Pharmaceuticals and related compounds as emerging pollutants in water: analytical aspects

Abstract

Emerging pollutants are increasingly detected in aqueous environmental samples, with
 pharmaceuticals and related compounds consisting a large category with many diverse groups,
 including parent compounds and their metabolites/transformation products. Significant research is
 performed on this subject worldwide, in order to obtain information regarding their occurrence, fate
 and health effects. In this effort, development and optimization of highly sensitive and accurate
 analytical methods for their determination in environmental samples is a necessity, but also a
 challenge. Advanced analytical methods for emerging pollutants include liquid chromatography (LC)
 or gas chromatography (GC) followed by tandem mass spectrometric (MS/MS) detection. These
 methods, combined with a variety of sample preparation procedures, provide the ability to analyze
 emerging pollutants in the environment in trace levels, and to identify and quantify their
 oxidation/degradation products. However, there are still many analytical aspects that need
 improvement and optimization for increasing the accuracy and sensitivity of the methods, in order to
 be able to fill the gaps of knowledge on the studied compounds.