Phage display allows identification of zona pellucida-binding peptides with species-specific properties: Novel approach for development of contraceptive vaccines for wildlife

Samoylova, Tatiana I.; Cochran, Anna M.; Samoylov, Alexandre M.; Schemera, Bettina; Breiteneicher, Adam H.; Ditchkoff, Stephen S.; Petrenko, Valery A.; Cox, Nancy R.

doi:10.1016/j.jbiotec.2012.10.006

Cited by 21 publications

(19 citation statements)

References 48 publications

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“…Most of them have been developed using specific sperm antibodies (competitor or inhibitor) to prevent the binding of a candidate protein to the ZP or oocyte membrane. More global approaches have also been developed such as phage display technology (Naz 2005, Samoylova et al 2012, and the ZP affinity properties of sperm proteins have been analysed using different global and selective proteomic approaches (Stein et al 2006, Brewis & Gadella 2010, Belleannee et al 2011a, Petit et al 2013. Many protein candidates have been proposed following these in vitro studies, and more than 50 proteins have already been reported to be involved in sperm-egg interactions (Supplementary Table 1).…”

Section: Epididymal Surroundings and Sperm Proteins Involved In Egg-bmentioning

confidence: 99%

New insights into epididymal function in relation to sperm maturation

2014

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Testicular spermatozoa acquire fertility only after 1 or 2 weeks of transit through the epididymis. At the end of this several meters long epididymal tubule, the male gamete is able to move, capacitate, migrate through the female tract, bind to the egg membrane and fuse to the oocyte to result in a viable embryo. All these sperm properties are acquired after sequential modifications occurring either at the level of the spermatozoon or in the epididymal surroundings. Over the last few decades, significant increases in the understanding of the composition of the male gamete and its surroundings have resulted from the use of new techniques such as genome sequencing, proteomics combined with high-sensitivity mass spectrometry, and gene-knockout approaches. This review reports and discusses the most relevant new results obtained in different species regarding the various cellular processes occurring at the sperm level, in particular, those related to the development of motility and egg binding during epididymal transit.

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Section: Epididymal Surroundings and Sperm Proteins Involved In Egg-bmentioning

confidence: 99%

New insights into epididymal function in relation to sperm maturation

2014

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“…Recognition of sperm antigens that participate in sperm-ZP binding can be achieved using phage display techniques (Eidne et al 2000;Naz 2005). This approach has since enabled identification of putatively pig-specific phage antigens that stimulate production of sperm-binding antibodies with potential for immunocontraception (Samoylova et al 2012).…”

Section: Immunocontraceptive Vaccinesmentioning

confidence: 99%

Fertility control to mitigate human–wildlife conflicts: a review

2014

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Abstract. As human populations grow, conflicts with wildlife increase. Concurrently, concerns about the welfare, safety and environmental impacts of conventional lethal methods of wildlife management restrict the options available for conflict mitigation. In parallel, there is increasing interest in using fertility control to manage wildlife. The present review aimed at analysing trends in research on fertility control for wildlife, illustrating developments in fertility-control technologies and delivery methods of fertility-control agents, summarising the conclusions of empirical and theoretical studies of fertility control applied at the population level and offering criteria to guide decisions regarding the suitability of fertility control to mitigate human-wildlife conflicts. The review highlighted a growing interest in fertility control for wildlife, underpinned by increasing numbers of scientific studies. Most current practical applications of fertility control for wild mammals use injectable single-dose immunocontraceptive vaccines mainly aimed at sterilising females, although many of these vaccines are not yet commercially available. One oral avian contraceptive, nicarbazin, is commercially available in some countries. Potential new methods of remote contraceptive delivery include bacterial ghosts, virus-like particles and genetically modified transmissible and non-transmissible organisms, although none of these have yet progressed to field testing. In parallel, new species-specific delivery systems have been developed. The results of population-level studies of fertility control indicated that this approach may increase survival and affect social and spatial behaviour of treated animals, although the effects are species-and context-specific. The present studies suggested that a substantial initial effort is generally required to reduce population growth if fertility control is the sole wildlife management method. However, several empirical and field studies have demonstrated that fertility control, particularly of isolated populations, can be successfully used to limit population growth and reduce human-wildlife conflicts. In parallel, there is growing recognition of the possible synergy between fertility control and disease vaccination to optimise the maintenance of herd immunity in the management of wildlife diseases. The review provides a decision tree that can be used to determine whether fertility control should be employed to resolve specific human-wildlife conflicts. These criteria encompass public consultation, considerations about animal welfare and feasibility, evaluation of population responses, costs and sustainability.

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“…There are no registered contraceptives available for use in wild pigs in the United States, but advancements with immunocontraceptive vaccine injections have short‐term success in making individuals infertile (Killian et al , Massei et al ). Research to develop oral contraceptives, phage display, and cytotoxins that target oocytes is also being conducted (Samoylova et al ; D. C. Eckery, USDA Animal Plant Health Inspection Service, personal communication). Oral contraceptives could potentially be administered on a broad scale, but pig‐specific delivery methods will be required to ensure they are not consumed by non‐target species.…”

Section: Research Prioritiesmentioning

confidence: 99%

Research priorities for managing invasive wild pigs in North America

et al. 2018

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With recent increases in distribution and numbers of feral pigs (Sus scrofa; invasive wild pigs) in North America, there has been a concurrent increase in the ecological and economic effects they have had on native and anthropogenic ecosystems. Despite the amplified interest in invasive wild pig research, there remains a significant knowledge gap regarding their basic biology and ecology, the scope of the damage they cause, and the efficacy of many control strategies. Such information is important to support the successful management of invasive wild pigs throughout North America and other areas. In 2016, members of the National Wild Pig Task Force met and developed a set of research priorities to aid in effective management of invasive wild pigs. These research priorities identify 4 topical areas where increased effort and science is most needed to manage invasive wild pigs: biology and ecology, economic and ecological damages, control strategies, and education and human dimensions, with particular emphasis on areas where specific data gaps remain within each topical area. Resolution of such knowledge deficits would advance the understanding of invasive wild pig ecology, enabling more efficient and effective management of this species. Ó 2018 The Wildlife Society.

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Phage display allows identification of zona pellucida-binding peptides with species-specific properties: Novel approach for development of contraceptive vaccines for wildlife

Cited by 21 publications

References 48 publications

New insights into epididymal function in relation to sperm maturation

New insights into epididymal function in relation to sperm maturation

Fertility control to mitigate human–wildlife conflicts: a review

Research priorities for managing invasive wild pigs in North America

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