2018) [79][80][81][82][83][84][85][86][87][88][89][90][91] immobilization systems for lipide vesicules [110]. Matsumoto et al developed new glucose-sensitive polymers responsive to physiological conditions (pH 7.4 i 37 °C) for the application in the form of a system for a selfregulating insuline injection in the treatment of diabetis melitus.…”

Section: (1) (2018) 79-91mentioning

confidence: 99%

“…The impact shows linear dependence on the fenol concentration, the number of fenol OH groups, as well as its relative positions. Derivatives of do-7(1) (2018) [79][80][81][82][83][84][85][86][87][88][89][90][91] pamine and amino fenols increase the phase transition temperature. Strong interactions between the molecules of dopamine are favorized, thus hindering the reactions of polymer-dopamin and leading to the crystallization of dopamine upon the removal of water.…”

Section: Introductionmentioning

confidence: 99%

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Hydrogels based on N-isopropylmethacrylamide and N-isopropylacrylamide

Urošević¹,

Nikolić²,

Ilić‐Stojanović³

et al. 2018

Adv Techol

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Hydrogels are three-dimensional polymer networks which have the capacity to retain a large quantity of water or biological fluids in the swollen state. Thermosensitive hydrogels have received special attention of reserachers since they represent a parameter which frequently changes in chemical, biological and physiological systems. Thermosensitive hydrogels have the critical solution temperature, i.e. they exhibit a substantial change in volume with the temperature change. Homopolymers poly(N-isopropylmethacrylamide) (poly(NIPMAM)) and poly(N-isopropylacrylamide) (poly(NIPAM)) are thermosensitive materials which have lately become the subject of intensive study. Monomer N-isopropylmethacrylamide, NIPMAM, enters into copolymerization with monomer N-isopropylacrylamide, NIPAM, in order to create a system with a phase transition temperature approximate to the human body temperature. In literature data there is available information on the synthesis and characterization of microgels, nanogels and copolymers based on NIPMAM and NIPAM. These thermosensitive polymer materials are used in controlled drug delivery and protein immobilization.

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pH/thermo-responsive poly(N-isopropylacrylamide-co-maleic acid) hydrogel with a sensor and an actuator for biomedical applications

Cited by 65 publications

References 30 publications

Chitosan–Quercetin Bioconjugate as Multi‐Functional Component of Antioxidants and Dual‐Responsive Hydrogel Networks

Chitosan–Quercetin Bioconjugate as Multi‐Functional Component of Antioxidants and Dual‐Responsive Hydrogel Networks

Multifunctional temperature‐responsive polymers as advanced biomaterials and beyond

Hydrogels based on N-isopropylmethacrylamide and N-isopropylacrylamide

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