pH triggered controlled drug delivery from contact lenses: Addressing the challenges of drug leaching during sterilization and storage

Maulvi, Furqan A.; Choksi, Harsh H.; Desai, Ankita R.; Patel, Akanksha S.; Ranch, Ketan M.; Vyas, Bhavin; Shah, Dinesh O.

doi:10.1016/j.colsurfb.2017.05.064

Cited by 72 publications

(60 citation statements)

References 41 publications

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“…Another approach of development of ocular drug delivery system was the use of a pH sensitive drug releasing system. 71 This work helped in developing a system which would also prevent drug leaching when the contact lens would be stored in a specic pH range. Drug release kinetics of two cases was studied -(a) normal contact lenses without nanoparticles in which the drug was loaded directly by the conventional soaking method; (b) nanoparticles of Eudragit S 100, a copolymer of methacrylic acid and methyl methacrylate, was incorporated in the contact lens.…”

Section: Use Of Nanoparticles For Ocular Drug Delivery By Contact Lensmentioning

confidence: 99%

“…Optical transparency is measured by calculating the transmittance percentage using an UV spectrophotometer in the range of 200-800 nm. 69,71 Depending on the chemical nature of the drug, different methods are adapted to measure the amount of drug uptake by the lens. Solvent extraction and colorimetric analysis are two of the important methods to study drug uptake and release.…”

Section: Evaluation Of Drug Laden Contact Lensmentioning

confidence: 99%

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Advances in chemistry and composition of soft materials for drug releasing contact lenses

et al. 2020

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Section: Use Of Nanoparticles For Ocular Drug Delivery By Contact Lensmentioning

confidence: 99%

Section: Evaluation Of Drug Laden Contact Lensmentioning

confidence: 99%

Advances in chemistry and composition of soft materials for drug releasing contact lenses

et al. 2020

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“…The optimized lenses had a 1:1 (drug: Eudragit) sustained the drug release over 156 h without affecting the optical and physical properties, whereas in rabbit tear fluids, sustained drug release for up to 14 days was observed. Moreover, no drug leaching was observed in the packaging solution, as confirmed from the packaging study [ 159 ].…”

Section: Nanocarriers For Anterior Segment Drug Deliverymentioning

confidence: 60%

Ocular Drug Delivery Barriers—Role of Nanocarriers in the Treatment of Anterior Segment Ocular Diseases

et al. 2018

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Ocular drug delivery is challenging due to the presence of anatomical and physiological barriers. These barriers can affect drug entry into the eye following multiple routes of administration (e.g., topical, systemic, and injectable). Topical administration in the form of eye drops is preferred for treating anterior segment diseases, as it is convenient and provides local delivery of drugs. Major concerns with topical delivery include poor drug absorption and low bioavailability. To improve the bioavailability of topically administered drugs, novel drug delivery systems are being investigated. Nanocarrier delivery systems demonstrate enhanced drug permeation and prolonged drug release. This review provides an overview of ocular barriers to anterior segment delivery, along with ways to overcome these barriers using nanocarrier systems. The disposition of nanocarriers following topical administration, their safety, toxicity and clinical trials involving nanocarrier systems are also discussed.

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“…The PVP-laden silicone contact lenses were kept individually in a glass vial containing 2 mL of STF at 34 °C in an incubator shaker at 100 rpm. 33 To maintain the sink condition, the STF was replaced with the same volume of fresh STF media at regular time intervals until the PVP was detected. The amount of PVP released was quantified by a UV–visible spectrophotometer (colorimetric method) at 420 nm using citric acid and iodine–KI solution (for more details, see Supporting Information II ).…”

Section: Methodsmentioning

confidence: 99%

Novel Poly(vinylpyrrolidone)-Coated Silicone Contact Lenses to Improve Tear Volume During Lens Wear: In Vitro and In Vivo Studies

et al. 2020

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Poly(vinylpyrrolidone) (PVP-K90) is widely used to manage dry eye syndrome (DES). The marketed eye drop solutions (high dose) need frequent instillation, affecting the routine lifestyle of patients. PVP-K90-laden contact lenses can be used to overcome the limitations of eye drop solutions (low bioavailability and frequent instillation). However, the conventional methods of PVP-K90 loading show poor loading capacity and short duration of effect. In the present study, we have developed PVP-K90-coated contact lenses via a short curing approach to increase the PVP-K90 loading capacity with a sustained release profile to manage dry eye syndrome. PVP-K90 was loaded by a soaking method (SM-PVP), direct loading (during fabrication, DL-PVP), a combination of soaking and direct loading (DL-SM-PVP), and a novel coating process (SM-PVP-C and DL-SM-PVP-C). The swelling studies suggested improvement in the water uptake (hydration) property of the contact lenses due to the presence of PVP-K90. The optical transparency was within an acceptable range. The in vitro release of PVP-K90 was in the following order: PVP-coated contact lens (168 h) > DL-SM-PVP (168 h) > DL-PVP (96 h) > SM-PVP (72–96 h). PVP-coated contact lenses showed a high burst effect (lubricating effect) and sustained release (3161–448 ng/h between 24 and 168 h) due to high PVP loading/coating in comparison to the uncoated respective contact lenses (964–113 ng/h between 24 and 96 h). In animal studies, the PVP-K90-coated contact lens showed higher tear volume in comparison to the respective uncoated contact lenses and an eye drop solution. This study demonstrates a novel approach of coating a high amount of PVP-K90 on contact lenses for sustained release to manage several ocular diseases like dry eye syndrome, conjunctivitis, and other ocular injuries.

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pH triggered controlled drug delivery from contact lenses: Addressing the challenges of drug leaching during sterilization and storage

Cited by 72 publications

References 41 publications

Advances in chemistry and composition of soft materials for drug releasing contact lenses

Advances in chemistry and composition of soft materials for drug releasing contact lenses

Ocular Drug Delivery Barriers—Role of Nanocarriers in the Treatment of Anterior Segment Ocular Diseases

Novel Poly(vinylpyrrolidone)-Coated Silicone Contact Lenses to Improve Tear Volume During Lens Wear: In Vitro and In Vivo Studies

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