Phagocytosis of bacterial pathogens

Chung, Yoon-Suk Alexander; Kocks, Christine

doi:10.4161/fly.18497

Cited by 12 publications

(4 citation statements)

References 35 publications

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“…In the present study we show that knockdown of A. gambiae draper, nimrod or eater has no effect on the transcription of the antimicrobial peptides defensin (def1), cecropin (cecA) or gambicin (gam1), which suggests that members of the Nimrod gene family do not activate the Toll or IMD pathways. This is also the case in D. melanogaster, as fruit flies lacking draper do not experience a change in their humoral response , and knockdown of eater does not affect the infection-induced transcriptional upregulation of antimicrobial peptides (Chung and Kocks, 2012). Nevertheless, although Nimrod family genes do not activate or suppress the pathways leading to antimicrobial peptide production, antimicrobial peptides may still be required for the proper function of Nimrod family genes.…”

Section: Discussionmentioning

confidence: 90%

Involvement of the Anopheles gambiae Nimrod gene family in mosquito immune responses

Estévez‐Lao

Hillyer

2014

Insect Biochemistry and Molecular Biology

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Section: Discussionmentioning

confidence: 90%

Involvement of the Anopheles gambiae Nimrod gene family in mosquito immune responses

Estévez‐Lao

Hillyer

2014

Insect Biochemistry and Molecular Biology

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“…Several plasmatocyte receptors promote the recognition and engulfment of bacteria [25]. The scavenger receptor dSR-CI and a transmembrane protein, Eater, bind to both Gram-negative and -positive bacteria [26,27].…”

Section: Introductionmentioning

confidence: 99%

The Drosophila CD36 Homologue croquemort Is Required to Maintain Immune and Gut Homeostasis during Development and Aging

et al. 2016

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Phagocytosis is an ancient mechanism central to both tissue homeostasis and immune defense. Both the identity of the receptors that mediate bacterial phagocytosis and the nature of the interactions between phagocytosis and other defense mechanisms remain elusive. Here, we report that Croquemort (Crq), a Drosophila member of the CD36 family of scavenger receptors, is required for microbial phagocytosis and efficient bacterial clearance. Flies mutant for crq are susceptible to environmental microbes during development and succumb to a variety of microbial infections as adults. Crq acts parallel to the Toll and Imd pathways to eliminate bacteria via phagocytosis. crq mutant flies exhibit enhanced and prolonged immune and cytokine induction accompanied by premature gut dysplasia and decreased lifespan. The chronic state of immune activation in crq mutant flies is further regulated by negative regulators of the Imd pathway. Altogether, our data demonstrate that Crq plays a key role in maintaining immune and organismal homeostasis.

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“…Furthermore, the interconnected roles of phagocytic activity and lysozyme activity are integral to the innate immune defense mechanism of crustaceans. The collaborative functions of these parameters contribute to the effective elimination of microbial threats (Chung and Kocks 2012). Phagocytosis, the internalization of particles or microorganisms into cells, leads to the formation of phagosomes, where degradative enzymes are released to facilitate particle elimination.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of CpG-Oligodeoxynucleotides as Immunostimulants and Protecting Agents Against Aeromonas hydrophila in Freshwater Lobster (Cherax quadricarinatus)

Tassakka,

Seniati,

Ramadhani

et al. 2024

Bulletin of the European Association of Fish Pathologists

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MAS disease (Motyle Aeromonas hydrophila) is a prevalent bacterial infection that affects freshwater lobsters. This research aimed to evaluate the potential of CpG-ODN as an immunostimulant and protecting agent in Cherax quadricarinatus lobsters. The study was conducted at the Fish Health Laboratory, Pangkep State Polytechnic, Indonesia. The lobsters were divided into different groups and injected with three types of CpG-ODN (2133, 2006, 1668) or a control group using PBS. Parameters such as Total Hemocyte Count, Phagocytic Index, and Lysozyme Activity were measured at multiple time points, including before and after injection. CpG-ODN 2006 showed significant immunostimulant effects, as evidenced by a notable increase in total hemocyte count, phagocytic index, and lysozyme activity compared to the other CpG-ODN types. On the other hand, CpG-ODN 2133 exhibited potential as a protecting agent against Aeromonas hydrophila, as lobsters injected with this CpG-ODN demonstrated higher survival rates in the challenge test compared to the control group. These findings contribute to our understanding of immunostimulant strategies and protective mechanisms in freshwater lobsters. CpG-ODN, particularly CpG-ODN 2006, shows promise as an effective immunostimulant, while CpG-ODN 2133 exhibits potential as a protecting agent against A. hydrophila. Further exploration of CpG-ODN applications could lead to advancements in disease management in aquaculture.

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Phagocytosis of bacterial pathogens

Cited by 12 publications

References 35 publications

Involvement of the Anopheles gambiae Nimrod gene family in mosquito immune responses

Involvement of the Anopheles gambiae Nimrod gene family in mosquito immune responses

The Drosophila CD36 Homologue croquemort Is Required to Maintain Immune and Gut Homeostasis during Development and Aging

Evaluation of CpG-Oligodeoxynucleotides as Immunostimulants and Protecting Agents Against Aeromonas hydrophila in Freshwater Lobster (Cherax quadricarinatus)

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