“…Ciprofloxacin shows low solubility at neutral pH, leading to low bioavailability. Alternatively, the addition of carboxylic acid salts, oxalate, tartarate, benzoate, malonate, and citrate, to nofloxacin or ciprofloxacin showed higher solubility and faster dissolution at pH 6.4 in pure water and at 6.8 in phosphate buffered saline (PBS), though the opposite effect was observed at an acidic pH of 1.2 [31]. Changing the solubility of the parent compound via addition of an organic counter ion can also stabilize the parent compound, as demonstrated by the improved stability of norfloxacin, which is transformed into dihydrate at similar conditions [32].…”