Phaeophytin and Triterpenoids from Brachystelma togoense Schltr, a Nigerian Medicinal Herb

Abstract

The medicinal herb Brachystelma togoense schtlr (Apocynaceae) is used traditionally for treatment of ailments. The secondary metabolites, phaeophytin a, α-amyrin and lupeol were isolated from the CH2Cl2 and MeOH extracts of Brachystelma togoense. The structures were elucidated using 1H, 13C and 2D NMR. These phytochemicals have previously being reported to have various biological activities such as anti-inflammatory, anti-fungal and anti-cancer. The presence of phaeophytin a, α-amyrin and lupeol in Brachystelma togoense justified the use of the plant for medicinal purpose in Nigeria.

Isolation of Pheophytin A and β-amyrin from Newbouldia laevis (P. Beauv) Leaf Extract

“…The 13C NMR Spectrum showed 55 carbons, with a carbonyl at σ173.1 (C-17 3 ) in NLM24, suggesting an esterified position. One oxymethylene (σc61.58), Ten methyl carbons at σ129.1 (C-3 1 ), σ97.9 (C-5), σ104.2 (C-10), σ64.9 (C-13 2 ), σ51.9…”

“…Pheophytin A and β-amyrin have been naturally isolated from plants such as Brachystelma togoense Schltr, and Protium heptaphyllum [3,4]. Pheophytin A was reported to possess numerous biological activities such as anti-cancer, antifungal and anti-inflammatory [3], while β-amyrin was found to have antihyperglycemic and hypolipidemic effects [4].…”

A Bioactive dihydroflavonol-3-O-α-L-rhamnoside from Bracystelma togoense Schtlr

“…The aerial parts of Brachystelma togoense was collected in the month of April 2018 from Benue State, Nigeria. The plant was identified by the plant taxonomist Mallam Sanusi Namadi and a voucher specimen ( 25856) is retained in Biological Science Depatment, Ahmadu Bello University, Zaria-Nigeria (Ekalu et al, 2019).…”