Pharmaceutical preparation of oxygen-15 labelled molecular oxygen and carbon monoxide gasses in a hospital setting

Luurtsema, Gert; Boellaard, Ronald; Greuter, Henri N.; Rijbroek, A.; Takkenkamp, K; Geest, Frank G M de; Buijs, Fred L.; Hendrikse, N. Harry; Franssen, Eric J. F.; Lingen, Arthur van; Lammertsma, Adriaan A.

doi:10.1111/j.1365-2710.2009.01032.x

Cited by 4 publications

(2 citation statements)

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“…After a transmission scan used to correct all subsequent scans for tissue attenuation, subjects underwent 3 consecutive scans, as shown in Figure 1. First, a dynamic emission scan (10 minutes, 40 frames with progressive increase in duration) was started simultaneously with injection of 1100 MBq H 2 15 13 During all scans, systemic blood pressure and peripheral saturation were registered at set intervals. Heart rate and ECG were monitored continuously.…”

Section: Data Acquisitionmentioning

confidence: 99%

Right Ventricular Failure in Idiopathic Pulmonary Arterial Hypertension Is Associated With Inefficient Myocardial Oxygen Utilization

Wong

Ruiter

Lubberink

et al. 2011

Circ: Heart Failure

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Section: Data Acquisitionmentioning

confidence: 99%

Right Ventricular Failure in Idiopathic Pulmonary Arterial Hypertension Is Associated With Inefficient Myocardial Oxygen Utilization

Wong

Ruiter

Lubberink

et al. 2011

Circ: Heart Failure

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“…The gas tracer production and gas delivery system have been described in detail elsewhere (5). After tracer production, 15 Olabeled gases were collected in an empty rubber balloon within a sealed acrylic container and allowed to decay to the prescribed dose.…”

Section: Gas Tracer Production and Administrationmentioning

confidence: 99%

Myocardial Oxygen Extraction Fraction Measured Using Bolus Inhalation of ¹⁵O-Oxygen Gas and Dynamic PET

Lubberink¹,

Wong²,

Raijmakers³

et al. 2010

J Nucl Med

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The aim of this study was to determine the accuracy of oxygen extraction fraction (OEF) measurements using a dynamic scan protocol after bolus inhalation of 15 O 2 . The method of analysis was optimized by investigating potential reuse of myocardial blood flow (MBF), perfusable tissue fraction, and blood and lung spillover factors derived from separate 15 O-water and C 15 O scans. Methods: Simulations were performed to assess the accuracy and precision of OEF for a variety of models in which different parameters from 15 O-water and C 15 O scans were reused. Reproducibility was assessed in 8 patients who underwent one 10-min dynamic scan after bolus injection of 1.1 GBq of 15 O-water, two 10-min dynamic scans after bolus inhalation of 1.4 GBq of 15 O 2 , and a 6-min static scan after bolus inhalation of 0.8 GBq of C 15 O for region-of-interest definition. Results: Simulations showed that accuracy and precision were lowest when all parameters were determined from the 15 O 2 scan. The optimal accuracy and precision of OEF were obtained when fixing MBF, perfusable tissue fraction, and blood spillover to values derived from a 15 O-water scan and estimating spillover from the pulmonary gas volume using an attenuation map. Optimal accuracy and precision were confirmed in the patient study, showing an OEF test-retest variability of 13% for the whole myocardium. Correction of spillover from pulmonary gas volume requires correction of the lung time-activity curve for pulmonary blood volume, which could equally well be obtained from a 15 O-water rather than C 15 O scan. Conclusion: Measurement of OEF is possible using bolus inhalation of 15 O 2 and a dynamic scan protocol, with optimal accuracy and precision when other relevant parameters, such as MBF, are derived from an additional 15 O-water scan. Oxygen extraction fraction (OEF) is an important parameter in describing myocardial function (1). Oxygen delivery to the healthy myocardium is regulated by varying myocardial blood flow (MBF) in response to changes in oxygen demand. In diseased myocardium, however, this relationship may be disturbed, and measurement of myocardial oxygen consumption could provide additional information, because oxygen supply to the heart may also be moderated by changes in OEF.Measurement of regional myocardial oxygen consumption has previously been described using steady-state or autoradiographic methods and applying continuous inhalation of 15 O 2 oxygen gas (1,2). Apart from the 15 O 2 scan, this protocol requires additional 15 O-water and C 15 O scans to measure MBF and blood volume, respectively. Many current low-energy proton cyclotrons, however, cannot provide a steady-state delivery of 15 O 2 to the patient. The availability of a bolus inhalation protocol would enable more widespread use of 15 O 2 gas measurements. Such a protocol has previously been described for cerebral oxygen consumption (3,4), but its use for myocardial imaging has not been described and presents several additional challenges, mainly because of increased scatter and...

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Recommendations for measurement of tumour vascularity with positron emission tomography in early phase clinical trials

et al. 2012

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Pharmaceutical preparation of oxygen-15 labelled molecular oxygen and carbon monoxide gasses in a hospital setting

Abstract: An 11 MeV proton cyclotron combined with an in-house developed gas delivery system allows for the production and administration of sufficient amounts of [(15)O]-gasses for routine clinical PET studies in an hospital setting.

Cited by 4 publications

References 10 publications

Right Ventricular Failure in Idiopathic Pulmonary Arterial Hypertension Is Associated With Inefficient Myocardial Oxygen Utilization

Right Ventricular Failure in Idiopathic Pulmonary Arterial Hypertension Is Associated With Inefficient Myocardial Oxygen Utilization

Myocardial Oxygen Extraction Fraction Measured Using Bolus Inhalation of ¹⁵O-Oxygen Gas and Dynamic PET

Recommendations for measurement of tumour vascularity with positron emission tomography in early phase clinical trials

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Pharmaceutical preparation of oxygen-15 labelled molecular oxygen and carbon monoxide gasses in a hospital setting

Abstract: An 11 MeV proton cyclotron combined with an in-house developed gas delivery system allows for the production and administration of sufficient amounts of [(15)O]-gasses for routine clinical PET studies in an hospital setting.

Cited by 4 publications

References 10 publications

Right Ventricular Failure in Idiopathic Pulmonary Arterial Hypertension Is Associated With Inefficient Myocardial Oxygen Utilization

Right Ventricular Failure in Idiopathic Pulmonary Arterial Hypertension Is Associated With Inefficient Myocardial Oxygen Utilization

Myocardial Oxygen Extraction Fraction Measured Using Bolus Inhalation of 15O-Oxygen Gas and Dynamic PET

Recommendations for measurement of tumour vascularity with positron emission tomography in early phase clinical trials

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Myocardial Oxygen Extraction Fraction Measured Using Bolus Inhalation of ¹⁵O-Oxygen Gas and Dynamic PET