Pharmaceutical Applications of Various Natural Gums

Deshmukh, Anand S.; Aminabhavi, Tejraj M.

doi:10.1007/978-3-319-16298-0_4

Cited by 16 publications

(6 citation statements)

References 151 publications

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“…Metal nanoparticles (Au and Ag NPs) that are covered with suitable stabilizers can provide stabilized NPs against accumulation and keep them stable in acid and alkaline environments [ 157 , 158 , 159 ]. Inorganic NPs can be stabilized by a natural gum in two ways: first, by adsorption to the surface of NPs, which causes steric repulsion between the NPs; and second, by increasing the viscosity of the suspension of NPs and, thus, slowing down the accumulation of particles [ 160 ]. It has been shown that gums with a plant basis, such as gum acacia, can be used as reductant and stabilizer agents for the biosynthesis of Ag NPs [ 161 ].…”

Section: Applicationsmentioning

confidence: 99%

Plant-Based Gums and Mucilages Applications in Pharmacology and Nanomedicine: A Review

et al. 2021

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Gums are carbohydrate biomolecules that have the potential to bind water and form gels. Gums are regularly linked with proteins and minerals in their construction. Gums have several forms, such as mucilage gums, seed gums, exudate gums, etc. Plant gums are one of the most important gums because of their bioavailability. Plant-derived gums have been used by humans since ancient times for numerous applications. The main features that make them appropriate for use in different applications are high stabilization, viscosity, adhesive property, emulsification action, and surface-active activity. In many pharmaceutical formulations, plant-based gums and mucilages are the key ingredients due to their bioavailability, widespread accessibility, non-toxicity, and reasonable prices. These compete with many polymeric materials for use as different pharmaceuticals in today’s time and have created a significant achievement from being an excipient to innovative drug carriers. In particular, scientists and pharmacy industries around the world have been drawn to uncover the secret potential of plant-based gums and mucilages through a deeper understanding of their physicochemical characteristics and the development of safety profile information. This innovative unique class of drug products, useful in advanced drug delivery applications, gene therapy, and biosynthesis, has been developed by modification of plant-based gums and mucilages. In this review, both fundamental and novel medicinal aspects of plant-based gums and mucilages, along with their capacity for pharmacology and nanomedicine, were demonstrated.

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Section: Applicationsmentioning

confidence: 99%

Plant-Based Gums and Mucilages Applications in Pharmacology and Nanomedicine: A Review

et al. 2021

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“…However, currently, pharmaceutical scientists are extensively investigating natural polymers as potential and reliable sources of release modifiers in controlled release tablets due to their myriad of advantages such as biodegradability, biocompatibility, low cost, low toxicity, and easy accessibility over synthetic and semisynthetic polymers [ 4 – 6 ]. Several studies have reported the potential of gum from different plants as promising release modifiers in the formulation of controlled release tablets [ 7 , 8 ]. However, other plant hydrocolloids such as pectin may also possess remarkable potential as release modifiers in controlled release matrix tablets.…”

Section: Introductionmentioning

confidence: 99%

Pectin from Okra (Abelmoschus esculentus L.) Has Potential as a Drug Release Modifier in Matrix Tablets

Boakye-Gyasi

Owusu

Entsie

et al. 2021

The Scientific World Journal

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Natural polymers have become attractive to pharmaceutical researchers and manufacturers as excipients because of the advantages they possess relative to their semisynthetic and synthetic counterparts. Although pectin from some natural sources has been investigated for use in the pharmaceutical industry as excipients, pectin from okra, which is readily available and used as food in many parts of the world, has not been extensively investigated as a potential control-releasing agent in tablets. This study thus seeks to determine the drug release modifying properties of okra pectin from 6 different genotypes of okra cultivated and available in Ghana. Pectin was extracted from different genotypes of okra, physicochemical properties were characterized, and control release matrix tablets of metformin (F1–F6) were formulated using the wet granulation method with the okra pectin as the drug release modifier, respectively. The drug content, in vitro drug release, and mathematical kinetic modeling of drug release from the matrix tablets were studied. Drug release profiles of formulated matrix tablets were compared to an existing (innovator) brand of metformin sustained-release tablet on the market using the similarity and difference factors, respectively. The extracted pectin had percentage yields ranging from 6 to 20% w/w with swelling indexes and water-holding capacities between 300–500% and 9-10 mL/g, respectively, and pH within 6.20–6.90. All the formulated batches passed the drug content test (90–105%) and produced the optimal release of metformin (>80%) after 24 hours. Different batches of formulated tablets exhibited different mechanisms of drug release with batches F1, F2, F5, and F6 being similar (ƒ2 values being >50 and ƒ1 values <15) to the innovator brand. Pectin from the 6 different genotypes of okra studied has the potential for use as drug release modifiers in pharmaceutical manufacturing of control release matrix tablets and production of more affordable medicines.

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“…Usually, polysaccharides can be derived from microorganisms (such as curdlan, pullulan, xanthan gum, and gellan gum), animals (such as acid mucopolysaccharide, chitin, hyaluronic acid, and chondroitin sulfate), and plants (such as konjac glucomannan, cellulose, guar gum, and carrageenan). − Among them, microorganism polysaccharides are perfect candidates from the viewpoint of high efficiency of production and simple operation of purification …”

Section: Introductionmentioning

confidence: 99%

Biocompatible Hydrogels Based on Food Gums with Tunable Physicochemical Properties as Scaffolds for Cell Culture

Zhang

et al. 2020

J. Agric. Food Chem.

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Hydrogels composed of food gums have gained attention for future biomedical applications, such as targeted delivery and tissue engineering. For their translation to clinical utilization, reliable biocompatibility, sufficient mechanical performance, and tunable structure of polysaccharide hydrogels are required aspects. In this work, we report a unique hybrid polysaccharide hydrogel composed of salecan and curdlan, in which the former is a thickening agent and the latter serves as a network matrix. The physicochemical properties, such as mechanical strength, thermal stability, swelling, and morphology, of the developed composite hydrogel can be accurately modulated by varying the polysaccharide content. Importantly, cytotoxicity assays show the non-toxicity of this hybrid hydrogel. Furthermore, this hydrogel system can support cell proliferation, migration, and function. Altogether, our work proposes a new strategy to build a polysaccharide-constructed hydrogel scaffold, which holds much promise for tissue engineering in terms of cell engraftment, survival, proliferation, and function.

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Pharmaceutical Applications of Various Natural Gums

Cited by 16 publications

References 151 publications

Plant-Based Gums and Mucilages Applications in Pharmacology and Nanomedicine: A Review

Plant-Based Gums and Mucilages Applications in Pharmacology and Nanomedicine: A Review

Pectin from Okra (Abelmoschus esculentus L.) Has Potential as a Drug Release Modifier in Matrix Tablets

Biocompatible Hydrogels Based on Food Gums with Tunable Physicochemical Properties as Scaffolds for Cell Culture

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