PHA Response of Blood and Lymph Node Lymphocytes &lt;i&gt;in vitro&lt;/i&gt; in Malignant Lymphomas

Navone, Roberto; Stramignoni, A

doi:10.1159/000208279

Cited by 6 publications

(2 citation statements)

References 15 publications

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“…It appears, however, that single results of patients with 'disseminated' disease may seem completely normal both in Hodgkin's disease and in solid tumors. Methodological differences and individual differences of reactivity, therefore, may possibly explain why previous investigations of immune reactivity have yielded conflicting results, both in Hodgkin's disease (Denton 1973, Levy & Kaplan 1974, Navone & Stramigioni 1974 and in solid tumors (Garrioch et a1 1970, Paty & Bone 1973. The present study failed to detect any immunological aberration specific to Hodgkin's disease.…”

Section: Reactivity and Stimulatory Capacity In Mlccontrasting

confidence: 66%

Blood B and T Lymphocytes and In Vitro Cellular Immune Reactivity in Untreated Human Malignant Lymphomas and Other Malignant Tumors

Heier

Klepp

Gundersen

et al. 1977

Scandinavian Journal of Haematology

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Peripheral blood lymphocytes and their in vitro reactivity have been recorded prior to treatment in 18 patients with Hodgkin's disease, 11 with lymphosarcoma, 13 with reticulosarcoma, 20 with various solid tumors and 37 normal control persons. The mean total numbers of lymphocytes, those of T lymphocytes, and the mean reactivities to PHA and ConA were reduced in all groups except lymphosarcoma, although with varying degrees of statistical significance. The percentages of T and B lymphocytes appeared to be normal in all groups, but the ranges of values were somewhat greater than among the normal controls. The mean total numbers of B lymphocytes were normal in all patient groups. All reductions seemed to be more pronounced in patients with disseminated than in those with localized disease, but none of these differences was statistically significant. All patient groups appeared to have reduced reactivity in MLC, while the ability to stimulate control lymphocytes was nearly normal. The results fail to indicate any in vitro immunological abberation specific to Hodgkin's disease. It seems that human malignant, neoplastic diseases are associated with a relatively selective reduction of the total numbers and reactivity of blood T lymphocytes. Various explanations of the reactivity impairment are proposed. The pathogenesis of the reduction of the total number of blood T lymphocytes remains obscure.

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Section: Reactivity and Stimulatory Capacity In Mlccontrasting

confidence: 66%

Blood B and T Lymphocytes and In Vitro Cellular Immune Reactivity in Untreated Human Malignant Lymphomas and Other Malignant Tumors

Heier

Klepp

Gundersen

et al. 1977

Scandinavian Journal of Haematology

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“…It is known that non-Hodgkin lymphomas and C. L.L. lymphocytes with Ig surface membrane (B lymphocytes) are very increased both in pery pheral blood and in lymph node suspensions [ 1, 2, 3, 5, 9, 13, 14, 16, 18, 21], whereas, on the contrary, E rosetting and PHA responsive cells (T lymphocytes) show levels lower than normal [2,14,15], Similar immunological modifications were present in 4 out of 6 patients examined (table I): 2 with generalised lymphoma and gastric involvement and 2 out of 4 with primary striking gastric lymphoid ''hyperplasia" . These modifications exceeded widely the range of the normal values (table l) and, in parti cular, both T and B cells show quantitative differences more marked than those of controls with comparable age.…”

Section: Discussionmentioning

confidence: 99%

Primary Gastric Lymphoid Proliferations: Immunological Criteria to Distinguish Gastric Lymphoma from Reactive Hyperplasia

Palestro¹,

Poggio²,

Leonardo³

et al. 1977

Oncology

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A group of six patients with a marked gastric lymphoid “hyperplasia”, two of these with generalised lymphoma and the others suspected for primary gastric lymphoma, were investigated to discriminate between simple reactive hyperplasias and lymphomatous proliferations. Microscopical and ultrastructural examinations were not useful for this purpose but immunological data can give evidence of a two-fold nature of gastric lymphoid hyperplasia. Some cases are without immunological disorders, others are met with peripheral blood signs of immunological alterations similar to those observed in malignant lymphomas and in chronic lymphocytic leukemia. Only these latter cases should, in our opinion, be regarded as primitive gastric lymphomas.

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Immunodeficiencies Associated with Chronic Lymphocytic Leukemia and Non–Hodgkin’s Lymphomas

Gupta

Good

1978

The Immunopathology of Lymphoreticular Neoplasms

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PHA Response of Blood and Lymph Node Lymphocytes <i>in vitro</i> in Malignant Lymphomas

Cited by 6 publications

References 15 publications

Blood B and T Lymphocytes and In Vitro Cellular Immune Reactivity in Untreated Human Malignant Lymphomas and Other Malignant Tumors

Blood B and T Lymphocytes and In Vitro Cellular Immune Reactivity in Untreated Human Malignant Lymphomas and Other Malignant Tumors

Primary Gastric Lymphoid Proliferations: Immunological Criteria to Distinguish Gastric Lymphoma from Reactive Hyperplasia

Immunodeficiencies Associated with Chronic Lymphocytic Leukemia and Non–Hodgkin’s Lymphomas

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