Pharmaceutical and analytical characterisation of (2R)-(3-amino-2-fluoropropyl)sulphinic acid, a GABAB receptor agonist

Preformulation evaluation of AZD1305, an oxabispidine intended for oral and intravenous treatment

“…trace metal catalysis from the synthesis, oxygen or humidity in the air, or light exposure [5][6][7][8] . Conditions affecting the stability of the formulation include temperature, light, pH (liquids), and/ or relative humidity (RH; solid state) [9][10][11][12] . The acidic and basic nature of the molecule can be predicted from the functional groups of the compound and an initial estimation of the pK a (s) can be made before confirming analytically 13 .…”