Phagostimulatory effect of uptake of PLGA microspheres loaded with rifampicin on alveolar macrophages

Endocytosis of Particle Formulations by Macrophages and Its Application to Clinical Treatment

“…Macrophage cells eat PLGA particles more efficiently than polystyrene latex ones. It is noteworthy that phagocytosis of PLGA particles by alveolar macrophage cells stimulates their phagocytic activity in such a way that their uptake increases both the population of phagocytic macrophage cells and the number of particles that have been taken up by individual macrophage [34]. However, the mechanism of interaction of PLGA with macrophage cells is still unknown.…”

“…These data are summarized from reports [34,37]. Rat alveolar macrophage cells (NR8383) were exposed to PLGA and PSL particles at a number 10 times greater than the cell number.…”

“…If efficient particle uptake is not associated with the induction of the undesirable responses, the particles could be very useful as drug carriers. As summarized in Table 1, PLGA particles are those having such a desirable silent nature regarding inflammatory responses, although they are yet well phagocytosed by macrophages compared with polystyrene latex (PSL) particles [34,37]. Namely, the PLGA particle behaves like a "Ninja," having stealth and concealment activities.…”

A novel and simple preparative method for uniform-sized PLGA microspheres: Preliminary application in antitubercular drug delivery

“…It was demonstrated by Hirota et al that the diameter of PLGA MS was a key factor that influenced the phagocytosis of the macrophages, and the most efficient delivery of antitubercular drugs into macrophages were achieved with MS at ∼3 m diameter [9]. Thereafter, most studies investigating antitubercular drug delivery with PLGA particles referred to the above optimized parameter [4,10].…”

Down-regulation of Th2 immune responses by sublingual administration of poly (lactic-co-glycolic) acid (PLGA)-encapsulated allergen in BALB/c mice

“…Phagocytosis of PLGA particles stimulated phagocytic activity resulting in an increase in both the phagocytic macrophage cell population and particles phagocytosed by individual macrophages [24]. Furthermore, encapsulated proteins were demonstrated to process and present via both MHC class I [17,25] and MHC class II [17] pathways.…”