Pharmaceutical development of anticancer agents derived from marine sources

Nuijen, Bastiaan; Bouma, Marjan; Manada, C; Jm, Jimeno; Jh, Schellens; Bult, A.; Beijnen, J. H.

doi:10.1097/00001813-200011000-00003

Cited by 60 publications

(35 citation statements)

References 63 publications

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“…It is interesting to note that out of 18 preclinical investigating anticancer agents derived from marine sources, six are from sponges [45][46][47], implying that marine sponges are potential resources for new anti-cancer agents. However, there are just few reports in which the authors have screened Brazilian sponge extracts for biological activities [19][20][21][22].…”

Section: Ratio Pi Cells/ Total Cellsmentioning

confidence: 99%

Brazilian marine sponge Polymastia janeirensis induces apoptotic cell death in human U138MG glioma cell line, but not in a normal cell culture

et al. 2008

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Marine sponges have been prominently featured in the area of cancer research. Here, we examined the anti-proliferative effects of crude extracts (aqueous and organic) of the Brazilian marine sponge Polymastia janeirensis in the U138MG human glioma cell line. Moreover, we examined the effects of extracts on selective cytotoxicity in the glioma cells in comparison with a normal cell culture. Exposure of glioma cells to treatments (24 h) resulted in cell number decrease at all doses tested, with both aqueous and organic extracts (IC(50) <20 and <30 microg/ml, respectively). Parallel to this result, sponge extracts reduced glioma cell viability (IC(50) <15 microg/ml for both extracts). However, higher doses (50 and 100 microg/ml) induced a stronger cytotoxic effect when compared to the lower dose tested (10 microg/ml), inhibiting more than 80% of cellular growth and viability. Propidium iodide uptake and flow cytometry analysis further showed that sponge extracts caused necrosis in the glioma cell line at higher doses, while a high percentage of apoptotic glioma cells were observed at 10 microg/ml. Moreover, apoptosis was prevented by the pan-caspase inhibitor Z-VAD, suggesting that marine sponge extracts, at lower doses, induce caspase-dependent apoptosis in U138MG glioma cells. Surprisingly the extracts herein tested were more effective than temozolomide, a potent inductor of apoptosis used for the treatment of malignant gliomas. Furthermore, our results suggested a selectivity cytotoxic effect on glioma cell line in comparison with a normal cell culture, since the effect on viability found in glioma cells was not observed in astrocyte cultures with the lower dose (10 microg/ml). Thus, this marine sponge may be considered a good candidate for development of new cancer medicines with antitumor activity against gliomas.

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Section: Ratio Pi Cells/ Total Cellsmentioning

confidence: 99%

Brazilian marine sponge Polymastia janeirensis induces apoptotic cell death in human U138MG glioma cell line, but not in a normal cell culture

et al. 2008

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“…Marine invertebrates provided significant bioactive compounds including the anticancer agents psammaplins (Quiñoà and Crews, 1987;Rodriguez et al, 1987), didemnin B (Rinehart et al, 1987;Nuijen et al, 2000), dolastatin-10 (Luesch et al, 2001), ecteinascidin-743 (Rinehart et al, 1990;Wright et al, 1990) and halichondrin B (Bai et al, 1991). Currently, 62.5% (10 out of 16) of the marinederived marketed drugs or in the advanced phases of clinical trials (Phase I-Phase III) are produced by marine invertebrates, mostly sponges (Mayer et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Ehrenasterol and biemnic acid; new bioactive compounds from the Red Sea sponge Biemna ehrenbergi

Youssef

Badr

Shaala

et al. 2015

Phytochemistry Letters

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“…Indeed, through the combined efforts of chemists and pharmacologists, a number of sponge compounds are either already at advanced stages of clinical trials or have been selected as promising candidates for extended preclinical evaluation (Nuijen et al, 2000;Gonzalez, 2003).…”

Section: Resultsmentioning

confidence: 99%

Chemical and biological aspects of sponge secondary metabolites

Braekman¹,

Daloze²

2004

Phytochem Rev

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Sponge secondary metabolites have been investigated to find potential lead compounds for the development of commercially interesting products. During the Camellia project entitled 'Environmentally compatible antifouling coatings for the protection of ships, water systems, fish cages and other immersed structures against aquatic growth,' several analogues of terpenes containing isocyano, thioisocyano, thiocyano and formamide functionalities were synthesized and evaluated for their antifouling activity against the settlement of the barnacle Balanus amphitrite. The best activities were obtained with N-formylated alkylamines the length of the carbon chain of which is comprised between C-11 and C-14. In the aromatic series, the isocyano derivatives showed high antifouling activities. But they were too toxic against many microorganisms to be incorporated in paint formulations. During the Symbiosponge project entitled 'Biology of sponge natural products' the methanolic extract of about 230 sponges were submitted to bioassays guided fractionation to isolate bioactive compounds. Several cytostatic sesquiterpene quinones and tryptamine-derived alkaloids were isolated from 4 sponges of the genus Hyrtios. A new 4-sphingenine analogue and a novel polyacetylenic derivative were found to be responsible for the bioactivities of the methanolic extracts of Haliclona vansoesti and Callyspongia pseudoreticulata, respectively.

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Pharmaceutical development of anticancer agents derived from marine sources

Cited by 60 publications

References 63 publications

Brazilian marine sponge Polymastia janeirensis induces apoptotic cell death in human U138MG glioma cell line, but not in a normal cell culture

Brazilian marine sponge Polymastia janeirensis induces apoptotic cell death in human U138MG glioma cell line, but not in a normal cell culture

Ehrenasterol and biemnic acid; new bioactive compounds from the Red Sea sponge Biemna ehrenbergi

Chemical and biological aspects of sponge secondary metabolites

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