Phaeohyphomycosis presenting as a solitary nodulocystic lesion in a renal transplant patient

Kumar, Gopinathan Nanda; Nair, Sukumaran Pradeep

doi:10.4103/2229-5178.164468

Cited by 3 publications

(2 citation statements)

References 6 publications

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“…Phaeohyphomycosis (PH) are a rare group of heterogenous dematiaceous (phaeoid) brown pigment producing fungi, which cause superficial, cutaneous, and subcutaneous infections in the immunocompetent and systemic illness, especially brain abscesses in the immunosuppressed. [2] A myriad of fungal species causes this unique infection, which includes Exophiala, Phialophora, Cladosporium, Wangiella, Fonsacaea, Alternaria, Bipolaris,and Curvularia species. The usual source of infection is usually exogenous, following pricks with thorns or wood splinters.…”

Section: Introductionmentioning

confidence: 99%

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Melanized fungus as an Epidural abscess: A diagnostic and therapeutic challenge

Shrivastava

Karuna

Goel

et al. 2017

Medical Mycology Case Reports

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Curvularia a dematiaceous fungus is ubiquitously found in soil around the world. We report an epidural abscess due to Curvularia lunata in a 48 years male farmer who underwent decompressive laminectomy as primary modality of treatment followed by isolation, identification and confirmation of the isolate from tissue by ITS sequencing. Antifungal therapy with voriconazole and amphotericin B for 3 and 2 weeks respectively improved patient's condition and is presently on regular follow up with no sequelae since last 7 months.

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Section: Introductionmentioning

confidence: 99%

“…The usual source of infection is usually exogenous, following pricks with thorns or wood splinters. [2] .…”

Section: Introductionmentioning

confidence: 99%

Melanized fungus as an Epidural abscess: A diagnostic and therapeutic challenge

Shrivastava

Karuna

Goel

et al. 2017

Medical Mycology Case Reports

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Phaeohyphomycosis due to Exophiala infections in solid organ transplant recipients: Case report and literature review

Oberlin

Nichols

Rosa

et al. 2017

Transplant Infectious Dis

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This case report and literature review underscores the cutaneous presentations of phaeohyphomycosis in the solid organ transplant population. Increased cognizance with prompt identification is critical. The therapy and clinical outcomes of phaeohyphomycosis, caused by the Exophiala genus, in the solid organ transplant population, is analyzed to examine optimal care. This review highlights the inherent difficulties in providing the appropriate duration of antifungal therapy to avoid relapsing infections in immunosuppressed patients.

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Diagnostic challenges of a spectrum of cases of Phaeohyphomycosis - A histopathological approach of rare dematiaceous (Melanized / pigmented) fungi

Barathi¹,

Thanka²,

Shalini³

2020

ACHR

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Background: Dematiaceous fungi are a group of melanized fungi which imparts light to dark golden brown colour to the cell wall of these fungi on histopathological tissue sections (HPE). Due to lack of clinical suspicion and varied clinico-pathological presentation they are easily mistaken for any chronic swelling. The three common melanized fungi are phaeohyphomycosis, mycetoma, and chromoblastomycosis. Aim: Our study aims at deriving an algorithm for diagnosing these fungi on HPE. Materials and Methods: This is a retrospective study conducted on paraffin blocks of histopathology proven phaeohyphomycosis and mycetoma retrieved from the surgical pathology case files. Special stains for fungus were done for confirmation. Results: Out of 34 cases 29 were phaeohyphomycosis and 5 were mycetoma which included both immunocompromised and immunocompetent patients. Interestingly it was observed that most of the cases presented with a trivial penetrating injury or a minor trauma. These melanized fungi were further distinguished on their clinical presentation and morphological features. Conclusion: Because of their chronicity and localized lesion, most of the cases undergo surgical excision which itself is curative. Clinically and radiologically undiagnosed cases are primarily diagnosed on HPE after surgical excision in many cases. Hence a diagnosis of these melanized fungi on HPE needs an approach which would be beneficial to all practicing pathologists if they come across such rare cases.

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Phaeohyphomycosis presenting as a solitary nodulocystic lesion in a renal transplant patient

Cited by 3 publications

References 6 publications

Melanized fungus as an Epidural abscess: A diagnostic and therapeutic challenge

Melanized fungus as an Epidural abscess: A diagnostic and therapeutic challenge

Phaeohyphomycosis due to Exophiala infections in solid organ transplant recipients: Case report and literature review

Diagnostic challenges of a spectrum of cases of Phaeohyphomycosis - A histopathological approach of rare dematiaceous (Melanized / pigmented) fungi

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