Phagocytosis by human monocytes is required for the secretion of presepsin

Arai, Yasuyuki; Mizugishi, Kiyomi; Nonomura, K.; Naitoh, Katsuki; Takaori‐Kondo, Akifumi; Yamashita, Kouhei

doi:10.1016/j.jiac.2015.04.011

Cited by 88 publications

(92 citation statements)

References 29 publications

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“…Although the biological function of presepsin remains unknown, according to the data from an experimental rabbit model (21), the release mechanism is thought to be associated with phagocytosis and cleavage of microorganisms by lysosomes. Quite recently, it was reported that presepsin secretion by human monocytes is triggered by a phagocytic stimulus, and serum presepsin levels were significantly elevated in patients with HPS after allogeneic hematopoietic cell transplantation (allo-HCT) (22). A phenomenon wherein activated macrophages engulf blood cells is commonly observed in patients with HPS.…”

Section: Introductionmentioning

confidence: 99%

Plasma Levels of Presepsin (Soluble CD14-subtype) as a Novel Prognostic Marker for Hemophagocytic Syndrome in Hematological Malignancies

et al. 2016

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Objective Recent studies suggest that presepsin (soluble CD14-subtype) is a useful diagnostic and prognostic marker for sepsis, with secretion by activated macrophages potentially dependent on phagocytosis of microorganisms. As hemophagocytosis is one of the major characteristics in patients with hemophagocytic syndrome (HPS), we hypothesized that presepsin may reflect the phagocytic activity and be a useful prognostic marker for HPS. Therefore, we aimed to assess the prognostic potential of presepsin in secondary HPS in adult patients with hematological malignancies. Methods Between April 2006 and August 2014, we retrospectively examined consecutive patients with HPS whose blood samples were available at our institution and compared the prognostic value of the following in HPS, singly and in combination: plasma presepsin, serum soluble interleukin (IL)-2 receptor (sIL-2R), ferritin, tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), IL-6 and IL-10. Results A total of 14 patients were enrolled. The median age of the patients was 46.5 years (range, 22-65). In univariable Cox models, there were no significant variables associated with the prognosis. However, in 12 evaluable patients, only the combination of higher median values of presepsin (>1,935 pg/mL) and sIL-2R (>4,585 U/mL) at the onset of HPS was significantly associated with the 90-day mortality (hazard ratio 14.5; 95% CI, 1.47-143.36; p=0.02). Conclusion These results suggest that a composite model of plasma presepsin and serum sIL-2R levels at the onset of HPS might be a novel predictor of the prognosis of patients with hematological malignancies and secondary HPS.

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Section: Introductionmentioning

confidence: 99%

Plasma Levels of Presepsin (Soluble CD14-subtype) as a Novel Prognostic Marker for Hemophagocytic Syndrome in Hematological Malignancies

et al. 2016

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“…It has been shown that presepsin levels increased in a rabbit model of cecal ligation and puncture sepsis but not in a rabbit ET shock model and that presepsin production from peritoneal granulocyte was stimulated by Escherichia coli and suppressed by the inhibition of phagocytosis [7]. In vitro presepsin production by peripheral mononuclear cells was increased by Escherichia coli, Staphylococcus epidermidis, and sterile monosodium urate crystals and suppressed by an inhibitor of phagocytosis, whereas presepsin production was not induced by peptidoglycan or LPS [6]. Taking into account a report that presepsin levels were not markedly different between systemic bacterial infection patients (positive blood culture) and localized bacterial infection patients (positive culture except blood) [21], presepsin produced by bacterial phagocytosis at a localized infection site might increase the presepsin levels in circulating blood.…”

Section: Discussionmentioning

confidence: 99%

“…Although both sCD14 and presepsin are released by proteolysis with protease from monocytes, the mechanism is likely to be different. In contrast to sCD14, which was reported to be produced from cell-surface CD14 of activated monocytes [26,27], presepsin is reported to be produced from monocytes that are activated in the event of phagocytosis [6].…”

Section: Discussionmentioning

confidence: 99%

“…In contrast to conventional infection biomarkers which are induced by endotoxins or cytokines, the novel production mechanism of presepsin has been reported to be closely related to phagocytosis by monocytes [6,7]. We previously reported the usefulness of presepsin for predicting the prognosis of foot gangrene in HD patients (cut-off plasma value 2083 pg/mL) [8].…”

Section: Introductionmentioning

confidence: 99%

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Presepsin is a potent biomarker for diagnosing skin wound infection in hemodialysis patients compared to white blood cell count, high-sensitivity C-reactive protein, procalcitonin, and soluble CD14

et al. 2017

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Background: The production of presepsin has been shown to be strongly related to bacterial phagocytosis. The purpose of the present study is to compare the usefulness of presepsin for diagnosing localized skin wound infection with that of conventional infection biomarkers. Methods: We enrolled 29 hemodialysis (HD) patients with skin wound infections of foot gangrene or decubitus ("localized infection group") and 20 HD patients without infection ("no infection group"). The white blood cell (WBC) count and high-sensitivity C-reactive protein (hsCRP) and presepsin levels were measured using blood samples collected before HD, 2 days after the previous dialysis session. Soluble CD14 (sCD14) and procalcitonin (PCT) levels were also measured in 12 patients with localized infection and 8 patients without infection.

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“…In a study on human cell culture, phagocytosis was reported to stimulate presepsin release from monocytes (27). According to a study by Karti et al, reactive hemophagocytosis can develop in the course of CCHF (28).…”

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confidence: 99%

Presepsin Levels of Patients with Crimean-Congo Hemorrhagic Fever

et al. 2016

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SUMMARY: Levels of presepsin (a soluble cluster of differentiation subtype 14 [CD14]) are thought to increase in cases of bacterial infection. CD14 has also been found to play a role in the pathogenesis of various viral diseases. Crimean-Congo hemorrhagic fever (CCHF) is a zoonotic arboviral infection. Our study focuses on presepsin levels as a biomarker for CCHF. Serum presepsin levels in a CCHF group (n ＝ 59) and control group (n ＝ 28) were compared. Patients with CCHF were classified according to severity grading score as having mild, moderate, or severe infection and were allocated to corresponding subgroups (groups 1, 2, and 3, respectively). Presepsin levels were measured in serum samples by using a commercial enzyme-linked immunosorbent assay kit. The mean presepsin levels in the CCHF group as a whole and the healthy group were found to be significantly different (1,499.46 ± 411.96 pg/ml and 430.68 ± 61.21 pg/ml, respectively). The mean presepsin levels of the CCHF subgroups (1, 2 and 3) and the healthy group were also found to be significantly different (1,204.53 ± 371.18, 1,464.21 ± 338.37, 2,007.36 ± 82.18, and 430.68 ± 61.21 pg/ml, respectively) ( p ＜ 0.05). We also found that as the severity of the disease increased, the presepsin level also increased. We postulate that the presepsin levels could be used as a supportive biomarker for diagnosis and follow-up of the disease.

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Phagocytosis by human monocytes is required for the secretion of presepsin

Cited by 88 publications

References 29 publications

Plasma Levels of Presepsin (Soluble CD14-subtype) as a Novel Prognostic Marker for Hemophagocytic Syndrome in Hematological Malignancies

Plasma Levels of Presepsin (Soluble CD14-subtype) as a Novel Prognostic Marker for Hemophagocytic Syndrome in Hematological Malignancies

Presepsin is a potent biomarker for diagnosing skin wound infection in hemodialysis patients compared to white blood cell count, high-sensitivity C-reactive protein, procalcitonin, and soluble CD14

Presepsin Levels of Patients with Crimean-Congo Hemorrhagic Fever

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