Phage-Displayed Recombinant Peptides for Non-Invasive Imaging Assessment of Tumor Responsiveness to Ionizing Radiation and Tyrosine Kinase Inhibitors

Wang, Hailun; Han, Miaojun; Han, Zhibin

doi:10.5772/33860

Cited by 3 publications

(3 citation statements)

References 77 publications

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“…Phage display technology offers potential tools for development of therapeutic agents, vaccines, diagnostic reagents, as well as gene and drug delivery systems . Determination of interaction partners of organic (proteins, polysaccharides or DNAs) or inorganic compounds and also in vitro protein engineering are the major applications of phage display technology . More recently, a number of attempts have been made for using in vitro phage display technology in medical science by designing humanized antibodies or peptides and development of new pharmaceutics for various maladies such as cancer, autoimmune and inflammatory diseases, metabolic and allergic disorders .…”

Section: Applications Of Bacteriophagesmentioning

confidence: 99%

Bacteriophages: an overview of the control strategies against multiple bacterial infections in different fields

et al. 2018

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Bacteriophages (phages/viruses) need host bacteria to replicate and propagate.Primarily, a bacteriophage contains a head/capsid to encapsidate the genetic material. Some phages contain tails. Phages encode endolysins to hydrolyze bacterial cell wall.The two main classes of phages are lytic or virulent and lysogenic or temperate. In comparison with antibiotics, to deal with bacterial infections, phage therapy is thought to be more effective. In 1921, the use of phages against bacterial infections was first demonstrated. Later on, in humans, phage therapy was used to treat skin infections caused by Pseudomonas species. Furthermore, phages were successfully employed against infections in animalscalves, lambs, and pigs infected with Escherichia coli. In agriculture, for instance, phages have successfully been used e.g., Apple blossom infection, caused by Erwinia amylovora, was effectively catered with the use of bacteriophages. Bacteriophages were also used to control E. coli, Salmonella, Listeria, and Campylobacter contamination in food. Comparatively, phage display is a recently discovered technology, whereby, bacteriophages play a significant role. This review is an effort to collect almost recent and relevant information regarding applications and complications associated with the use of bacteriophages.

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Section: Applications Of Bacteriophagesmentioning

confidence: 99%

Bacteriophages: an overview of the control strategies against multiple bacterial infections in different fields

et al. 2018

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“…The most common bacteriophages used in the "phage display" technique are M13 and filamentous phage, although T4, T7, and λ phages have also been used. 22,23 Despite the advantages of using phage in cancer studies, there are also disadvantages, for example, in vitro panning using cell lines may lead to the selection of peptides that behave differently in vivo; phages are currently difficult to prepare for use in humans and animals; most in vivo phage studies are performed on animal models; and it is complicated to determine the dose of phages being administered and the duration of the effect. 24,25 F I G U R E 1 Various applications of complete phages, capsid proteins, and phage-derived peptides in therapeutic and diagnostic approaches such as cancer vaccines development, in vitro/vivo tumor detection, and tumor-targeted delivery of therapeutic agents/imaging dyes.…”

Section: Bacteriophage and Phage Display Techniquementioning

confidence: 99%

“…Production of different phage peptide libraries using phage display was an important milestone in the introduction of phages to the arena of anticancer research 19,21 (Figure 1). The most common bacteriophages used in the “phage display” technique are M13 and filamentous phage, although T4, T7, and λ phages have also been used 22,23 . Despite the advantages of using phage in cancer studies, there are also disadvantages, for example, in vitro panning using cell lines may lead to the selection of peptides that behave differently in vivo; phages are currently difficult to prepare for use in humans and animals; most in vivo phage studies are performed on animal models; and it is complicated to determine the dose of phages being administered and the duration of the effect 24,25 …”

Section: Bacteriophage and Phage Display Techniquementioning

confidence: 99%

New role of bacteriophages in medical oncology

Moradi,

Ghaleh,

Bolandian

et al. 2023

Biotech and App Biochem

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Targeted treatment of cancer is one of the most paramount approaches in cancer treatment. Despite significant advances in cancer diagnosis and treatment methods, there are still significant limitations and disadvantages in the field, including high costs, toxicity, and unwanted damage to healthy cells. The phage display technique is an innovative method for designing carriers containing exogenic peptides with cancer diagnostic and therapeutic properties. Bacteriophages possess unique properties making them effective in cancer treatment. These characteristics include the small size enabling them to penetrate vessels; having no pathogenicity to mammals; easy manipulation of their genetic information and surface proteins to introduce vaccines and drugs to cancer tissues; lower cost of large‐scale production; and greater stimulation of the immune system. Bacteriophages will certainly play a more effective role in the future of medical oncology; however, studies are in the early stages of conception and require more extensive research. We aimed in this review to provide some related examples and bring insights into the potential of phages as targeted vectors for use in cancer diagnosis and treatment, especially regarding their capability in gene and drug delivery to cancer target cells, determination of tumor markers, and vaccine design to stimulate anticancer immunity.

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Advances in phage display technology for drug discovery

Omidfar¹,

Daneshpour

2015

Expert Opinion on Drug Discovery

106

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Advances in screening, manufacturing and humanization technologies demonstrate that phage display derived products can play a significant role in the diagnosis and treatment of disease. The effects of this technology are inevitable in the development pipeline for bringing therapeutics into the market, and this number is expected to rise significantly in the future as new advances continue to take place in display methods. Furthermore, a widespread application of this methodology is predicted in different medical technological areas, including biosensing, monitoring, molecular imaging, gene therapy, vaccine development and nanotechnology.

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Phage-Displayed Recombinant Peptides for Non-Invasive Imaging Assessment of Tumor Responsiveness to Ionizing Radiation and Tyrosine Kinase Inhibitors

Cited by 3 publications

References 77 publications

Bacteriophages: an overview of the control strategies against multiple bacterial infections in different fields

Bacteriophages: an overview of the control strategies against multiple bacterial infections in different fields

New role of bacteriophages in medical oncology

Advances in phage display technology for drug discovery

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