Phagocytic functions of salivary neutrophils in oral mucous membrane diseases

Lukač, Josip; Stipetić, Marinka Mravak; Knežević, Marjana; Vrček, Jurica; Sistig, Suzana; Ledinsky, Mario; Kusić, Zvonko

doi:10.1034/j.1600-0714.2003.00127.x

Cited by 24 publications

(23 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…They compare phagocytic function of salivary neutrophils of healthy volunteers with their activity in patients suffered from oral lichen planus and acute recurrent aphtous ulceration. Our experience is similar (the nurses study): oral mucositis turned to better just after appearance of neurtophils in oral fluid 21 . The radicality of the stomatological preparation of the patients before stem cell transplantation and before surgery must be also carefully considered.…”

Section: Its Therapeutic Effect On Inflammatory Parodontal Disease Issupporting

confidence: 59%

Salivary Neutrophils Level as an Indicator of Bone Marrow Engraftment

Pink¹,

Vondráková²,

Tvrdý³

et al. 2009

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

View full text Add to dashboard Cite

Section: Its Therapeutic Effect On Inflammatory Parodontal Disease Issupporting

confidence: 59%

Salivary Neutrophils Level as an Indicator of Bone Marrow Engraftment

Pink¹,

Vondráková²,

Tvrdý³

et al. 2009

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

View full text Add to dashboard Cite

“…It seems reasonable, therefore, to assume similar responses would have occurred in the present study. Neutrophils continually migrate into the saliva/oral fluids from the blood, predominantly via gingival crevices (Bender et al 2006;Lukac et al 2003) so an increase in neutrophil numbers in saliva is likely to occur when blood neutrophils counts are increased to such an extent although further study is required to confirm this. Furthermore, exercise has also been shown to induce neutrophil priming and activation (Pyne 1994;Smith and Pyne 1997), which could result in increased secretion, into saliva, of HNP1-3 and LL-37 from local neutrophils.…”

Section: Discussionmentioning

confidence: 96%

Salivary antimicrobial peptides (LL-37 and alpha-defensins HNP1–3), antimicrobial and IgA responses to prolonged exercise

2009

View full text Add to dashboard Cite

There are many factors in mucosal secretions that contribute to innate immunity and the 'first line of defence' at mucosal surfaces. Few studies, however, have investigated the effects of exercise on many of these 'defence' factors. The aim of the present study was to determine the acute effects of prolonged exercise on salivary levels of selected antimicrobial peptides (AMP) that have not yet been studied in response to exercise (HNP1-3 and LL-37) in addition to immunoglobulin A (IgA). A secondary objective was to assess the effects of exercise on saliva antibacterial capacity. Twelve active men exercised on a cycle ergometer for 2.5 h at approximately 60% of maximal oxygen uptake. Unstimulated whole saliva samples were obtained before and after exercise. There was a significant decrease (P < 0.05) in salivary IgA:osmolality ratio, following exercise, but IgA concentration and secretion rate were unaltered. Salivary HNP1-3 and LL-37 concentrations (P < 0.01 and P < 0.05, respectively), concentration:osmolality ratios (P < 0.01) and secretion rates (P < 0.01) all increased following exercise. Salivary antibacterial capacity (against E. coli) did not change. The increased concentration of AMPs in saliva may confer some benefit to the 'first line of defence' and could result from synergistic compensation within the mucosal immune system and/or airway inflammation and epithelial damage. Further study is required to determine the significance of such changes on the overall 'defence' capacity of saliva and how this influences the overall risk for infection.

show abstract

“…In addition, suicide of neutrophils has been shown to be an important defense mechanism of these cells [4]. However, neutrophils are the major cells infiltrating saliva and protecting against oral infections [37][38][39][40][41][42][43][44][45][46]. Therefore, neutrophils from DS patients have functional alterations when challenged with C. albicans, and these features may widely be correlated to a major vulnerability of Candida-related denture stomatitis in these individuals.…”

Section: Discussionmentioning

confidence: 98%

Activation pattern of neutrophils from blood of elderly individuals with Candida-related denture stomatitis

Gasparoto

Oliveira

Vieira

et al. 2011

Eur J Clin Microbiol Infect Dis

View full text Add to dashboard Cite

We have identified impaired neutrophils in elderly individuals which could be involved with Candida-related denture stomatitis (DS), an oral infection predominantly caused by Candida albicans, affecting especially elderly individuals using dental prosthesis. However, specific mechanisms performed by neutrophil contributing to the susceptibility of the elderly to DS are not fully understood. This study evaluated activation features of blood neutrophils from elderly and young individuals with DS. Blood neutrophils cultured with C. albicans from elderly subjects secreted decreased levels of CXCL8. However, C. albicans challenged-neutrophils from DS patients produced high IL-4 and IL-10, and low GM-CSF levels, regardless of age. Additional elastase activity of neutrophils from both elderly groups was detected after incubation with C. albicans, but only neutrophils from elderly DS demonstrated high myeloperoxidase activity. Therefore, DS patients have affected neutrophils, and the advance of age intensifies these damages. In summary, individuals with Candida-related denture stomatitis presented variation in the neutrophil phenotype and activation. Such alterations were more intense in neutrophils from infected elderly individuals.

show abstract

Phagocytic functions of salivary neutrophils in oral mucous membrane diseases

Abstract: Salivary PMNs present functional features distinct from those in peripheral blood. Some phagocytic functions of sPMNs are reduced in RAU and enhanced in OLP, indicating their role in pathogenesis or reflecting clinical changes in these conditions.

Cited by 24 publications

References 12 publications

Salivary Neutrophils Level as an Indicator of Bone Marrow Engraftment

Salivary Neutrophils Level as an Indicator of Bone Marrow Engraftment

Salivary antimicrobial peptides (LL-37 and alpha-defensins HNP1–3), antimicrobial and IgA responses to prolonged exercise

Activation pattern of neutrophils from blood of elderly individuals with Candida-related denture stomatitis

Contact Info

Product

Resources

About