Phage-Specific Diverse Effects of Bacterial Viruses on the Immune System

Górski, Andrzej; Międzybrodzki, Ryszard; Jończyk‐Matysiak, Ewa; Żaczek, Maciej; Borysowski, Jan

doi:10.2217/fmb-2019-0222

Cited by 26 publications

(26 citation statements)

References 29 publications

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“…Those assumptions have been fully confirmed by the recent data of other authors (Barr et al, 2013a,b;Lehti et al, 2017;Nguyen et al, 2017;Barr, 2019). Moreover, we have further advanced our hypothesis by pointing out that various phages may mediate different immunomodulatory functions (Górski et al, 2019b).…”

Section: Democratic Transition In Polandsupporting

confidence: 89%

Phage Therapy in Poland – a Centennial Journey to the First Ethically Approved Treatment Facility in Europe

et al. 2020

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Although phage discovery is an unquestionable merit of the English bacteriologist Frederick W. Twort and the Canadian-French microbiologist Félix d'Hérelle, who both discovered phages over 100 years ago, the Polish history of phage studies also dates back to those years. In contrast to the Western world, developing phage treatment in Poland has never been abandoned despite the country's tense history marked by the Second World War (WWII) and the communism era. Today, Poland takes a prominent and remarkable place in the phage research area. Furthermore, established in 2005, the Phage Therapy Unit at the Hirszfeld Institute of Immunology and Experimental Therapy in Wrocław, the first such center within European borders, has quickly become a model for other centers in the world facing the issue of widespread antibiotic resistance. This article constitutes an attempt to fill the gap in the scientific literature by providing a comprehensive summary of the long tradition of phage research in Poland.

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Section: Democratic Transition In Polandsupporting

confidence: 89%

Phage Therapy in Poland – a Centennial Journey to the First Ethically Approved Treatment Facility in Europe

et al. 2020

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“…Both T4 and A5/80 phages may cause a high overexpression of the HSA1 gene coding a heat shock protein, Hsp70, in human alveolar cells [ 15 ]. This well-known cellular chaperone may protect cells undergoing transcytosis from potential injury by cellular phages [ 16 ]. On the other hand, expression of another heat shock protein Hsp90, may be downregulated by T4 and M13 phages [ 17 ].…”

Section: Phages May Penetrate Epithelial Cells Protect Those Epithelmentioning

confidence: 99%

Phages in the Fight Against COVID-19?

et al. 2020

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“…Successful phage therapy can be greatly affected by immune deficiencies of organisms undergoing treatment, which has already been shown on the human model [95][96][97][98]. Furthermore, phages are capable of influencing the immune system of eukaryotes in a variety of ways [99,100]. In aquatic hatcheries, fish are subjected to constant stress due to the extensive use of antibiotics and other drugs and overstocking.…”

Section: Fish Immunitymentioning

confidence: 99%

Phages as a Cohesive Prophylactic and Therapeutic Approach in Aquaculture Systems

2020

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Facing antibiotic resistance has provoked a continuously growing focus on phage therapy. Although the greatest emphasis has always been placed on phage treatment in humans, behind phage application lies a complex approach that can be usefully adopted by the food industry, from hatcheries and croplands to ready-to-eat products. Such diverse businesses require an efficient method for combating highly pathogenic bacteria since antibiotic resistance concerns every aspect of human life. Despite the vast abundance of phages on Earth, the aquatic environment has been considered their most natural habitat. Water favors multidirectional Brownian motion and increases the possibility of contact between phage particles and their bacterial hosts. As the global production of aquatic organisms has rapidly grown over the past decades, phage treatment of bacterial infections seems to be an obvious and promising solution in this market sector. Pathogenic bacteria, such as Aeromonas and Vibrio, have already proved to be responsible for mass mortalities in aquatic systems, resulting in economic losses. The main objective of this work is to summarize, from a scientific and industry perspective, the recent data regarding phage application in the form of targeted probiotics and therapeutic agents in aquaculture niches.

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Phage-Specific Diverse Effects of Bacterial Viruses on the Immune System

Cited by 26 publications

References 29 publications

Phage Therapy in Poland – a Centennial Journey to the First Ethically Approved Treatment Facility in Europe

Phage Therapy in Poland – a Centennial Journey to the First Ethically Approved Treatment Facility in Europe

Phages in the Fight Against COVID-19?

Phages as a Cohesive Prophylactic and Therapeutic Approach in Aquaculture Systems

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